Local and Systemic Immunity Research of Herpetic and Chlamydial-Herpetic Infection

Abstract

Investigation of the immune status and TNF-α, IFNγ and IL-10 concentration in the ejaculate and venous blood serum of 100 men with STI (marked as main group (MG)) has been conducted. MG men were divided into 2 subgroups: 50 men with chronic viral urethritis (genital herpes-herpetic urethritis (HU)) and 50 patients with с viral-bacterial urethritis (genital herpes, associated with chlamydiosis-herpetic-chlamydial urethritis (HCU)). Comparative group (control group) were included 20 apparently healthy male-volunteers. More perceptible disfunctions of the local and systemic immunity have been revealed in patients with viral-bacterial urethritis: elevating of CD3+ CD25+ expression as well as indicators of late negative activation markers have been recorded on the background of phagocytosis indicators reducing, reliable rising of TNFα level in the venous blood serum have been marked, similar cytokine level in the ejaculate has been considerably higher as compared with the herpetic urethritis group and controls; also IFNγ/IL-10 ratio lowering has been noted either in the venous blood serum, or in the seminal fluid compared with the control group.