Biologically grounded brain-on-chip model identifies selective topographic reorganization within hyperexcitable neural networks
Maxime Poinsot,
Marine Dos Santos,
Baptiste Marthy
et al.
Abstract:Connectomics has revolutionized our understanding of brain function by emphasizing the importance of neural networks and their topographical organization. Corticostriatal circuits, which play a critical role in cognition and emotion, follow a precise topographic architecture essential for integrating and processing cortical information within the basal ganglia. Disruptions to this connectivity are often implicated in neurodevelopmental and psychiatric disorders such as obsessive compulsive disorders, schizophr… Show more
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