Inhibitory effects of opioids on compound action potentials in frog sciatic nerves and their chemical structures

Mizuta, Kotaro; Fujita, Teizo; Nakatsuka, Terumasa; Kumamoto, Eiichi

doi:10.1016/j.lfs.2008.06.002

Cited by 40 publications

(68 citation statements)

References 47 publications

(80 reference statements)

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“…Although Yuge et al 21) mentioned that there was no signiˆcant change in the amplitude of CAPs, others reported that conduction of action potential in peripheral nerve is generally blocked by opioids. 2,22) Such an inhibition on CAP by a non-narcotic opioid tramadol, (1RS; 2RS)-2-[(dimethylamino) methyl]-1-(3-methoxyphenyl)-cylohexanol hydrochloride was also reported. 1,23) With this study, we have intended to investigate how the conduction parameters of rat nerve trunks are aŠected when the nerve is treated with diŠerent concentrations of tramadol.…”

Section: Discussionmentioning

confidence: 88%

“…Opioids are also postulated to exhibit a local anaesthetic eŠect in the peripheral nervous system. 1,2) Compound action potentials (CAPs) recorded from nerve trunk contains information concerning the number of activeˆbers and the propagation velocities of their action potentials. For the functional investigation of nerves in situ, the CAP has widespread application in basic research and in clinics; such as to determine the functional state of that particular nerve, diagnose any nervous disease, observe the nerve's growth, or deduce the conduction velocity distribution.…”

Section: Introductionmentioning

confidence: 99%

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The Effect of Tramadol on the Rat Sciatic Nerve Conduction: A Numerical Analysis and Conduction Velocity Distribution Study

Dalkılıç¹,

Tuncer²,

Barışkaner³

et al. 2009

YAKUGAKU ZASSHI

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The aim of this study was to document the eŠect of tramadol as an opioid on individualˆbers of rat sciatic nerve. To accomplish this objective, compound action potentials (CAPs) were recorded from isolated nerves treated with tramadol fromˆve diŠerent concentration levels. Then recorded CAPs and the control group were analyzed by numerical methods namely Conduction Velocity Distribution (CVD) and Fast Fourier Transform (FFT). The results show that the area under CAP and the time derivative of CAP curves decreases, and the excitability of the nerve trunk falls as well (rheobase and chronaxie increases) with increasing tramadol concentration. CVD deduced by model study was divided into subgroups as SLOW (8 26 m/s), MODERATE (26 44 m/s), MEDIUM (44 60 m/s) and FAST (60 78 m /s). The decrement in percentage relative contribution of these conduction velocity groups starts with a concentration of 0.25 mM tramadol, especially in the subgroup named FAST. The power spectrum shifts from higher frequency region to lower frequency region as the tramadol concentration increases. Theseˆndings show that fast conductingˆbers are more susceptible to tramadol than medium and moderate groups and tramadol possibly acts on channel activity rather than passive properties (such as space and time constant) of nerveˆbers.

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Section: Discussionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 99%

The Effect of Tramadol on the Rat Sciatic Nerve Conduction: A Numerical Analysis and Conduction Velocity Distribution Study

Dalkılıç¹,

Tuncer²,

Barışkaner³

et al. 2009

YAKUGAKU ZASSHI

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show abstract

“…This is an important factor for the nervous system. 26 In contrast, COD is considered very potent, unlike TRAM, which has no monoaminergic interference, and which could have great beneficial action, instead of being just another opioid. 19 It is known that codeine opioid molecularity is considered different in the opioid group, since it promotes greater concentration of effects on ionic membrane mechanisms and less dependency.…”

Section: Discussionmentioning

confidence: 99%

“…19 It is known that codeine opioid molecularity is considered different in the opioid group, since it promotes greater concentration of effects on ionic membrane mechanisms and less dependency. Thus, activity in K + , Ca 2+ and even Na + channels is possible, 26,23,22 thus implying a reduction in or blockage of potential cellular hyperpolarization. 22 The influx of Ca 2+ and induction of K + in the nerve terminal is considered the trigger for release in synaptic cleft neurotransmitters.…”

Section: Discussionmentioning

confidence: 99%

Effects of opioids on local anesthesia in the rat: a codeine and tramadol study

et al. 2013

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Opioids are central analgesics that act on the CNS (central nervous system) and PNS (peripheral nervous system). We investigated the effects of codeine (COD) and tramadol (TRAM) on local anesthesia of the sciatic nerve. Eighty Wistar male rats received the following SC injections in the popliteal fossa: local anesthetic with epinephrine (LA); local anesthetic without vasoconstrictor (LA WV); COD; TRAM; LA + COD; LA + TRAM; COD 20 minutes prior to LA (COD 20' + LA) or TRAM 20 minutes prior to LA (TRAM 20' + LA). As a nociceptive function, the blockade was considered the absence of a paw withdraw reflex. As a motor function, it was the absence of claudication. As a proprioceptive function, it was the absence of hopping and tactile responses. All data were compared using repeated-measures analysis of variance (ANOVA). Opioids showed a significant increase in the level of anesthesia, and the blockade duration of LA + COD was greater than that of the remaining groups (p < 0.05). The associated use of opioids improved anesthesia efficacy. This could lead to a new perspective in controlling dental pain.

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“…Aplicação direta de tramadol sobre o nervo ciático reduz de modo relacionado à dose tanto a amplitude, quanto a velocidade de condução de potenciais evocados somatosensoriais na medula espinhal de ratos (Tsai et al, 2001). Diversos opióides como morfina, codeína, etilmorfina e dihidrocodeína reduzem a amplitude de potenciais de ação de nervos isolados, sendo a potência individual de cada substância em produzir este efeito, independente de sua afinidade por receptores opióides (Mizuta et al, 2008).…”

Section: Ação Do Tramadol Na Condução Neuralunclassified

Efeito analgésico periférico do tramadol em ratos

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Inhibitory effects of opioids on compound action potentials in frog sciatic nerves and their chemical structures

Cited by 40 publications

References 47 publications

The Effect of Tramadol on the Rat Sciatic Nerve Conduction: A Numerical Analysis and Conduction Velocity Distribution Study

The Effect of Tramadol on the Rat Sciatic Nerve Conduction: A Numerical Analysis and Conduction Velocity Distribution Study

Effects of opioids on local anesthesia in the rat: a codeine and tramadol study

Efeito analgésico periférico do tramadol em ratos

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