Loading of doxorubicin into surface-attached stimuli-responsive microgels and its subsequent release under different conditions

Pergushov, Dmitry V.; Sigolaeva, Larisa V.; Балабушевич, Н. Г.; Sharifullin, Timur Z.; Noyong, Michael; Richtering, Walter

doi:10.1016/j.polymer.2020.123227

Cited by 22 publications

(22 citation statements)

References 52 publications

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“…In the field of the controlled release of active compounds, the role of nanotechnology has driven the development of micro/nanoscopic polymeric systems (polymer–drug conjugates, micelles, dendritic structures) among which microgels have a highlighted role. The possibility to tune the microgel mesh size, that is, porosity, in addition to the composition, colloidal stability, and elasticity, has significantly contributed to the development of microgels as drug delivery or active compound carriers [ 50 , 51 , 52 , 53 ]. These systems are the basis of what is now known as nanomedicine, whose research in the last decade has been mainly directed toward the development of theragnostic systems, a combination of a therapeutic and diagnostic functions.…”

Section: Applications Of Microgelsmentioning

confidence: 99%

Rheology Applied to Microgels: Brief (Revision of the) State of the Art

Echeverría

Mijangos

2022

Polymers

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The ability of polymer microgels to rapidly respond to external stimuli is of great interest in sensors, lubricants, and biomedical applications, among others. In most of their uses, microgels are subjected to shear, deformation, and compression forces or a combination of them, leading to variations in their rheological properties. This review article mainly refers to the rheology of microgels, from the hard sphere versus soft particles’ model. It clearly describes the scaling theories and fractal structure formation, in particular, the Shih et al. and Wu and Morbidelli models as a tool to determine the interactions among microgel particles and, thus, the viscoelastic properties. Additionally, the most recent advances on the characterization of microgels’ single-particle interactions are also described. The review starts with the definition of microgels, and a brief introduction addresses the preparation and applications of microgels and hybrid microgels.

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Section: Applications Of Microgelsmentioning

confidence: 99%

Rheology Applied to Microgels: Brief (Revision of the) State of the Art

Echeverría

Mijangos

2022

Polymers

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“…In another work, Pergushov et al controlled the uptake on and release of DOX from P(NIPAm-co-AA) microgel films in solutions at different ionic strengths: when deposited at high temperature, the microgels formed a uniform densely packed film, wherein the AA moieties adsorbed cationic DOX via electrostatic interactions at neutral pH. [231] The addition of NaCl or a polycation (i.e., quaternized poly(4-vinylpyridine)) to the surrounding solution disrupted DOX binding; it triggered its immediate release from the swollen microgels, affording 90% release in under 30 min.…”

Section: Controlled Releasementioning

confidence: 99%

Surface‐Bound Microgels for Separation, Sensing, and Biomedical Applications

Cutright

Harris

Ramesh

et al. 2021

Adv Funct Materials

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This study presents a comprehensive survey of microgel-coated materials and their functional behavior, describing the complex interplay between the physicochemical and mechanical properties of the microgels and the chemical and morphological features of substrates. The cited literature is articulated in four main sections: i) properties of 2D and 3D substrates, ii) synthesis, modification, and characterization of the microgels, iii) deposition techniques and surface patterning, and iv) application of microgel-coated surfaces focusing on separations, sensing, and biomedical applications. Each section discussesby way of principles and examples -how the various design parameters work in concert to deliver functionality to the composite systems. The case studies presented herein are viewed through a multi-scale lens. At the molecular level, the surface chemistry and the monomer make-up of the microgels endow responsiveness to environmental and artificial physical and chemical cues. At the micro-scale, the response effects shifts in size, mechanical, and optical properties, and affinity towards species in the surrounding liquid medium, ranging from small molecules to cells. These phenomena culminate at the macro-scale in measurable, reversible, and reproducible effects, aiming in a myriad of directions, from lab-scale to industrial applications.

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“…Regarding the use of microgels as drug-delivery vehicles, many different studies have been performed with varying drugs, ranging from lysozyme [ 24 ] over the more hydrophilic drugs dopamine, naproxen, desipramine, dibucaine, acetaminophen [ 25 ], and

-aescin [ 26 ] to the hydrophobic doxorubicin (DOX) [ 27 , 28 , 29 , 30 , 31 , 32 , 33 ]. Just from these representative examples, it can be stated that the structure of microgels, which often exhibit a rather hydrophobic, cross-linker rich core region and a rather hydrophilic corona [ 34 ], enables these particles to act as carriers for a variety of hydrophilic and hydrophobic drugs.…”

Section: Introductionmentioning

confidence: 99%

Temperature Controlled Loading and Release of the Anti-Inflammatory Drug Cannabidiol by Smart Microgels

Dirksen

Kinder²,

Brändel

et al. 2021

Molecules

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CBD is a promising candidate for treatment of many diseases and plays a major role in the growing trend to produce high-end drugs from natural, renewable resources. In the present work, we demonstrate a way to incorporate the anti-inflammatory drug CBD into smart microgel particles. The copolymer microgels that we chose as carrier systems exhibit a volume phase transition temperature of 39 ∘C, which is just above normal body temperature and makes them ideal candidates for hyperthermia treatment. While a simple loading route of CBD was not successful due to the enormous hydrophobicity of CBD, an alternative route was developed by immersing the microgels in ethanol. Despite the expected loss of thermoresponsive behaviour of the microgel matrix due to the solvent exchange, a temperature-dependent release of CBD was detected by the material, creating an interesting question of interactions between CBD and the microgel particles in ethanol. Furthermore, the method developed for loading of the microgel particles with CBD in ethanol was further improved by a subsequent transfer of the loaded particles into water, which proves to be an even more promising approach due to the successful temperature-dependent release of the drug above the collapse temperature of the microgels.

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Loading of doxorubicin into surface-attached stimuli-responsive microgels and its subsequent release under different conditions

Cited by 22 publications

References 52 publications

Rheology Applied to Microgels: Brief (Revision of the) State of the Art

Rheology Applied to Microgels: Brief (Revision of the) State of the Art

Surface‐Bound Microgels for Separation, Sensing, and Biomedical Applications

Temperature Controlled Loading and Release of the Anti-Inflammatory Drug Cannabidiol by Smart Microgels

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