2024
DOI: 10.1126/sciadv.adh3920
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Local and long-range input balance: A framework for investigating frontal cognitive circuit maturation in health and disease

Samuel J. Allen,
Hirofumi Morishita

Abstract: Frontal cortical circuits undergo prolonged maturation across childhood and adolescence; however, it remains unknown what specific changes are occurring at the circuit level to establish adult cognitive function. With the recent advent of circuit dissection techniques, it is now feasible to examine circuit-specific changes in connectivity, activity, and function in animal models. Here, we propose that the balance of local and long-range inputs onto frontal cognitive circuits is an understudied metric of circui… Show more

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