Lobeline for smoking cessation

Abstract

Can lobeline help people to quit smokingLobeline is an alkaloid derived from the leaves of an Indian tobacco plant, and has been widely used in commercial smoking remedies. Its adverse e ects include dizziness, nausea, and vomiting, and tablets and pastilles containing Lobeline may lead to throat irritation. The Lobeline for smoking cessation (Review)

Other Pharmacological and Developing Treatments in Smoking Cessation/Nicotine Vaccines

“…Varenicline cysticine'den sonra geliştirilmiş olmakla birlikte birinci basamak tedavide yer almaktadır. Cystisine'in sigara bırakmadaki etkileri üzerine yapılmış randomize kontrollü üç çalışma, dianicline ve lobeline ile yapılmış placebo kontrollü birer çalışma bulunmaktadır ve bu çalışmalarda da dianicline ve lobeline'in uzun süreli sigara bırakma başarısı gös-terilemediği gibi lobeline ile bulantı, kusma ve boğaz irritasyonu gibi yan etkiler de bildirilmiştir (4,10,11) . Cystisine: cystisus laburnum bitkisinden elde edilen bir alkaloiddir ve nikotin reseptör parsiyel agonistidir.…”

Antiepileptic activity of lobeline isolated from the leaf of Lobelia nicotianaefolia and its effect on brain GABA level in mice

“…Methods: The anticonvulsant activity of the isolated lobeline (5,10,20 and 30 mg/kg, i.p.) was investigated in PTZ and strychnine induced seizures in mice and the effect of isolated lobeline on brain GABA level in seizures induced by PTZ.…”

“…The mortality was also prevented in the test group of animals. In biochemical evaluation, isolated lobeline (5, 10 and 20 mg/kg, i.p.) significantly increased the brain GABA level.…”

“…Contents lists available at ScienceDirect reports [10] . In a recent patent, studies on a new formulation of drugs to deliver an effective amount of lobeline to sublingual mucosa were done.…”

Review of alternative practices to cigarette smoking and nicotine replacement therapy: how safe are they?

“…25 Other non-herbal products that contain nicotine and flavourings have been marketed as cessation aids and alternatives to cigarette smoking in Europe, the USA and Asia. 26 Despite the claims of effectiveness, there is no documented evidence of efficacy for most of them. In light of the lack of documented efficacy, these products cannot be promoted as effective alternatives to cigarette smoking.…”