lncRNA‑SNHG7‑003 inhibits the proliferation, migration and invasion of vascular smooth muscle cells by targeting the miR‑1306‑5p/SIRT7 signaling pathway

Zheng, Jianghua; Tan, Qiang; Chen, Hang; Chen, Kai; Wang, Haifei; Chen, Zhilong; Xi, Yong; Yin, Hongshun; Lai, Kun; Liu, Yujuan

doi:10.3892/ijmm.2020.4821

Cited by 28 publications

(16 citation statements)

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“…Given that miR-1306-5p targets SIRT7 gene, we speculated that it regulates progression of OS by binding SIRT7. 10 Indeed, further analyses revealed a strong negative correlation between miR-1306-5p and SIRT7 expression in OS tissue ( Figure 6A ; r = - 0.3177; P < 0.01). Interestingly, we observed a positive correlation between AC007207.2 and SIRT7 expression ( Figure 6B ; r = 0.3366; P < 0.01).…”

Section: Resultsmentioning

confidence: 83%

“… 14 MiR-1306-5p regulates numerous biological processes under multiple diseases pathologies. 10 , 15 , 16 For instance, Zheng et al revealed that miR-1306-5p regulates proliferation, migration and invasion of vascular smooth muscle cells by targeting lncRNA SNHG7-003. 10 Elsewhere, Genis et al found that the expression of miR-1306-5p was strongly associated with prognosis of patients with cardiovascular complications.…”

Section: Discussionmentioning

confidence: 99%

“… 10 , 15 , 16 For instance, Zheng et al revealed that miR-1306-5p regulates proliferation, migration and invasion of vascular smooth muscle cells by targeting lncRNA SNHG7-003. 10 Elsewhere, Genis et al found that the expression of miR-1306-5p was strongly associated with prognosis of patients with cardiovascular complications. 17 However, the role of miR-1306-5p in cancer tissues is not well understood.…”

Section: Discussionmentioning

confidence: 99%

Section: Mir-1306-5p Suppress the Progression Of Os Cells And Expression Of Sirt7mentioning

confidence: 97%

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lncRNA AC007207.2 Promotes Malignant Properties of Osteosarcoma via the miR-1306-5p/SIRT7 Axis

Dang

Zhou

et al. 2021

CMAR

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Background Long non-coding RNAs (lncRNAs) have been implicated in initiation and development of numerous cancers. In the present study, we explored the role of lncRNAs AC007207.2 in osteosarcoma (OS). Methods Gene expression data of OS tissues was downloaded from the TARGET database. All the experiments were repeated at least three times. Data were analyzed using Perl, R, SPSS v12.0 and GraphPad Prism 8 software. Results We found lncRNA AC007207.2 was over-expressed in OS tissues and cell lines, and this phenomenon was associated with the worse prognosis of OS. Moreover, we found that AC007207.2 promotes proliferation and metastasis of OS cells via the miR-1306-5p/SIRT7 axis. Meanwhile, we found miR-1306-5p remarkably inhibits the malignant behavior of OS cells. Conclusion lncRNA AC007207.2 promotes progression of OS by upregulating SIRT7 expression through miR-1306-5p sponging. Thus, lncRNA AC007207.2/miR-1306-5p/SIRT7 axis is a promising therapeutic target for OS treatment.

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Section: Resultsmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Mir-1306-5p Suppress the Progression Of Os Cells And Expression Of Sirt7mentioning

confidence: 97%

See 2 more Smart Citations

lncRNA AC007207.2 Promotes Malignant Properties of Osteosarcoma via the miR-1306-5p/SIRT7 Axis

Dang

Zhou

et al. 2021

CMAR

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“…Sun et al claimed that inhibition of lncRNA H19 reduced VSMC proliferation and increased apoptosis, which helped slow down atherosclerosis (Sun et al, 2020). Zheng et al found that overexpression of SNHG7 targeted and inhibited miR-1306-5p/Sirtuin7, reducing excessive proliferation, migration and invasion of VSMCs induced by oxidized low-density lipoprotein and alleviating atherosclerosis (Zheng et al, 2021). Some scholars have also stated that LINC00961 is a potential target for the treatment of atherosclerosis.…”

Section: Discussionmentioning

confidence: 99%

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SIRT7 in the aging process

Lagunas‐Rangel

2022

Cell. Mol. Life Sci.

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Aging is the result of the accumulation of a wide variety of molecular and cellular damage over time. This has been associated with a number of features termed hallmarks of aging, including genomic instability, loss of proteostasis, telomere attrition, dysregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and impaired intercellular communication. On the other hand, sirtuins are enzymes with an important role in aging and life extension, of which humans have seven paralogs (SIRT1 to SIRT7). SIRT7 is the least studied sirtuin to date, but it has been reported to serve important functions, such as promoting ribosomal RNA expression, aiding in DNA damage repair, and regulating chromatin compaction. Several studies have established a close relationship between SIRT7 and age-related processes, but knowledge in this area is still scarce. Therefore, the purpose of this review was to analyze how SIRT7 is associated with each of the hallmarks of aging, as well as with some of age-associated diseases, such as cardiovascular diseases, obesity, osteoporosis, and cancer.

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lncRNA‑SNHG7‑003 inhibits the proliferation, migration and invasion of vascular smooth muscle cells by targeting the miR‑1306‑5p/SIRT7 signaling pathway

Cited by 28 publications

References 0 publications

lncRNA AC007207.2 Promotes Malignant Properties of Osteosarcoma via the miR-1306-5p/SIRT7 Axis

lncRNA AC007207.2 Promotes Malignant Properties of Osteosarcoma via the miR-1306-5p/SIRT7 Axis

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SIRT7 in the aging process

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