Local Anaesthetic Activity of the Essential Oil of Lavandula angustifolia

Ghelardini, Carla; Galeotti, Nicoletta; Salvatore, Giuseppe; Mazzanti, Gabriela

doi:10.1055/s-1999-14045

Cited by 163 publications

(86 citation statements)

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“…Many members of the family Lamiaceae are well-known for their pharmacological effects such as anticonvulsant, sedative, antispasmodic, analgesic, antioxidant, or local anaesthetic activity (Ghelardini et al, 1999;Lis-Balchin and Hart, 1999;Hosseinzadeh et al, 2000;Kovatcheva et al, 2001). Phytochemical analyses of lavender have demonstrated the presence of many monoterpenes (especially linalyl acetate, linalool), which are responsible for its pharmacologic activity (Lis-Balchin and Hart, 1999;Gilani et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

In vitro cytotoxicity screening of wild plant extracts from Saudi Arabia on human breast adenocarcinoma cells

Ali¹,

Farah²,

Al-Hemaid³

et al. 2014

Genet. Mol. Res.

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ABSTRACT. This study investigated the in vitro anticancer activities of a total of 14 wild angiosperms collected in Saudi Arabia. The cytotoxic activity of each extract was assessed against human breast adenocarcinoma (MCF-7) cell lines by using the MTT assay. Among the plants screened, the potential cytotoxic activity exhibited by the extract of Lavandula dentata (Lamiaceae) was identified, and we analyzed its anticancer potential by testing antiproliferative and apoptotic activity. Our results clearly show that ethanolic extract of L. dentata exhibits promising cytotoxic activity with an IC 50 value of 39 µg/mL. Analysis of cell morphological changes, DNA fragmentation and apoptosis (using an Annexin V assay) also confirmed the apoptotic effect of L. dentata extract, and thus, our data call for further investigations to determine the active chemical constituent(s) and their mechanisms of inducing apoptosis.

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Section: Discussionmentioning

confidence: 99%

In vitro cytotoxicity screening of wild plant extracts from Saudi Arabia on human breast adenocarcinoma cells

Ali¹,

Farah²,

Al-Hemaid³

et al. 2014

Genet. Mol. Res.

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“…The in vitro studies have proven this essential oil to have analgesic activity [44], and experiments on rabbits have revealed its anesthetic properties [45]. Massage with lavender essential oil reduced the need for pain relievers among young patients with HIV, and in some cases removed pain completely [46].…”

Section: Properties and Appliancementioning

confidence: 99%

Composition, biological properties and therapeutic effects of lavender (Lavandula angustifolia L). A review

2014

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S u m m a r yLavender (Lavandula angustifolia) is a shrub of the family Lamiaceae, native to the Mediterranean region. The material used for herbal purposes includes lavender flowers (Lavandula flores) containing essential oil (3%), anthocyanins, phytosterols, sugars, minerals, and tannins. The qualitative and quantitative composition of the essential oil of lavender is variable and depends on genotype, growing location, climatic conditions, propagation, and morphological features. The essential oil contains over 300 chemical compounds. The dominant components are linalool, linalyl acetate, terpinen-4-ol, acetate lavandulol, ocimene, and cineole. Lavender essential oil has good antioxidant and antimicrobial activities and a significant positive effect on the digestive and nervous systems. Lavender extract prevents dementia and may inhibit the growth of cancer cells, while lavender hydrolate is recommended for the treatment of skin problems and burns.

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“…Citrus limon é rico em limoneno, β-pineno, γ-terpineno, terpinoleno, neral e geranial (Vekiari et al, 2002;Bisset;Wichtl, 2001;Ghelardini et al, 1999). Dados farmacológicos: O óleo volátil causou inibição no crescimento de Candida albicans (Ezzat, 2001).…”

Section: Citrus Limon (L) Osbeck (Rutaceae) -Constituintes Químicos:unclassified

Dados químicos e farmacológicos sobre as plantas utilizadas como medicinais pela comunidade do bairro Ponta Grossa, Porto Alegre, Rio Grande do Sul

Vendruscolo¹,

Rates²,

Mentz³

2005

Rev. bras. farmacogn.

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Para estas espécies foi realizada uma revisão bibliográfi ca, buscando estudos sobre sua constituição química e atividade farmacológica. Para todas as espécies foram encontrados dados químicos e para nove delas dados de atividade farmacológica. Foram encontrados estudos clínicos para quatro espécies e usos terapêuticos aprovados por organismos internacionais para três espécies. Efeitos adversos foram encontrados, na literatura, para cinco das dez espécies pesquisadas e para seis destas, o uso durante a gestação é desaconselhado.Unitermos: Etnobotânica, plantas medicinais, farmacologia.ABSTRACT: "Chemical and pharmacologic data on medicinal plants used by the community of the Ponta Grossa neighborhood, Porto Alegre, Rio Grande do Sul, Brazil". The ten most important species among all plants used as medicinal by the residents and Communitary Agents of Health from the Family Health Offi ce of Ponta Grossa neighborhood, Porto Alegre, Rio Grande do Sul, Brazil were selected. A bibliographical review for these species was accomplished, fi nding studies about the chemical constitution for all species and some pharmacologic activity for nine of them. Clinical studies for four species and therapeutic uses approved by international organisms for three species were found. It was verifi ed that according to the literature, adverse effects for fi ve of the ten researched species and for six of these the use is dissuaded during the gestation.Keywords: Ethnobotany, medicinal plants, pharmacology. INTRODUÇÃONo Brasil, a possibilidade de implementação da fi toterapia no sistema público de saúde vem sendo considerada desde 1988 (CIPLAN) e faz parte das diretrizes da I Conferência Nacional de Assistência Farmacêutica (CNMAF, 2003). A partir de então, várias inicativas pontuais para estabelecer a fi toterapia na rede pública de sáude vêm ocorrendo, com destaque para o Programa de Fitoterapia do Ceará, alicerçado no Projeto Farmácias Vivas, idealizado pelo Prof. Francisco José de Abreu Matos (Matos et al., 2001). No entanto, para a maioria das plantas nativas não existem estudos científi cos e o uso no Brasil é baseado principalmente na tradicionalidade. A OMS reconhece a importância do uso tradicional, mas para a utilização de uma planta com fi nalidade terapêutica, em nível de saúde pública, é fundamental o estabelecimento de sua segurança, efi cácia e garantia de qualidade das preparações (Lapa et al., 2003; WHO, 2002;Rates, 2001). O uso inadequado destes recursos terapêuticos pode originar efeitos adversos retardados e/ou assintomáticos, interações medicamentosas ainda não estudadas e difi cilmente reconhecidas, além de retardar o diagnóstico e tratamento apropriado (Cañigueral; Vila, 2003;Rates, 2001). Nestes termos, o emprego no atendimento primário à saúde pode gerar um impacto social (Lapa et al., 2003), com aumento de gastos nos serviços públicos de saúde, visto que as plantas com maior volume de estudos científi cos que garantam efi cácia e segurança constituem matéria-prima importada, o que torna urgente a busca de inform...

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Local Anaesthetic Activity of the Essential Oil of Lavandula angustifolia

Cited by 163 publications

References 0 publications

In vitro cytotoxicity screening of wild plant extracts from Saudi Arabia on human breast adenocarcinoma cells

In vitro cytotoxicity screening of wild plant extracts from Saudi Arabia on human breast adenocarcinoma cells

Composition, biological properties and therapeutic effects of lavender (Lavandula angustifolia L). A review

Dados químicos e farmacológicos sobre as plantas utilizadas como medicinais pela comunidade do bairro Ponta Grossa, Porto Alegre, Rio Grande do Sul

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