Infection-Induced Oxidative Stress in Chronic Respiratory Diseases

Shukla, Shakti D.; Vanka, Kanth Swaroop; Chevalier, Anne; Chong, Wai Ching; Pabreja, Kavita; Shastri, Madhur D.; O’Toole, Ronan

doi:10.1007/978-981-15-1568-2_8

Cited by 4 publications

(3 citation statements)

References 134 publications

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“…It is known that age is a risk factor proportional for respiratory diseases, i.e., the younger/older, the greater the risk for the development of these diseases. 1 Risk factors for hospitalization for respiratory diseases include: exposure to environmental pollutants, especially smoking; household agglomeration; deficit in nutritional status; climatic seasonality; incomplete immunization schedules; low socioeconomic status; and exposure to biological agents, such as pollen. Such factors mainly affect individuals at the extremes of age, such as children under 5 years old and older adults over 65 years old.…”

Section: Introductionmentioning

confidence: 99%

“…Such factors mainly affect individuals at the extremes of age, such as children under 5 years old and older adults over 65 years old. 1 Groups that are susceptible to respiratory diseases in children are highly susceptible to exposure to air pollutants. They have greater minute ventilation due to accelerated basal metabolism and greater physical activity when compared to adults, in addition to staying longer in outdoor environments.…”

Section: Introductionmentioning

confidence: 99%

“…There is a reduction in chest wall compliance and pulmonary hyperinflation, causing additional energy expenditure to perform respiratory movements, in addition to a functional decrease in organic systems. 1 Several studies involving adjustment of estimates using probabilistic/theoretical models in relation to historical data series have been developed, highlighting the benefits in planning activities that minimize risks, among which precipitation, air temperature, solar radiation, concentration of polluting gases historical seires stand out. However, there is published work (according to the authors' best knowledge) on historical series of hospitalizations for respiratory diseases based on the methodology used in this research, developed by Sousa STATISTICAL MODELING OF HOSPITAL ADMISSIONS FOR PNEUMONIA IN CAMPO GRANDE Amaury de Souza, Debora Aparecida Silva Santos, Marcel Carvalho Abreu, José Francisco de Oliveira-Júnior, Pedro Luiz Ramos, Francisco Louzada, Elania Barros da Silva, Pobocikova Ivana.…”

Section: Introductionmentioning

confidence: 99%

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Statistical modeling of hospital admissions for pneumonia in Campo Grande

Souza

Abreu

Júnior

et al. 2021

Rev Epidemiol Control Infect

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Justification and Objectives: Brazil lacks consistent epidemiological data on the respiratory morbidity of children and older adults, which makes it difficult to plan and execute effective preventive and health promotion actions. The objective of this study was to analyze the adjustments of distributions (Weibull, Normal, Gamma, Logistic) of historical series of hospitalizations for respiratory diseases (total hospitalizations), from 2011 to 2015, in Campo Grande, Mato Grosso do Sul. Methods: to determine the statistical models, four statistical indicators (coefficient of determination, mean root square error, mean absolute error and mean absolute percentage error) were performed from 2011 to 2015. Parameter estimates are obtained for the models adopted in the study, with and without a regression structure. Results: the results showed that Weibull, Gamma, Normal and Logistic distributions, applied to the series of hospitalizations for respiratory diseases in Campo Grande, were satisfactory in determining the shape and scale parameters, and the statistical indicators R2, MAE, RSME and MAPE confirmed the data goodness-of-fit, and the graphical analysis indicated a satisfactory distribution fit. Conclusion: the analysis of monthly values indicates that Gamma is the best of the four distributions based on those selected. The regression model can be adjusted to the data and used as an alternative distribution that describes the hospitalization data considered in Campo Grande, Brazil.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Statistical modeling of hospital admissions for pneumonia in Campo Grande

Souza

Abreu

Júnior

et al. 2021

Rev Epidemiol Control Infect

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Influence of chitotriosidase gene polymorphisms on oxidative stress and susceptibility to Aspergillus infection among exposed workers

Moubarz

Shousha

Saad-Hussein

et al. 2022

International Journal of Environmental Health Research

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Antioxidants as adjuvant therapy in the treatment of community-acquired pneumonia

Youssef,

Elmokadem,

Samy

et al. 2024

Futur J Pharm Sci

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Background Community-acquired pneumonia remains a major health concern, characterized by significant morbidity and mortality. The underlying pathophysiology of community-acquired pneumonia involves substantial oxidative stress and inflammation, which contribute to lung tissue damage and impaired immune function. Main body Variations in oxidative metabolism contribute to the inflammatory cascade which triggers pneumonia to commence and evolve, whereas oxidative stress as well as inflammatory processes is strongly related. Understanding the underlying immunological dysregulation and unbalanced redox that heighten vulnerability to a variety of illnesses has improved over the past several decades attributable to research. One of the key strategies for addressing oxidative stress is to lower the reactive oxygen species creation in the mitochondrion which is one of the main sites of their generation by using antioxidants, where they prevent oxidants from transferring electrons to other molecules. Consequently, antioxidants either directly or indirectly reduce the risk of damage and preserve the redox equilibrium. Therefore, antioxidants, due to their ability to neutralize reactive oxygen species and modulate inflammatory processes, have been explored as potential adjuvant therapies to enhance the treatment outcomes of community-acquired pneumonia. Where recent research has explored the potential of antioxidants as adjuvant therapy in the treatment of community-acquired pneumonia, aiming to mitigate these detrimental effects. Antioxidants such as N-acetylcystein, vitamin C, vitamin E, astaxanthin, and zinc have shown promising results in both preclinical and clinical studies. Conclusion Outcomes of several in vitro as well as in vivo antioxidant studies have demonstrated the antioxidants' promising potential as an adjunct pneumonia therapy. For an assessment of its effectiveness in this therapeutic context, more research involving humans will be required.

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Infection-Induced Oxidative Stress in Chronic Respiratory Diseases

Cited by 4 publications

References 134 publications

Statistical modeling of hospital admissions for pneumonia in Campo Grande

Statistical modeling of hospital admissions for pneumonia in Campo Grande

Influence of chitotriosidase gene polymorphisms on oxidative stress and susceptibility to Aspergillus infection among exposed workers

Antioxidants as adjuvant therapy in the treatment of community-acquired pneumonia

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