Immunomodulatory Effectiveness of Fish Oil and omega-3 Fatty Acids in Human Non-melanoma Skin Carcinoma Cells

Rehman, Khurram; Amin, Mohd Cairul Iqbal Mohd; Yuen, Ng Pei; Zulfakar, Mohd Hanif

doi:10.5650/jos.ess15256

Cited by 15 publications

(8 citation statements)

References 24 publications

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“…Nevertheless, it is known to cause severe skin inflammation. Based on the concept of synergistic carcinoma inhibition for lowering the administered dose, fish oil was used in combination with imiquimod to treat human basal (BCC) and squamous carcinoma cells (SCC) [70]. The fish oil utilized in this case was composed of 21% DHA and 42% EPA.…”

Section: Fatty Acids For Skin Disorder Prevention and Treatmentmentioning

confidence: 99%

Cosmetic and Therapeutic Applications of Fish Oil’s Fatty Acids on the Skin

et al. 2018

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Fish oil has been broadly reported as a potential supplement to ameliorate the severity of some skin disorders such as photoaging, skin cancer, allergy, dermatitis, cutaneous wounds, and melanogenesis. There has been increasing interest in the relationship of fish oil with skin protection and homeostasis, especially with respect to the omega-3 polyunsaturated fatty acids (PUFAs), docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA). The other PUFAs, such as α-linolenic acid (ALA) and linoleic acid (LA), also show a beneficial effect on the skin. The major mechanisms of PUFAs for attenuating cutaneous inflammation are the competition with the inflammatory arachidonic acid and the inhibition of proinflammatory eicosanoid production. On the other hand, PUFAs in fish oil can be the regulators that affect the synthesis and activity of cytokines for promoting wound healing. A systemic review was conducted to demonstrate the association between fish oil supplementation and the benefits to the skin. The following describes the different cosmetic and therapeutic approaches using fatty acids derived from fish oil, especially ALA, LA, DHA, and EPA. This review summarizes the cutaneous application of fish oil and the related fatty acids in the cell-based, animal-based, and clinical models. The research data relating to fish oil treatment of skin disorders suggest a way forward for generating advances in cosmetic and dermatological uses.

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Section: Fatty Acids For Skin Disorder Prevention and Treatmentmentioning

confidence: 99%

Cosmetic and Therapeutic Applications of Fish Oil’s Fatty Acids on the Skin

et al. 2018

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“…The diet with ω-3 PUFAs reduced hepatic lipid accumulation and tumor growth and induced an increase in the number of macrophages with a simultaneous decrease in TNF-α expression in liver tissues (Liebig et al, 2019). The immunomodulatory properties of ω-3 PUFAs in fish oil capable of attenuating the proinflammatory side effects of the anticancer drug imiquimod in human nonmelanoma skin carcinoma cells were reported by Rehman et al Indeed, ω-3 PUFAs increased the expression of IL-10 and suppressed the expression of IL-6 and TNF-α (Rehman et al, 2016). ω-3 PUFAs can also be useful for the treatment of rheumatoid arthritis; they were found to attenuate arthritis in an anticollagen antibody-induced arthritis mouse model by increasing the number and differentiation of Tregs and reducing IL-17, IL-6 and IL-23 production in the spleen and joint tissues (J. Y.…”

Section: Fatty Acidsmentioning

confidence: 80%

Targeting the tumor immune microenvironment with “nutraceuticals”: From bench to clinical trials

Masuelli

Benvenuto

Focaccetti

et al. 2021

Pharmacology & Therapeutics

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“…In relation to the context of IL-6 and melanoma cancer, while increased expression of this cytokine in the melanoma microenvironment has been shown to favor the occurrence of tumor cachexia [28] and metastasis [29,30], it was reported that omega-3 and its metabolites can decrease tumor growth of both human non-melanoma skin carcinoma cells [31] and melanoma cells [32] through the reduction of pro-inflammatory cytokines levels, such as IL-6, in the tumor microenvironment. However, we did not observe alterations in the IL-6 levels of both in vitro and in vivo treatment with the fatty acids omega-3 or omega-6.…”

Section: Discussionmentioning

confidence: 99%

“…In this context, Tuccitto et al [34] mentioned that, due to the extreme heterogeneity of the melanoma microenvironment, it is possible that the actions of IL-10 in this microenvironment may be subjected to the influence of other substances and may alter the plasticity modeling of the melanoma. Interestingly, it was demonstrated that omega-3 can increase IL-10 levels in skin cancer and its elevation was able to inhibit the pro-inflammatory cytokines production, leading to reduced tumor growth and progression [31,35]. Based on these observations, we analyzed the ratio between the levels of IL-10 and the other cytokines (IL-6 and CXCL1) in the melanoma microenvironment.…”

Section: Discussionmentioning

confidence: 99%

A Mixture of Polyunsaturated Fatty Acids ω-3 and ω-6 Reduces Melanoma Growth by Inhibiting Inflammatory Mediators in the Murine Tumor Microenvironment

Almeida

Silva

Paixão

et al. 2019

IJMS

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Background: Although it has been previously demonstrated that acute inflammation can promote the tumor growth of a sub-tumorigenic dose of melanoma cells through of 5-lipoxygenase inflammatory pathway and its product leukotriene B4, and also that the peritumoral treatment with eicosapentaenoic acid and its product, leukotriene B5, reduces the tumor development, the effect of the treatment by gavage with omega-3 and omega-6 in the tumor microenvironment favorable to melanoma growth associated with acute inflammation has never been studied. Methods: C57BL/6 mice were coinjected with 1 × 106 apoptotic cells plus 1 × 103 viable melanoma cells into the subcutaneous tissue and treated by gavage with omega-3-rich fish oil or omega-6-rich soybean oil or a mixture of these oils (1:1 ratio) during five consecutive days. Results: The treatment by gavage with a mixture of fish and soybean oils (1:1 ratio) both reduced the melanoma growth and the levels of leukotriene B4 (LTB4), prostaglandin E2 (PGE2), PGE2/prostaglandin E3 (PGE3) ratio, and CXC ligand 1 (CXCL1) and increased the levels of interleukin 10 (IL-10) to IL-10/CXCL1 ratio in the melanoma microenvironment. Conclusion: The oral administration of a 1:1 mixture of fish oil and soybean oil was able to alter the release of inflammatory mediators that are essential for a microenvironment favorable to the melanoma growth in mice, whereas fish oil or soybean oil alone was ineffective.

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Immunomodulatory Effectiveness of Fish Oil and omega-3 Fatty Acids in Human Non-melanoma Skin Carcinoma Cells

Cited by 15 publications

References 24 publications

Cosmetic and Therapeutic Applications of Fish Oil’s Fatty Acids on the Skin

Cosmetic and Therapeutic Applications of Fish Oil’s Fatty Acids on the Skin

Targeting the tumor immune microenvironment with “nutraceuticals”: From bench to clinical trials

A Mixture of Polyunsaturated Fatty Acids ω-3 and ω-6 Reduces Melanoma Growth by Inhibiting Inflammatory Mediators in the Murine Tumor Microenvironment

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