Local and Systemic Oxidative Stress and Glucocorticoid Receptor Levels in Chronic Obstructive Pulmonary Disease Patients

Abstract

Oxidative stress levels were elevated in COPD patients. There was a correlation between local and systemic oxidative status in COPD, and between decreased SOD activity and decreased GR levels in COPD patients.

The Role of Oxidative Stress in Severity of Obstructive Pulmonary Complications in Sputum of Sulfur Mustard-Injured Patients

“…The mRNA expressions of Mn-SOD and Cu Zn-SOD were significantly increased in the lungs of SM-exposed patients [27]. SOD, CAT and GST activities may be increased or decreased in various pulmonary diseases including asthma and COPD [6,11,17,25]. Jafari and Ghanei reported a significant increase in SOD and CAT activities in plasma, erythrocytes, and brochoalveolar lavage fluid (BAL) and GST activity in BAL of patients with SM-induced lung injuries [8].…”

“…Both total and oxidized GSH are increased in the sputum of patients with moderate to-severe COPD [19]. By contrast, SOD, GSH, and glutathione peroxidase (GPx) levels in the sputum were lower as compared with the healthy smoker and nonsmoker subjects [6].…”

“…Spirometer) were classified based upon forced expiratory volume in 1 second (FEV1) values as mild (FEV1 60-80% predicted), moderate (40-59% predicted) and severe (less than 40% predicted) disease [6].…”

“…Reactive oxygen species (ROS) are involved in the pathogenesis and progression of many lung diseases such as asthma and chronic obstructive pulmonary disease (COPD) [6,7]. SM-induced pulmonary disease is associated with inflammation and neutrophil excess [8].…”

“…This method is frequently used to show oxidative stress in many studies concerning pulmonary diseases [6,17].…”