LncRNA NONMMUT055714 acts as the sponge of microRNA-7684-5p to protect against postoperative cognitive dysfunction

Wei, Changwei; Sun, Yi; Wang, Jing; Lin, Dandan; Cui, Victoria; Shi, Hui; Wu, Anshi

doi:10.18632/aging.202932

Cited by 14 publications

(11 citation statements)

References 34 publications

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“… Luo et al (2015) demonstrated that downregulation of miR-let-7d can lead to isoflurane-induced impairment of learning and memory by directly up-regulating its target amyloid precursor protein, thereby increasing Aβ production. In addition, Wei et al (2021a) also indicated that lnc NONMMUT055714 downregulation is associated with increased Aβ and p-tau expression via competing endogenous RNA (ceRNA)-mediated regulation of miR-7684-5p expression in isoflurane/orthopedic surgery-induced POCD model.…”

Section: Postoperative Cognitive Dysfunctionmentioning

confidence: 98%

“…These authors further reported that the upregulation of lncENSMUST00000136025, one of the dysregulated lncRNA types, most likely resulted in the overexpression of Bcl-211 , which promoted mitochondrial-mediated apoptosis ( Chen et al, 2016 ). Subsequently, other lncRNA types, such as NONMMUT055714 ( Wei et al, 2021a ), Rian ( Yu et al, 2021 ), and LRCF ( Zeng et al, 2021 ), have been indicated to be implicated in anesthesia-mediated neuroapoptosis.…”

Section: Postoperative Cognitive Dysfunctionmentioning

confidence: 99%

“…In addition, three lncRNA types have been identified as differentially expressed molecules and have been associated with a range of pathological processes such as mitochondrial dysfunction, oxidative stress, aging-related metabolic alterations, DNA damage, and apoptosis, as well as neurodegenerative features during sevoflurane anesthesia ( Qu et al, 2020 ). Furthermore, in a POCD mouse model, other lncRNA types, such as NONMMUT0557143, regulated the expression of oxidative stress-related markers ( Wei et al, 2021a ), such as malondialdehyde.…”

Section: Postoperative Cognitive Dysfunctionmentioning

confidence: 99%

“…Recently, accumulating proofs have emphasized a remarkable role for non-coding RNAs (ncRNAs) in the pathophysiology of POCD ( Wang et al, 2021a ; Wei et al, 2021a ; Mao et al, 2022 ). ncRNAs are a set of RNA sequences that cannot be translated into proteins.…”

Section: Introductionmentioning

confidence: 99%

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Recent progress on the role of non-coding RNA in postoperative cognitive dysfunction

Yang

Chen

et al. 2022

Front. Cell. Neurosci.

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Postoperative cognitive dysfunction (POCD), especially in elderly patients, is a serious complication characterized by impairment of cognitive and sensory modalities after surgery. The pathogenesis of POCD mainly includes neuroinflammation, neuronal apoptosis, oxidative stress, accumulation of Aβ, and tau hyperphosphorylation; however, the exact mechanism remains unclear. Non-coding RNA (ncRNA) may play an important role in POCD. Some evidence suggests that microRNA, long ncRNA, and circular RNA can regulate POCD-related processes, making them promising biomarkers in POCD diagnosis, treatment, and prognosis. This article reviews the crosstalk between ncRNAs and POCD, and systematically discusses the role of ncRNAs in the pathogenesis and diagnosis of POCD. Additionally, we explored the possible mechanisms of ncRNA-associated POCD, providing new knowledge for developing ncRNA-based treatments for POCD.

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Section: Postoperative Cognitive Dysfunctionmentioning

confidence: 98%

Section: Postoperative Cognitive Dysfunctionmentioning

confidence: 99%

Section: Postoperative Cognitive Dysfunctionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Recent progress on the role of non-coding RNA in postoperative cognitive dysfunction

Yang

Chen

et al. 2022

Front. Cell. Neurosci.

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“…lncRNA-ES3 suppresses miR-34c-5p expression through direct interaction, and knockdown of this lncRNA inhibits the senescence of vascular smooth muscle cells, regulated through the lncRNA-ES3/miR-34c-5p/Bcl-2 modifying factor axis [ 39 ]. The lncRNA NONMMUT 055,714 constitutes a miRNA-7684-5p sponge that protects against postoperative cognitive dysfunction [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

Identification of a hippocampal lncRNA-regulating network in a natural aging rat model

Liu

et al. 2022

BMC Neurosci

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Background Dysregulation of long noncoding RNA (lncRNA) expression is related to aging and age-associated neurodegenerative diseases, and the lncRNA expression profile in the aging hippocampus is not well characterized. In the present investigation, the changed mRNAs and lncRNAs were confirmed via deep RNA sequencing. GO and KEGG pathway analyses were conducted to investigate the principal roles of the clearly dysregulated mRNAs and lncRNAs. Subsequently, through the prediction of miRNAs via which mRNAs and lncRNAs bind together, a competitive endogenous RNA network was constructed. Results A total of 447 lncRNAs and 182 mRNAs were upregulated, and 385 lncRNAs and 144 mRNAs were downregulated. Real-time reverse transcription-polymerase chain reaction validated the reliability of mRNA and lncRNA sequencing. KEGG pathway and GO analyses revealed that differentially expressed (DE) mRNAs were associated with cell adhesion molecules (CAMs), the p53 signaling pathway (SP), phagosomes, PPAR SP and ECM—receptor interactions. KEGG pathway and GO analyses showed that the target genes of the DE lncRNAs were related to cellular senescence, the p53 signaling pathway, leukocyte transendothelial migration and tyrosine metabolism. Coexpression analyses showed that 561 DE lncRNAs were associated with DE mRNAs. A total of 58 lncRNA–miRNA–mRNA target pairs were confirmed in this lncRNA‒miRNA‒mRNA network, comprising 10 mRNAs, 13 miRNAs and 38 lncRNAs. Conclusions We found specific lncRNAs and mRNAs in the hippocampus of natural aging model rats, as well as abnormal regulatory ceRNA networks. Our outcomes help explain the pathogenesis of brain aging and provide direction for further research.

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Research Progress on Exosomes and MicroRNAs in the Microenvironment of Postoperative Neurocognitive Disorders

Huang

Zhou

et al. 2022

Neurochem Res

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LncRNA NONMMUT055714 acts as the sponge of microRNA-7684-5p to protect against postoperative cognitive dysfunction

Cited by 14 publications

References 34 publications

Recent progress on the role of non-coding RNA in postoperative cognitive dysfunction

Recent progress on the role of non-coding RNA in postoperative cognitive dysfunction

Identification of a hippocampal lncRNA-regulating network in a natural aging rat model

Research Progress on Exosomes and MicroRNAs in the Microenvironment of Postoperative Neurocognitive Disorders

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