Local and systemic cytokine responses during larval penetration in cattle experimentally infested with Hypoderma lineatum (Diptera: Oestridae)

Dacal, V.; Colwell, Douglas D.; López, C.; Pérez, Valentín Pérez; Vázquez, Luis; Cienfuegos, Sandra Patricia de la Garza; Díaz, Pablo; Morrondo, P.; Díez‐Baños, P.; Fontán, Rosario Panadero

doi:10.1016/j.vetimm.2009.03.011

Cited by 15 publications

(11 citation statements)

References 22 publications

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“…Recently, Dacal et al (2009) studied the Local and systemic cytokine responses in three groups of cattle, experimentally infested with H. lineatum first instars (L1). The increase of both Th1 (IFN-gamma) and Th2-type cytokines (IL-4 and IL-10) indicated that bovine T-cell response during the first phases of the infestation by H. lineatum is apparently a Th0 response.…”

Section: Biologymentioning

confidence: 99%

Bovine hypodermosis—a global aspect

Hassan

Khan

Abubakar³

et al. 2010

Trop Anim Health Prod

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Cattle hypodermosis (warble fly infestation) is a notorious veterinary problem throughout the world. Larvae of Hypoderma species cause a subcutaneous myiasis of domesticated and wild ruminants. This disease is caused by, Hypoderma bovis, Hypoderma lineatum in cattle whereas, Hypoderma diana, Hypoderma actaeon, and Hypoderma tarandi, affect roe deer, red deer, and reindeer, respectively. Adults of the cattle grub are commonly known as heel flies, warble flies, bomb flies or gad flies. The biology of hypodermosis is complex because it passes through ecto- as well as endoparasitic stages in the life cycle. The parasitic stage of hypodermosis lasts about 1 year in domesticated as well as in the wild animals, while in the adult stage, a free-living fly lasts only for few days. The diagnosis of hypodermosis is of prime importance for planning treatment and the eradication program. Generally, there are two methods that are routinely used for diagnosis of hypodermosis, i.e., the direct clinical examination and immuno diagnosis by the use of pooled serum and/or milk sample. For the control of hypodermosis, different preparations are available and their use in most of the countries is limited to an individual level but never cover the whole cattle population of a country. Re-infestation in the herd occurs due to the untreated animals that remain the reservoir of the disease. The disease causes huge economic losses in animal production due to the effect of this disease on meat, milk, and the leather industry. It can also affect the general health status as well as the immune system of the body of the diseased animals. As regards the control measures of the disease, different methods have been efficiently practiced and consequently this disease is controlled at national level in many European countries.

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Section: Biologymentioning

confidence: 99%

Bovine hypodermosis—a global aspect

Hassan

Khan

Abubakar³

et al. 2010

Trop Anim Health Prod

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“…While lesions caused by first instar larvae during penetration and migration in the host are well described (López et al, 2005;Dacal et al, 2009Dacal et al, , 2011, not detailed descriptions on the different pathological responses associated with the presence of the larvae in the subcutaneous tissue have been carried out. Moreover, little information is also available on the cellular reactions responsible for larval isolation or destruction at sub-dermal sites.…”

Section: Introductionmentioning

confidence: 99%

Histological and immunohistochemical characterization of Hypoderma lineatum (Diptera: oestridae) warbles

Cabanelas

Fontán

Fuertes

et al. 2015

Veterinary Parasitology

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“…HA binds with cells and certain types of proteins or receptors that stabilize the integrity of ECM (Laurent and Fraser 1992). Thus, depolymerization of HA is known as an indicator for tissue damage and initiation of inflammatory responses (Chen and Abatangelo 1999) which are well associated with penetration activity (Dacal et al 2009). …”

Section: Introductionmentioning

confidence: 99%

Urinary hyaluronidase activity in rats infected with Blastocystis hominis—evidence for invasion?

et al. 2010

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The fact whether Blastocystis hominis can invade has always been in question. Apart from a few sporadic studies such as that done on gnotobiotic guinea pigs which showed surface invasion and mucosal inflammation of the host's intestine caused by B. hominis infection, no real documentation of invasion has been proven. Studies have shown that hyaluronidase is secreted during the penetration into the host's skin and gut by nematode parasites. Hyaluronidase activity in protozoa namely Entamoeba histolytica has also been described previously. This study attempts to determine hyaluronidase in urine samples of B. hominis-infected rats. The presence of hyaluronidase in urine provides an indirect evidence of invasion by B. hominis into colonic epithelium causing the degradation of extracellular matrix proteins namely hyaluronic acid (HA). HA is depolymerized by hyaluronidase which may be used by organisms to invade one another. In this study, the levels of urinary hyaluronidase of Sprague-Dawley rats infected with B. hominis were monitored for 30 days. Hyaluronidase levels in the infected rats were significantly higher on days 28 and 30 compared to the day before inoculation (P < 0.01 and P < 0.05, respectively). During this stage, parasitic burden in infected stools was also at a high level. Proinflammatory cytokines, interleukin-6 and interleukin-8, were also significantly higher (P < 0.05) in the serum of infected rats. The study demonstrates that since no other pathogen was present and that amoeboid forms of the parasites have been shown to exist previously, the elevated levels of hyaluronidase in this preliminary finding suggests that the organism is capable of having invasion or penetration activity in the hosts' intestine.

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Local and systemic cytokine responses during larval penetration in cattle experimentally infested with Hypoderma lineatum (Diptera: Oestridae)

Cited by 15 publications

References 22 publications

Bovine hypodermosis—a global aspect

Bovine hypodermosis—a global aspect

Histological and immunohistochemical characterization of Hypoderma lineatum (Diptera: oestridae) warbles

Urinary hyaluronidase activity in rats infected with Blastocystis hominis—evidence for invasion?

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