LncRNA SNHG6 inhibits cell proliferation and metastasis by targeting ETS1 via the PI3K/AKT/mTOR pathway in colorectal cancer

Abstract

The term 'long non-coding rnas' (lncrnas) refers to all non-protein coding transcripts >200 nucleotides in length. Dysregulation of lncRNAs has been identified in colorectal cancer, which is one of the more serious types of cancer worldwide, third place in the mortality rates, and is associated with poor prognoses. novel evidence suggests that lncrnas serve an important role in regulating the development and progression of colorectal cancer. in the present study, it was demonstrated that SnHG6 expression was downregulated in colorectal cancer tissues by reverse transcription quantitative polymerase chain reaction assays; however, eTS1 expression levels were upregulated. overexpression of SnHG6 not only inhibited the proliferation of colon cancer cells in vitro by inducing apoptosis, but also inhibited cell proliferation, invasion and migration. The overexpression of SnHG6 inhibited colon cell viability and proliferation by targeting eTS1 through the phosphoinositide 3-kinase/protein kinase B/mechanistic target of rapamycin signaling pathway. These results suggested that SnHG6 may directly suppress eTS1, which may be one of potential mechanisms through which it inhibits the viability and proliferation of colorectal cancer cells, and it provides novel insight into the carcinogenesis of colorectal cancer. in addition, it may assist in the development of a treatment approach for eTS1-activated colorectal cancer.

Long non‐coding RNA SNHG6 promotes the growth and invasion of non‐small cell lung cancer by downregulating miR‐101‐3p

“…However, the prognostic significance of SNHG6 in patients with NSCLC is unclear. Consistent with a previous study, we found that SNHG6 expression was increased and associated with poor prognosis, pathological stage and lymph node infiltration, acting as an independent prognostic factor of tumor recurrence in patients with NSCLC.…”

“…Previous studies have showed that SNHG6 can act as an oncogenic factor or a tumor suppressor in cancers . On the one hand, SNHG6 facilitates tumor cell progression by activating JNK or TGF‐β/Smad signaling, 8,10 and on the other it suppresses cell proliferation and metastasis by inactivation of the PI3K/AKT/mTOR signaling in CRC . In the present study, consistent with a previous report, we found that knockdown of SNHG6 suppressed cell proliferation and invasion in vitro and in vivo, but overexpressing SNHG6 reversed these effects.…”

“…Multiple studies have indicated that upregulation of SNHG6 is associated with poor prognosis, lymph node metastasis and TNM stage in patients with ESCC, CRC and HCC, but its expression has been shown to be downregulated in CRC . SNHG6 is also upregulated in lung adenocarcinoma (LUAD) and positively associated with TNM stage and tumor size in LUAD patients .…”

“…Previous studies have showed that SNHG6 can act as an oncogenic factor or a tumor suppressor in cancers . On the one hand, SNHG6 facilitates tumor cell progression by activating JNK or TGF‐β/Smad signaling, 8,10 and on the other it suppresses cell proliferation and metastasis by inactivation of the PI3K/AKT/mTOR signaling in CRC .…”

Transcriptional Profiles of Long Non-coding RNA and mRNA in Sheep Mammary Gland During Lactation Period

“…For example, Yoon et al (2012) found that lincRNA p21 can directly inhibit the translation of Jun B and CTNNB1. lncRNA SNHG6 can regulate cell proliferation by participating in the translation and splicing of microRNAs (miRNAs) in cancer (Meng et al, 2019).…”