“…These pharmacological actions are similar to those of nicotine, and for this reason lobeline preparations have been recommended as an aid to giving up smoking. Some success has been claimed when large doses of the order of 8-10 mg. of lobeline sulphate are given orally (Dorsey, 1936;Wright and Littauer, 1937) or intramuscularly (Ejrup, 1956;Jost and Jochum, 1959). With these large doses tachycardia, epigastric pain, nausea, vomiting, and other unpleasant side-effects often occurred.…”