lncRNA AC007207.2 Promotes Malignant Properties of Osteosarcoma via the miR-1306-5p/SIRT7 Axis

Dang, Youting; Zhou, Yue; Ou, Xuehai; Wang, Qiang; Wei, Dengke; Xie, Fei

doi:10.2147/cmar.s318975

Cited by 8 publications

(4 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…miR-1306-5p was found to decrease cerebral ischemia/reperfusion injury in vitro by targeting BIK [ 16 ]. It was also confirmed to regulate ameloblast differentiation by regulating genes related to amelogenesis imperfecta [ 15 ] and inhibit the malignant behavior of osteosarcoma cells [ 32 ]. However, the specific biological roles of miR-1306-5p and its indirect interactions and regulation of m6A in AML remain poorly understood.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA-1306-5p Regulates the METTL14-Guided m6A Methylation to Repress Acute Myeloid Leukemia

Wang

et al. 2022

Computational and Mathematical Methods in Medicine

View full text Add to dashboard Cite

miRNA and m6A methylation are two key regulators in cancers. However, in acute myeloid leukemia (AML), the relationship of miRNA and m6A methylation remains unclear. The present work is aimed at determining the effect of m6A methylation induced by miRNAs on AML and its underlying mechanism. The expression of METTL14 was detected by qRT-PCR and western blot. The growth of HL-60 cells was analyzed by CCK-8, Transwell assay, and flow cytometry. Tumor-bearing mice were established, and Ki-67 staining assay was used to detect the proliferation in vivo. Dual luciferase reporter system detected the effect of miR-1306-5p on METTL14 luciferase activity. Dot blot analysis detected m6A methylation. We found that METTL14 was upregulated in AML patients and overexpressed METTL14 promoted AML development. Further analysis indicated that METTL14 was directly targeted by miR-1306-5p and overexpressed miR-1306-5p alleviated AML progression. In addition, m6A methylation level regulated by METTL14 could be affected by miR-1306-5p. In conclusion, we found that suppressed miR-1306-5p enhanced AML progression by elevating m6A methylation level via upregulating METTL14. These findings provided basis for the development of new strategies for treating AML.

show abstract

Section: Discussionmentioning

confidence: 99%

MicroRNA-1306-5p Regulates the METTL14-Guided m6A Methylation to Repress Acute Myeloid Leukemia

Wang

et al. 2022

Computational and Mathematical Methods in Medicine

View full text Add to dashboard Cite

show abstract

“…Wang et al uncovered that sponging miR-1306-5p could stimulate the malignant behaviors of melanoma cells . MiR-1306-5p has also been reported to remarkably inhibits the malignant behavior of osteosarcoma cells . Thus, miR-1306-5p may play multiple roles and even contradictory roles in regulating malignant behaviors via different mechanisms.…”

Section: Discussionmentioning

confidence: 99%

“… 52 MiR-1306-5p has also been reported to remarkably inhibits the malignant behavior of osteosarcoma cells. 53 Thus, miR-1306-5p may play multiple roles and even contradictory roles in regulating malignant behaviors via different mechanisms. However, there was no previous literature elucidating the role of miR-1306-5p in HCC progression.…”

Section: Discussionmentioning

confidence: 99%

Construction of a Novel Cuproptosis-Related ceRNA Network-SNHG3/miR-1306-5p/PDHA1 and Identification of SNHG3 as a Prognostic Biomarker in Hepatocellular Carcinoma

Pan,

Zhang,

et al. 2023

ACS Omega

View full text Add to dashboard Cite

The crucial role of competitive endogenous RNA (ceRNA) in the malignant biological behavior of tumors has been certificated. Nevertheless, the detailed function and molecular mechanism of ceRNA associated with cuproptosis in hepatocellular carcinoma (HCC) remains dismal. In this study, we first constructed a protein–protein interaction network and identified the module with the highest degree of aggregation degree. DLAT and PDHA1 were screened out of the module after differential expression and survival analysis. Next, we reverse-predicted the upstream miRNA and lncRNA from mRNA (DLAT, PDHA1) and successfully established the ceRNA network-SNHG3/miR-1306-5p/PDHA1. SNHG3 was identified to be an independent prognostic biomarker based on the outcome of univariate and multivariate Cox analyses. Subsequently, we implemented methylation, immune infiltration, and drug sensitivity analysis to investigate the potential biological functions of SNHG3 in HCC. In addition, SNHG3 expression was upregulated in liver cancer cell lines. In vitro functional assay revealed that SNHG3 knockdown significantly attenuated proliferation, migration, and invasion of liver cancer cells. In summary, SNHG3 exhibited oncogenic characterization via sponging miR-1306-5p to regulate PDHA1, which might function as a promising prognostic indicator and a potential therapeutic target for HCC and shed new light on the molecular mechanism of HCC progression.

show abstract

“…Massive studies have identified that miRNAs such as miRNA-125a-5p, miRNA-125b, miRNA-152-3p, and miRNA-770 serve as upstream regulators of SIRT7 by targeting its 3′ UTR [135][136][137]. Besides, lncRNA AC007207.2 drove the upregulation of SIRT7 by sponging miRNA-1306-5p in osteosarcoma cells [138], while lincRNA p21 elevated SIRT7 levels by sponging miRNA-17-5p in vascular smooth muscle cells. SIRT7 expression was regulated by circRNA ZNF609 and circRNA PVT1 via miRNA-138-5p [139] and miRNA-125b/miRNA-200a sponging [140], respectively.…”

Section: Sirt7mentioning

confidence: 99%

Sirtuins at the Crossroads between Mitochondrial Quality Control and Neurodegenerative Diseases: Structure, Regulation, Modifications, and Modulators

Xu¹,

Liu²,

Li³

et al. 2023

Aging and disease

View full text Add to dashboard Cite

Sirtuins (SIRT1-SIRT7), a family of nicotinamide adenine dinucleotide (NAD + )-dependent enzymes, are key regulators of life span and metabolism. In addition to acting as deacetylates, some sirtuins have the properties of deacylase, decrotonylase, adenosine diphosphate (ADP)-ribosyltransferase, lipoamidase, desuccinylase, demalonylase, deglutarylase, and demyristolyase. Mitochondrial dysfunction occurs early on and acts causally in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease (HD). Sirtuins are implicated in the regulation of mitochondrial quality control, which is highly associated with the pathogenesis of neurodegenerative diseases. There is growing evidence indicating that sirtuins are promising and well-documented molecular targets for the treatment of mitochondrial dysfunction and neurodegenerative disorders by regulating mitochondrial quality control, including mitochondrial biogenesis, mitophagy, mitochondrial fission/fusion dynamics, and mitochondrial unfolded protein responses (mtUPR). Therefore, elucidation of the molecular etiology of sirtuinmediated mitochondrial quality control points to new prospects for the treatment of neurodegenerative diseases. However, the mechanisms underlying sirtuin-mediated mitochondrial quality control remain obscure. In this review, we update and summarize the current understanding of the structure, function, and regulation of sirtuins with an emphasis on the cumulative and putative effects of sirtuins on mitochondrial biology and neurodegenerative diseases, particularly their roles in mitochondrial quality control. In addition, we outline the potential therapeutic applications for neurodegenerative diseases of targeting sirtuin-mediated mitochondrial quality control through exercise training, calorie restriction, and sirtuin modulators in neurodegenerative diseases.

show abstract

lncRNA AC007207.2 Promotes Malignant Properties of Osteosarcoma via the miR-1306-5p/SIRT7 Axis

Cited by 8 publications

References 24 publications

MicroRNA-1306-5p Regulates the METTL14-Guided m6A Methylation to Repress Acute Myeloid Leukemia

MicroRNA-1306-5p Regulates the METTL14-Guided m6A Methylation to Repress Acute Myeloid Leukemia

Construction of a Novel Cuproptosis-Related ceRNA Network-SNHG3/miR-1306-5p/PDHA1 and Identification of SNHG3 as a Prognostic Biomarker in Hepatocellular Carcinoma

Sirtuins at the Crossroads between Mitochondrial Quality Control and Neurodegenerative Diseases: Structure, Regulation, Modifications, and Modulators

Contact Info

Product

Resources

About