LncRNA uc003fir promotes CCL5 expression and negatively affects proliferation and migration of trophoblast cells in preeclampsia

Zhang, Pengjie; Chen, Xiong-Hui; Zhang, Yueming; Xu, Tao; Na, Li; Tao, Jianying; Xu, Zhice

doi:10.1016/j.preghy.2018.08.449

Cited by 21 publications

(17 citation statements)

References 28 publications

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“…LINC-HELLP was discovered to be linked to trophoblast proliferation and invasion, and LINC-HELLP mutation could attenuate the differentiation of trophoblasts [48]. LncRNA uc003fir was upexpressed in the vessels of PE placentas in comparison with the normal ones through the regulation of “HIF1- α –lncRNA uc003fir–CCL5” axis, which resulted into the development of PE [49].…”

Section: Lncrnas Affect Cellular Functions Of Trophoblast Cellsmentioning

confidence: 99%

Long Noncoding RNA in Preeclampsia: Transcriptional Noise or Innovative Indicators?

Yang

Meng

2019

BioMed Research International

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Preeclampsia (PE) is termed as an obstetric issue that is characterized by hypertension (≧140/90 mm Hg), together with proteinuria following 20 weeks of pregnancy. Until today, PE still constitutes a severe threat to the lives of both the mothers and fetuses. In the past, long noncoding RNAs (lncRNAs) were considered as the transcriptional noise. However, some investigations have indicated that lncRNAs could be used as innovative indicators in PE. The current review aims to discuss the relationship between lncRNAs and PE in recent years. According to the retrieved data, we concluded that lncRNAs can exert an impact on both the occurrence and development of PE through the changes in the biological functions of trophoblasts, immune regulation, epigenetic regulation, decidualization, and energy metabolism. The mechanisms of lncRNAs in PE will help us to better understand the pathogenesis of PE and help us to find targets for predicting and diagnosing PE in the future.

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Section: Lncrnas Affect Cellular Functions Of Trophoblast Cellsmentioning

confidence: 99%

Long Noncoding RNA in Preeclampsia: Transcriptional Noise or Innovative Indicators?

Yang

Meng

2019

BioMed Research International

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“…9,10 To date, lncRNAs have been proved to be associated with diverse diseases, including PE. [11][12][13] In these cases, lncRNAs are implicated in proliferation, apoptosis, invasion, and migration of trophoblasts cells, suggesting a role of lncRNAs in the development of PE.…”

Section: Introductionmentioning

confidence: 99%

Silencing of AFAP1‐AS1 lncRNA impairs cell proliferation and migration by epigenetically promoting DUSP5 expression in pre‐eclampsia

Zhang

Zou

Tang

et al. 2021

J of Cellular Biochemistry

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As a unique and common obstetric complication of pregnant women, pre‐eclampsia (PE) has been the first leading cause of maternal and perinatal morbidity and mortality in the world. Mounting studies have demonstrated that an abnormality of long noncoding RNA (lncRNA) expression was related to the pathological process of PE. Here, we showed that lncRNA AFAP1‐AS1 was markedly downregulated in pre‐eclamptic placentas. We further investigated the mechanism underlying the regulatory role of AFAP1‐AS1 in PE using human trophoblast cells. In vitro functional assays revealed that AFAP1‐AS1 knockdown inhibited trophoblast proliferation, migration, and invasion. Moreover, AFAP1‐AS1 interacts with EZH2 and inhibits DUSP5 expression through modulating H3K27m3 in the DUSP5 promoter of trophoblast cells, thus being involved in PE pathogenesis. Overall, these findings suggest that AFAP1‐AS1 could potentially become a prognostic biomarker as well as a new therapeutic target for PE.

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“…lncRNAs are capable of regulating the development and metabolism of several cellular activities at the epigenetic, transcriptional and post-transcriptional levels (30). A number of studies have shown that the abnormal expression of lncRNAs in placental tissues during pregnancy is closely related to the onset of pre-eclampsia (31,32). He et al (16) reported that 738 lncRNAs were differentially expressed in the placental tissues of patients with pre-eclampsia, including 479 that were upregulated and 259 that were downregulated.…”

Section: Discussionmentioning

confidence: 99%

Long non‑coding RNA NR_002794 is upregulated in pre‑eclampsia and regulates the proliferation, apoptosis and invasion of trophoblast cells

Liang

et al. 2019

Mol Med Report

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Pre-eclampsia is a common complication during pregnancy, characterized by hypertension and proteinuria. The pathogenesis of pre-eclampsia is not fully understood. Studies on the maternal spiral artery have led scientists to consider that the ineffective infiltration of placental trophoblast cells may be a primary cause of pre-eclampsia. The present study aimed to investigate the differences in the profiles of long non-coding RNAs (lncRNAs) between the placentas of patients with pre-eclampsia and those of healthy pregnant women. The involvement of the differentially expressed lncRNAs in the biological activity of trophoblast cells was also assessed. A total of 26 differentially expressed lncRNAs were identified between the pre-eclampsia and healthy groups. Upregulation of NR_002794 was found in tissues from patients with pre-eclampsia. In SWAN71 trophoblast cells, NR_002794 had suppressive effects on proliferation and migration, and resulted in an increased rate of apoptosis. Furthermore, lncRNA NR_002794 had no effect on the phagocytosis of trophoblast cells. The present study suggested that abnormal levels of NR_002794 may lead to atypical conditions in trophoblast cells, which may be associated with the failure of maternal spiral artery remodeling during pregnancy and, consequently, with the development of pre-eclampsia.

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LncRNA uc003fir promotes CCL5 expression and negatively affects proliferation and migration of trophoblast cells in preeclampsia

Cited by 21 publications

References 28 publications

Long Noncoding RNA in Preeclampsia: Transcriptional Noise or Innovative Indicators?

Long Noncoding RNA in Preeclampsia: Transcriptional Noise or Innovative Indicators?

Silencing of AFAP1‐AS1 lncRNA impairs cell proliferation and migration by epigenetically promoting DUSP5 expression in pre‐eclampsia

Long non‑coding RNA NR_002794 is upregulated in pre‑eclampsia and regulates the proliferation, apoptosis and invasion of trophoblast cells

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