LncRNA SOX2-OT regulates miR-192-5p/RAB2A axis and ERK pathway to promote glioblastoma cell growth

Wang, Hongcai; Hu, Qinglei; Tong, Yi-Lei; Li, Shiwei; Chen, Maosong; Wang, Boding; Li, Haimeng

doi:10.1080/15384101.2021.1965722

Cited by 7 publications

(7 citation statements)

References 39 publications

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“…Another ceRNA axis, SOX2-OT/miR-30d-5p/PDK1, involving SOX2-OT in uences NSCLC cell proliferation, migration, and invasion [54]. The ERK signaling pathway and the miR192-5p/RAB2A axis are regulated by SOX2-OT [29]. SOX2-OT knockdown could increase apoptosis and decrease laryngeal cancer cell proliferation, migration, and invasion by focusing on miR-654 [28].…”

Section: Discussionmentioning

confidence: 99%

Clinical Significance of LncRNAs SOX2-OT and NEAT1 in Esophageal Squamous Cell Carcinoma

Kumar,

Mohanta,

Rana

et al. 2024

Preprint

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Despite strides in diagnostic and therapeutic approaches for ESCC, patient survival rates remain relatively low. Recent studies highlight the pivotal role of long non-coding RNAs (lncRNAs) in regulating diverse cellular activities in humans. Dysregulated lncRNAs have emerged as potential diagnostic indicators across various cancers, including ESCC. However, further research is necessary to effectively leverage ESCC-associated lncRNAs in clinical settings. Understanding their clinical significance for ESCC diagnosis and their mechanisms can pave the way for more effective therapeutic strategies. Our qRT-PCR observations indicated significant downregulation of SOX2-OT and NEAT1 in ESCC blood samples (SOX2-OT down by ~ 2.02-fold and NEAT1 down by ~ 1.53-fold). The decreased expression of SOX2-OT and NEAT1 shows promise in differentiating ESCC patients from healthy individuals, as demonstrated by Receiver Operating Characteristics (ROC) curves and Area Under the Curve (AUC) values (AUC: SOX2-OT = 0.736, NEAT1 = 0.621) for ESCC diagnosis. Subsequent investigations explored the relationship between aberrant SOX2-OT and NEAT1 expression in ESCC patients and various clinicopathological features, including age, gender, smoking habits, alcohol consumption, hot beverage intake, tumor grade, and TNM stages. In-depth in-silico analysis unveiled the involvement of SOX2-OT and NEAT1 in miRNA sponging through the mTOR and MAPK pathways. In contrast, co-expression network analysis identified genes co-expressed with these lncRNA targets. This groundwork lays the foundation for future endeavours aimed at identifying and predicting ESCC prognosis by leveraging SOX2-OT and NEAT1. By thoroughly investigating the functions of these lncRNAs, we aim to deepen our understanding of their potential as diagnostic markers and their role in facilitating effective therapeutic interventions for esophageal squamous cell carcinoma (ESCC) within clinical contexts.

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Section: Discussionmentioning

confidence: 99%

Clinical Significance of LncRNAs SOX2-OT and NEAT1 in Esophageal Squamous Cell Carcinoma

Kumar,

Mohanta,

Rana

et al. 2024

Preprint

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“…Recently, 12 lncRNA genes related to m6A/m5C/m1A/m7G have been proposed [ 80 ] that can accurately predict the prognosis of patients and set the direction for promising immunotherapy strategies in the future. For example, lncRNA SOX2OT [ 72 , 73 , 74 ] may be a promising target for glioblastoma therapy, including TMZ-resistant. The same is true for other lncRNAs mediating post-transcriptional changes in individual molecules and cell cycle regulation—JPX [ 70 ], lncGRS-1 [ 78 ] and FOXM1-AS [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, SOX2OT itself may promote cancer progression through sponging miRNA-144-3p, which induces cell apoptosis and targets the c-MET oncogene. Several studies showed a connection between SOX2OT and the activation of the PI3K/Akt signaling pathway through the sponging of definite miRNA [ 73 , 74 ]. Unfortunately, the SOX2OT–SOX2 interaction results in increasing the SOX2 level, leading to higher TMZ resistance of glioblastoma.…”

Section: Non-coding Rna and Apoptosismentioning

confidence: 99%

Post-Transcriptional Modifications of RNA as Regulators of Apoptosis in Glioblastoma

Dome

Дымова

Richter

et al. 2022

IJMS

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This review is devoted to changes in the post-transcriptional maturation of RNA in human glioblastoma cells, which leads to disruption of the normal course of apoptosis in them. The review thoroughly highlights the latest information on both post-transcriptional modifications of certain regulatory RNAs, associated with the process of apoptosis, presents data on the features of apoptosis in glioblastoma cells, and shows the relationship between regulatory RNAs and the apoptosis in tumor cells. In conclusion, potential target candidates are presented that are necessary for the development of new drugs for the treatment of glioblastoma.

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“…SOX2-OT shows upregulation in GBM and its silencing is correlated with apoptosis. LncRNA SOX2-OT suppresses miRNA-192–5p to overexpress RAB2A, evoking ERK and subsequent elevation in proliferation of GBM [ 97 ].…”

Section: Lncrnas In Proliferation and Invasionmentioning

confidence: 99%

Shedding light on function of long non-coding RNAs (lncRNAs) in glioblastoma

Hashemi,

Mousavian Roshanzamir,

Orouei

et al. 2024

Non-coding RNA Research

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LncRNA SOX2-OT regulates miR-192-5p/RAB2A axis and ERK pathway to promote glioblastoma cell growth

Cited by 7 publications

References 39 publications

Clinical Significance of LncRNAs SOX2-OT and NEAT1 in Esophageal Squamous Cell Carcinoma

Clinical Significance of LncRNAs SOX2-OT and NEAT1 in Esophageal Squamous Cell Carcinoma

Post-Transcriptional Modifications of RNA as Regulators of Apoptosis in Glioblastoma

Shedding light on function of long non-coding RNAs (lncRNAs) in glioblastoma

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