Local and Systemic Administration of Corticosteroids in the Treatment of Olfactory Loss

Heilmann, Stefan; Huettenbrink, Karl‐Bernd; Hummel, Thomas

doi:10.1177/194589240401800107

Cited by 138 publications

(140 citation statements)

References 33 publications

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“…The fact that corticosteroid pressure-pulsed inhalation is more effective than corticosteroid nasal spray [14] may be due to the manner of application. Due to the pressure with which the corticosteroid is applied obstructive lesions in the nasal cavity may be overcome; similar to the headdown-forward position [24].…”

Section: Discussionmentioning

confidence: 99%

Treatment of Chronic Rhinosinusitis with Pressure-Pulsed Corticosteroid Inhalation

Goektas¹,

Lau²

2013

Indian J Otolaryngol Head Neck Surg

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Chronic rhinosinusitis may cause olfactory dysfunction and affects quality of life in patients. In a prospective study we investigated the effect of topical application of corticosteroids through pressure-pulsed inhalation as treatment option of chronic rhinosinusitis with olfactory disorder. Patients with sinonasal olfactory disorder according to the European Position Paper on Rhinosinusitis and Nasal Polyps (EP3OS) were allocated to the new nasal inhalation therapy or a systemic corticosteroid therapy, each receiving a corticosteroid course of 12 days. 18 patients received topical corticosteroid pressure-pulsed inhalation (AMSA, Schumacher, Dausenau) and 15 systemic corticosteroid. Olfactory function was measured before and after treatment using the Threshold Discrimination Identification score (TDI score) and visual analogue scales. Lund Mackay score (LMS) was measured before starting treatment. Olfactory function (OF) increased from 17.5 ± 6.4 to 21 ± 7.9 TDI points (p \ 0.0005) after 2 months. OF decreased again to 19.5 ± 6.0 after 6 months (p = 0.007). OF increased from 17.0 ± 8.9 to 22.0 ± 9.5 points (p = 0.002) with systemic treatment after 2 months. In the follow-up period of 6 months, the mean TDI score dropped to 20.0 ± 9.2 points (p = 0.01). There was no correlation between LMS and TDI. Treatment of chronic rhinosinusitis with pressure-pulsed inhalation was demonstrated to be effective. Multicenter investigations with large participant numbers are needed.

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Section: Discussionmentioning

confidence: 99%

Treatment of Chronic Rhinosinusitis with Pressure-Pulsed Corticosteroid Inhalation

Goektas¹,

Lau²

2013

Indian J Otolaryngol Head Neck Surg

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“…However, few patients benefit from intranasal drug application. 5,6,14 The reason for this therapeutic failure may partly be due to the spray not reaching the olfactory epithelium. The olfactory mucosa is found only in an area at the top of the nasal cavity on both sides, where it reaches from the insertion of the middle turbinate up to the cribriform plate, the superior turbinate, and the opposite septum.…”

Section: Arch Otolaryngol Head Neck Surg 2008;134(6):643-646mentioning

confidence: 99%

Intranasal Administration of Drugs

Scheibe¹,

Bethge²,

Witt³

et al. 2008

Arch Otolaryngol Head Neck Surg

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“…Mometasone nasal spray showed the greatest effectiveness in reducing fibroblast cultures in nasal polyps followed by beclomethasone [18]. Recent results tend to prove that patients with an olfactory dysfunction after upper respiratory tract infection, idiopathic and sinonasal olfactory dysfunction benefit from a topic application of a corticosteroid, too [19,20].…”

Section: Discussionmentioning

confidence: 99%

Effect of Laser Treatment on Olfactory Dysfunction

Göktas

Lau

Fleiner

2011

Indian J Otolaryngol Head Neck Surg

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Olfactory disorders are not rare and affect quality of life in patients. The purpose of our study was to evaluate the outcomes of an outpatient-based diode laser inferior turbinate reduction (ITR) in otherwise therapyrefractory olfactory disorder. In a prospective clinical investigation, 20 patients (7 male, 13 female, mean age 53.2 ± 15.34) with olfactory disorder and 10 patients (8 male, 2 female, mean age 52.5 ± 17.55) without olfactory disorder underwent ITR under videoendoscopic control with a continuous diode laser in ''contact'' mode after topical anesthetic preparation. Treatment efficiency was assessed before and 2 months after surgery. Subjective nasal airflow (NA) and the olfactory function were rated by means of visual analogue scales (VAS). Olfactory function was assessed using the ''Sniffin' Sticks'' test battery. VAS showed very low median values for intraoperative pain (0) [0-1.20] and high postoperative patient satisfaction (8) [5][6][7][8][9]. After 2 months there was no significant improvement of objective olfactory function as measured by the TDI score (threshold, discrimination and identification). The VAS displayed a slight significant improvement in the group of patients with olfactory disorder from 2.95 to 3.65 (P = 0.04). After 2 months, NA data revealed a statistically significant improvement of subjective VAS from 5.05 to 6.25 (P \ 0.0005) and of objective NA from 353.77 to 443.50 (P = 0.007) as measured by rhinomanometry in both groups. Outpatient diode laser ITR represents an effective option providing recovery by NA improvement but not a significant improvement of the olfactory function.

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Local and Systemic Administration of Corticosteroids in the Treatment of Olfactory Loss

Cited by 138 publications

References 33 publications

Treatment of Chronic Rhinosinusitis with Pressure-Pulsed Corticosteroid Inhalation

Treatment of Chronic Rhinosinusitis with Pressure-Pulsed Corticosteroid Inhalation

Intranasal Administration of Drugs

Effect of Laser Treatment on Olfactory Dysfunction

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