Local and Chronic Application of PTH Accelerates Tooth Movement in Rats

Soma, S.; Matsumoto, Shigeto; Higuchi, Y.; Takano‐Yamamoto, Teruko; Yamashita, Kazuhito; Kurisu, Kojiro; Iwamoto, Masahiro

doi:10.1177/00220345000790091301

Cited by 99 publications

(93 citation statements)

References 39 publications

(22 reference statements)

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“…Collins and Sinclair 12 reported that vitamin D 3 activated osteoclasts and rapid TM was observed. The local administration of prostaglandins, 13 osteocalcin, 14 or PTH 15 also induced orthodontic TM. However, because these drugs are rapidly flushed by blood circulation, daily systemic administration or daily local injection is needed.…”

Section: Introductionmentioning

confidence: 99%

Local RANKL gene transfer to the periodontal tissue accelerates orthodontic tooth movement

et al. 2006

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Section: Introductionmentioning

confidence: 99%

Local RANKL gene transfer to the periodontal tissue accelerates orthodontic tooth movement

et al. 2006

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“…into the subperiosteal area and 1.4 times as a result of subcutaneous administration of 4 μg/100 g m.c. 10,11 However, another study by the same authors does not confirm the efficacy of intermittent therapy. 12 Long-term research on the superiority of this method over other protocols is needed, as well as clinical trials.…”

Section: Parathormonementioning

confidence: 93%

Methods of accelerating orthodontic tooth movement: A review of contemporary literature

Kacprzak¹,

Strzecki²

2018

Dent. Med. Probl.

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Technological progress and the introduction of modern therapeutic methods are constantly changing contemporary orthodontics. More and more orthodontic patients are working adults, who expect satisfactory therapeutic effects as soon as possible, increasing the importance of methods accelerating tooth movement. The aim of this study was to review the current literature regarding methods of accelerating tooth movement and reducing the duration of the active phase of therapy. The literature was collected from the PubMed and EBSCO databases using "accelerated orthodontic tooth movement" as the search key words. The methods described were categorized as conservative and surgical. The pharmacological agents used in conservative treatment, such as growth hormone, parathyroid hormone, thyroxine, and vitamin D, are especially worth mentioning. They stimulate osteoclasts to increase resorption through a variety of mechanisms. Effective methods also include physical stimuli, e.g., vibrations or photobiomodulation. Most studies describing the effects of pharmacological agents were based on animal subjects and they may therefore lack clinical relevancy. Corticotomy and its modifications based on the regional acceleratory phenomenon (RAP) might prove to be a useful augmentation of orthodontic treatment, especially in adults, including patients with periodontal disease.

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“…This mechanism is taken advantage in accelerated orthodontics to fasten the tooth movement. Soma and coworkers [55,56] conducted experiments on rats and suggested that continuous administration of PTH is applicable to accelerate orthodontic tooth movement. Three animal case control studies [55][56][57] performed on parathyroid hormone used for AOTM.…”

Section: Contemporary Status Of Surgical Methodsmentioning

confidence: 99%

“…The variation amongst the studies seems to arise from variations in frequency of application of laser, intensity of laser, and method of force application on the tooth. Six studies performed on LLLT among those five were RCTs [50-54] done on humans and one study involve d cross sectional animal study [49].Drugs: Parathyroid hormone, Vitamin D, Prostaglandins and Relaxin are the most commonly used pharmacological agents to increase the rate of tooth movement and thus decrease the treatment duration (Table 4) [55][56][57][58][59][60][61][62][63][64][65][66]. Parathyroid hormone: Calcium homeostatsis and bone remodeling in the human body are mainly regulated by parathyroid hormone (PTH).…”

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confidence: 99%

Accelerated Orthodontics–An overview

Unnam¹,

Gs²,

P³

et al. 2018

J Dent Craniofac Res

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Orthodontic treatment is the reorganization of skeletal and/or dental tissues. Prolonged treatment duration is one of the main concerns of patients undergoing with fixed orthodontics. This extended orthodontic treatment in such particular cases has several drawbacks to the patients such as increased predisposition to root resorption, dental caries and gingival recession, etc. Consequently, researchers introduced few methods to accelerate the velocity of the tooth movement without any drawbacks. These kind of methods used in orthodontics were popular as accelerated orthodontics. Accelerated orthodontics could be possible by mechanical stimulation or device assisted therapy, surgical therapy and by the use of pharmacological agents. The purpose of the present manuscript was to describe and evaluate the methods used in accelerated orthodontics.Keywords: Accelerated orthodontics; Conventional orthodontic treatment; Corticotomy; Tooth movement IntroductionThe movement of tooth orthodontically happens under mechanical forces depends upon the alteration of the tissues surrounding its radicular part. These mechanical force creates a response in cellular component of surrounding periodontal ligament (PDL), that creates resorption in bone on pressure side and deposition of bone on the either side (tension side) [1]. This is an inflammatory process and the rate limiting factor for tooth movement is bone resorption at the bone and periodontal ligament interface [2]. Orthodontic movement can be controlled by the size of the applied force and the biological responses from the periodontal ligament [3]. This orthodontic force would cause inflammation around the periodontal ligament due to changes in blood flow, leading to the secretion of different inflammatory mediators like colony-stimulating factors, cytokines, growth factor, arachidonic acid metabolites and neurotransmitters. As a result of these secretions, remodelling of the bone occurs [4,5].Macrophage colony stimulating factor (M-CSF), Receptor activator of nuclear factor kappa B ligand (RANKL), and osteoprotegerin (OPG) by osteoblasts play key roles in tooth movement has been showed in Figure 1. RANKL binds to its receptor, RANK (Receptor activator of nuclear factor kappa B), on the surface of osteoclastic cells at developmental stage. The RANKL/RANK binding is very critical for the function, differentiation, and survival of osteoclasts. Fixed orthodontics could last for 24 to 36 months which further poses the risk of complications associated with the treatment such as external root resorption, periodontal problems and patient compliance. Orthodontists are persistently motivated towards developing potential strategies to enhance the rate of orthodontic tooth movement [6][7][8] AOTM has been preferred for its numerous prospective benefits like shorter treatment duration, differential tooth movement, enhanced envelope of tooth movement, improved post treatment stability and reduced side effects [9]. Attempts to AOTM can be dated back to the 1890s, where Cunningh...

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Local and Chronic Application of PTH Accelerates Tooth Movement in Rats

Cited by 99 publications

References 39 publications

Local RANKL gene transfer to the periodontal tissue accelerates orthodontic tooth movement

Local RANKL gene transfer to the periodontal tissue accelerates orthodontic tooth movement

Methods of accelerating orthodontic tooth movement: A review of contemporary literature

Accelerated Orthodontics–An overview

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