lncRNA-SNHG7 promotes the proliferation, migration and invasion and inhibits apoptosis of lung cancer cells by enhancing the FAIM2 expression

She, Kelin; Huang, Jun; Hong-bin, Zhou; Huang, Tonghai; Chen, Guojun; He, Jianxing

doi:10.3892/or.2016.5105

Cited by 86 publications

(75 citation statements)

References 42 publications

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“…The high expression of lnc-HOTAIR can promote the proliferation, migration and invasion of tumor cells, while the unlimited proliferation of cells is closely related to the occurrence and development of cancer [50]. LncRNA-SNHG7 promotes the proliferation of lung cancer cells by enhancing the FAIM2 expression [51]. Our results indicated lncRNA-OBFC2A affected cell proliferation by regulating the expression of proliferation-related genes in AHH-1 cells.…”

Section: Discussionmentioning

confidence: 87%

Benzene and its metabolite decreases cell proliferation via LncRNA-OBFC2A-mediated anti-proliferation effect involving NOTCH1 and KLF15

et al. 2017

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LncRNA has been considered to play a crucial role in the progression of several diseases by affecting cell proliferation. However, its role in benzene toxicity remains unclear. Our study showed that the expression of lncRNA-OBFC2A increased accompanied with the change of cell proliferation related-genes in benzene-exposed workers. In vitro experiments, 1,4-Benzoquinone dose-dependently inhibited cell proliferation and simultaneously caused the decrease of NOTCH1 expression and the increase of KLF15 in AHH-1 cell lines. Meanwhile, 1, 4-Benzoquinone obviously increased the expression of lncRNA-OBFC2A, which was consistent with our previous population results. Therefore, we propose that lncRNA-OBFC2A is involved in benzene toxicity by regulating cell proliferation. Further, we successfully constructed a lentivirus model of interfering the expression of lncRNA-OBFC2A. After interfering lncRNA-OBFC2A, the cell proliferation inhibition and the expression of NOTCH1 and KLF15 induced by 1, 4-Benzoquinone were reversed. Subsequently, RNA fluorescence in situ Hybridization assay showed that lncRNA-OBFC2A was located in cell nuclei. These results suggest that benzene and its metabolite decreases cell proliferation via LncRNA-OBFC2A-mediated anti-proliferation effect involving NOTCH1 and KLF15. LncRNA-OBFC2A can be a potential biomarker for benzene toxicity.

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Section: Discussionmentioning

confidence: 87%

Benzene and its metabolite decreases cell proliferation via LncRNA-OBFC2A-mediated anti-proliferation effect involving NOTCH1 and KLF15

et al. 2017

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“…Recent studies reveal that PVT1 is overexpressed in multiple cancers and correlated with cancer progression, including colorectal cancer , gastric cancer , and cervical cancer . In addition, a recent study showed that SNHG7 overexpression promotes cell migration and invasion in lung cancer by enhancing the FAIM2 expression . Here, we firstly analyzed PVT1 and SNHG7 expression levels in HCC cell lines using CCLE data , and the results showed that HuH1 cell has highest PVT1 and SNHG7 expression levels (Fig.…”

Section: Resultsmentioning

confidence: 93%

A comprehensive genome‐wide analysis of long noncoding RNA expression profile in hepatocellular carcinoma

Cui

Zhang

et al. 2017

Cancer Medicine

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Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide, especially in East Asia and China. Long noncoding RNAs (lncRNAs) are emerging as critical regulators that may be involved in the development and progression of cancers in humans. However, the contributions of lncRNAs to HCC development, metastasis, and recurrence remain largely unknown. In this study, we comprehensively investigated lncRNA expression profile in HCC and normal tissues using TCGA RNA sequencing data, one RNA sequencing dataset, and two microarray datasets from GEO. By analyzing these four datasets, we identified hundreds of expression‐dysregulated lncRNAs in HCC tissues compared with normal tissues. Genomic copy number variation analysis showed that many of those lncRNAs disorder are related to the copy number amplification or deletion. Moreover, several lncRNAs expression levels are associated with HCC patients' overall and recurrence‐free survival, such as RP1‐228H13.5, TMCC1‐AS1, LINC00205, and RP11‐307C12.11. Furthermore, we identified two lncRNAs termed PVT1 and SNHG7 that may be involved in HCC cells metastasis by comparing lncRNAs expression profiles between early recurrence HCC tissues with metastasis and late recurrence HCC tissues without metastasis. Finally, loss‐of‐function assays confirmed that knockdown of SNHG7 and PVT1 impaired HCC cells invasion. Taken together, these findings may provide a valuable resource for further identification of novel biomarkers and therapeutic targets for HCC patients.

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“…It has been proven in extensive researches on cancers that the differentially expressed lncRNA pattern was obviously associated with the pathogenesis of various malignant tumors3435. In our study, nine lncRNAs meta-signature were incorporated for integrated analysis through a series of data mining and calculation.…”

Section: Discussionmentioning

confidence: 99%

Meta-signature LncRNAs serve as novel biomarkers for colorectal cancer: integrated bioinformatics analysis, experimental validation and diagnostic evaluation

Dai

Chen

et al. 2017

Sci Rep

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The aim of this study is to explore the differentially expressed lncRNAs, which may have potential biological function and diagnostic value in colorectal cancer (CRC). Through integrated data mining, we finally identified nine differentially expressed lncRNAs and their potential mRNA targets. After a series of bioinformatics analyses, we screened significant pathways and GO terms that are related to the up-regulated and down-regulated transcripts respectively. Meanwhile, the nine lncRNAs were validated in 30 paired tissues and cell lines by qRT-PCR and the results were basically consistent with the microarray data. We also tested the nine lncRNAs in the serum of 30 CRC patients matched with the CRC tissue, 30 non-cancer patients and 30 health controls. Finally, we found that BLACAT1 was significant for the diagnosis of CRC. The area under the curve (AUC), sensitivity and specificity were 0.858 (95% CI: 0.765–0.951), 83.3% and 76.7% respectively between CRC patients and health controls. Moreover, BLACAT1 also had distinct value to discriminate CRC from other non-cancer diseases. The results indicated that the differentially expressed lncRNAs and their potential target transcripts could be considered as potential therapeutic targets for CRC patients. Meanwhile, lncRNA BLACAT1 might represent a new supplementary biomarker for the diagnosis of CRC.

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lncRNA-SNHG7 promotes the proliferation, migration and invasion and inhibits apoptosis of lung cancer cells by enhancing the FAIM2 expression

Cited by 86 publications

References 42 publications

Benzene and its metabolite decreases cell proliferation via LncRNA-OBFC2A-mediated anti-proliferation effect involving NOTCH1 and KLF15

Benzene and its metabolite decreases cell proliferation via LncRNA-OBFC2A-mediated anti-proliferation effect involving NOTCH1 and KLF15

A comprehensive genome‐wide analysis of long noncoding RNA expression profile in hepatocellular carcinoma

Meta-signature LncRNAs serve as novel biomarkers for colorectal cancer: integrated bioinformatics analysis, experimental validation and diagnostic evaluation

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