Recent progress on the role of non-coding RNA in postoperative cognitive dysfunction

Yang, Yu-Shen; He, Shi-Ling; Chen, Wei-can; Wang, Cong-Mei; Huang, Qiaomei; Shi, Yan‐Chuan; Lin, Shu; He, Hefan

doi:10.3389/fncel.2022.1024475

Cited by 5 publications

(3 citation statements)

References 123 publications

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“…This provides additional targets and potential molecular interactions for further preclinical research on POCD. Bioinformatics analysis of DEGs and TUNEL assay revealed an increase of neuronal apoptosis in the hippocampus of POCD mice, which aligns with previous studies [ 25 , 26 ]. We discovered that circAKT3 was downregulated in the hippocampal neurons of POCD mice.…”

Section: Discussionsupporting

confidence: 91%

CircAKT3 alleviates postoperative cognitive dysfunction by stabilizing the feedback cycle of miR-106a-5p/HDAC4/MEF2C axis in hippocampi of aged mice

Wang,

Tang,

Zhu

et al. 2024

Cell. Mol. Life Sci.

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Circular RNAs (circRNAs) have garnered significant attention in the field of neurodegenerative diseases including Alzheimer’s diseases due to their covalently closed loop structure. However, the involvement of circRNAs in postoperative cognitive dysfunction (POCD) is still largely unexplored. To identify the genes differentially expressed between non-POCD (NPOCD) and POCD mice, we conducted the whole transcriptome sequencing initially in this study. According to the expression profiles, we observed that circAKT3 was associated with hippocampal neuronal apoptosis in POCD mice. Moreover, we found that circAKT3 overexpression reduced apoptosis of hippocampal neurons and alleviated POCD. Subsequently, through bioinformatics analysis, our data showed that circAKT3 overexpression in vitro and in vivo elevated the abundance of miR-106a-5p significantly, resulting in a decrease of HDAC4 protein and an increase of MEF2C protein. Additionally, this effect of circAKT3 was blocked by miR-106a-5p inhibitor. Interestingly, MEF2C could activate the transcription of miR-106a-5p promoter and form a positive feedback loop. Therefore, our findings revealed more potential modulation ways between circRNA-miRNA and miRNA-mRNA, providing different directions and targets for preclinical studies of POCD.

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Section: Discussionsupporting

confidence: 91%

CircAKT3 alleviates postoperative cognitive dysfunction by stabilizing the feedback cycle of miR-106a-5p/HDAC4/MEF2C axis in hippocampi of aged mice

Wang,

Tang,

Zhu

et al. 2024

Cell. Mol. Life Sci.

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“…CircRNA may also play important role in maintaining BBB integrity. Recently, Yang et al (2022b) ; Yang et al (2022c) found that circ-FoxO3 can inhibit the mTORC1 pathway during ischemia/reperfusion and then regulate autophagy to protect BBB. Collectively, the specific molecular mechanism of non-coding RNA mediating the prevention and treatment of POCD is still worth exploring in depth.…”

Section: Potential Pathophysiological Processes and Mechanismsmentioning

confidence: 99%

Research progress on perioperative blood-brain barrier damage and its potential mechanism

Qiu

et al. 2023

Front. Cell Dev. Biol.

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The blood-brain barrier (BBB) is an important barrier separating the central nervous system from the periphery. The composition includes endothelial cells, pericytes, astrocytes, synapses and tight junction proteins. During the perioperative period, anesthesia and surgical operations are also a kind of stress to the body, which may be accompanied by blood-brain barrier damage and brain metabolism dysfunction. Perioperative blood-brain barrier destruction is closely associated with cognitive impairment and may increase the risk of postoperative mortality, which is not conducive to enhanced recovery after surgery. However, the potential pathophysiological process and specific mechanism of blood-brain barrier damage during the perioperative period have not been fully elucidated. Changes in blood-brain barrier permeability, inflammation and neuroinflammation, oxidative stress, ferroptosis, and intestinal dysbiosis may be involved in blood-brain barrier damage. We aim to review the research progress of perioperative blood-brain barrier damage and its potential adverse effects and potential molecular mechanisms, and provide ideas for the study of homeostasis maintenance of brain function and precision anesthesia.

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“…Most studies investigate the changes of a specific ncRNA and its target gene expression in POCD animal models. See Yazit et al [ 348 ] and Yang et al [ 349 ] for recent comprehensive reviews of ncRNAs in PND.…”

Section: Pathogenesis Of Pndmentioning

confidence: 99%

Intergenerational Perioperative Neurocognitive Disorder

Morey

Seubert

et al. 2023

Biology

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Accelerated neurocognitive decline after general anesthesia/surgery, also known as perioperative neurocognitive disorder (PND), is a widely recognized public health problem that may affect millions of patients each year. Advanced age, with its increasing prevalence of heightened stress, inflammation, and neurodegenerative alterations, is a consistent contributing factor to the development of PND. Although a strong homeostatic reserve in young adults makes them more resilient to PND, animal data suggest that young adults with pathophysiological conditions characterized by excessive stress and inflammation may be vulnerable to PND, and this altered phenotype may be passed to future offspring (intergenerational PND). The purpose of this narrative review of data in the literature and the authors’ own experimental findings in rodents is to draw attention to the possibility of intergenerational PND, a new phenomenon which, if confirmed in humans, may unravel a big new population that may be affected by parental PND. In particular, we discuss the roles of stress, inflammation, and epigenetic alterations in the development of PND. We also discuss experimental findings that demonstrate the effects of surgery, traumatic brain injury, and the general anesthetic sevoflurane that interact to induce persistent dysregulation of the stress response system, inflammation markers, and behavior in young adult male rats and in their future offspring who have neither trauma nor anesthetic exposure (i.e., an animal model of intergenerational PND).

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Recent progress on the role of non-coding RNA in postoperative cognitive dysfunction

Cited by 5 publications

References 123 publications

CircAKT3 alleviates postoperative cognitive dysfunction by stabilizing the feedback cycle of miR-106a-5p/HDAC4/MEF2C axis in hippocampi of aged mice

CircAKT3 alleviates postoperative cognitive dysfunction by stabilizing the feedback cycle of miR-106a-5p/HDAC4/MEF2C axis in hippocampi of aged mice

Research progress on perioperative blood-brain barrier damage and its potential mechanism

Intergenerational Perioperative Neurocognitive Disorder

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