Local and systemic adverse effects of imiquimod therapy for external anogenital warts in men: report of three cases

Rosenblatt, Alberto; Guidi, Homero Gustavo de Campos

doi:10.1258/ijsa.2012.012076

Cited by 18 publications

(12 citation statements)

References 7 publications

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“…Therefore, TNF-α expression in SCC and BCC cell lines was determined and concentration-dependent response was plotted for the IMQ, IMQ-FO, and omega-3 fatty acids. Imiquimod is known for its inflammatory side effects 3,4 , and during the study IMQ concentrations appeared to increase the TNF-α expression in both carcinoma cell lines Fig. 5 .…”

Section: Tumor Necrosis Factormentioning

confidence: 87%

“…Imiquimod is an immune response modifier 1 and has been widely prescribed by dermatologists as a topical treatment, especially for curing skin conditions such as actinic keratosis, skin warts, and carcinoma 2 . Conversely, it is also known for its inflammatory-like side effects, such as severe skin inflammation 3,4 . In our earlier work, we demonstrated an interaction between fish oil and imiquimod 5 to explain observations seen in the delivery of imiquimod from fish oil-based gel system.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Immunomodulatory Effectiveness of Fish Oil and omega-3 Fatty Acids in Human Non-melanoma Skin Carcinoma Cells

et al. 2016

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Section: Tumor Necrosis Factormentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Immunomodulatory Effectiveness of Fish Oil and omega-3 Fatty Acids in Human Non-melanoma Skin Carcinoma Cells

et al. 2016

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“…In randomized trials, the most common side effect of imiquimod is local erythema, which has been reported in up to 42% of patients [35] . Otherwise, it is well tolerated but occasionally can lead to more pronounced unwanted effects such as adenopathy [36] , severe eczema [37] , vitiligo [38] or meningitis [39] . In women with EPDV, imiquimod was generally well tolerated with mild-to-moderate local reactions in a majority of cases.…”

Section: Discussionmentioning

confidence: 99%

Paget's Disease of the Vulva Treated with Imiquimod: Case Report and Systematic Review of the Literature

Doğan

Hilal

Krentel

et al. 2016

Gynecol Obstet Invest

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Background: Extramammary Paget's disease of the vulva (EPDV) is a rare adenocarcinoma in situ of the vulvar skin and is often resected with involved margins due to its reticular growth pattern. Adjuvant treatment with the immunomodulator imiquimod may be suitable to avoid repeated and mutilating surgery. Case Presentation: We present the case of a 73-year-old woman with EPDV, initially treated with surgical resection and re-resection for involved margins. Final histology revealed Paget's disease of the left vulva with 8 cm in the largest diameter and again involved margins. Subsequently, topical therapy with imiquimod 5% cream twice weekly was applied for 3 months. Vulvoscopy and local biopsies confirmed complete remission (CR). Based on a literature search using PubMed and the Cochrane Central Register of Controlled Trials, 21 reports on the therapeutic efficacy of imiquimod in 70 women with EPDV have been published. Pooled rates of CR and partial remission were 71% (50/70) and 16% (11/70), respectively. There were 4 cases of disease progression under imiquimod and the therapy was generally well tolerated with mild to moderate local reactions in >50% of cases. Conclusion: EPDV is a rare genital neoplasia and may be successfully treated with the topical immunomodulator imiquimod. Specifically, adjuvant imiquimod is a feasible and efficacious treatment option for women with involved resection margins after surgery.

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“…These inflammatory effects typically subside within 2 weeks of treatment discontinuation. Rare side effects include: psoriasiform eruptions and oral ulcers [11], and a meningitis-like effect that resolved upon cessation of treatment [12]. Also, because imiquimod is expensive, it may not be a feasible option for patients with certain insurance plans.…”

Section: Imiquimodmentioning

confidence: 99%

Management of Cutaneous Human Papillomavirus Infection: Pharmacotherapies

Ramírez-Fort

Au²,

Javed³

et al. 2014

Human Papillomavirus

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A plethora of different treatment modalities for treating human papillomavirus (HPV) are available, offering a range of efficacies and balancing several patient needs. Here we discuss pharmacotherapies for HPV, focusing in particular on the mechanism of action and treatment efficacy. Immunomodulators such as Candida antigen, imiquimod and squaric acid stimulate cell-mediated immunity and induce production of antiviral cytokines. Proapoptotic and antiviral treatments such as podophyllin resin, podophyllotoxin gel, bleomycin, 5-fluorouracil, cidofovir and interferon α interfere with the viral reproduction cycle. Other therapies include trichloroacetic acid, acitretin, cantharidin and sinecatechins, some of which operate by epidermal destruction, effects on cellular proliferation and other mechanisms of which are poorly understood. Overall, given the high HPV recurrence rates, adjunctive use of antiviral agents should be considered in treatment, especially when managing severe or complicated presentations.

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Local and systemic adverse effects of imiquimod therapy for external anogenital warts in men: report of three cases

Cited by 18 publications

References 7 publications

Immunomodulatory Effectiveness of Fish Oil and omega-3 Fatty Acids in Human Non-melanoma Skin Carcinoma Cells

Immunomodulatory Effectiveness of Fish Oil and omega-3 Fatty Acids in Human Non-melanoma Skin Carcinoma Cells

Paget's Disease of the Vulva Treated with Imiquimod: Case Report and Systematic Review of the Literature

Management of Cutaneous Human Papillomavirus Infection: Pharmacotherapies

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