LncRNA MYLK-AS1 facilitates tumor progression and angiogenesis by targeting miR-424-5p/E2F7 axis and activating VEGFR-2 signaling pathway in hepatocellular carcinoma

Teng, Fei; Zhang, Juxiang; Chang, Qimeng; Wu, Xubo; Tang, Wei‐Guo; Wang, Jianfa; Feng, Jin-Feng; Zhang, Ziping; Hu, Zhiqiu

doi:10.1186/s13046-020-01739-z

Cited by 91 publications

(64 citation statements)

References 40 publications

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“… 15 , 16 For instance, lncRNA MYLK-AS1 facilitated HCC progression and angiogenesis by targeting miR-424-5p/E2F7 axis and activating VEGFR-2 signaling pathway. 17 lncRNA CASC9 promoted bladder cancer proliferation and epithelial-mesenchymal transition by sponging miR-758-3p and upregulating TGF-β2. 18 Therefore, it was predicted that miR-671-5p may be a direct target of LINC00908.…”

Section: Discussionmentioning

confidence: 99%

LINC00908 Promotes Diffuse Large B-Cell Lymphoma Development by Down-Regulating miR-671-5p

Zeng¹,

Wei²,

Wei³

et al. 2021

CMAR

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Introduction Emerging evidence has revealed that long noncoding RNA (lncRNA) play important role in almost all kinds of human cancers. LINC00908 has been reported to be involved in the development of prostate cancer, colorectal cancer and gastric cancer which was functioned as an oncogene. However, the potential biology role and molecular mechanism of LINC00908 in diffuse large B-cell lymphoma are still unclear. Methods LINC00908 and miR-671-5p expression were evaluated in DLBCL tissues and cell lines using RT-qPCR. CCK-8 and transwell assay were used to analyze the in vitro role of LINC00908 in DLBCL progression. The xenograft model was used to explore the in vivo role of LINC00908 in DLBCL growth. The physical interaction between LINC00908 and miR-671-5p was confirmed using bioinformatics analysis and a dual luciferase assay, RIP and RNA pull down. Results The expression of LINC00908 was markedly up-regulated in diffuse large B-cell lymphoma tissues and cell lines, and the decreased expression of LINC00908 significantly inhibited diffuse large B-cell lymphoma cell proliferation and invasion. Then, we revealed that LINC00908 directly interacted with miR-671-5p, which was down-regulated in diffuse large B-cell lymphoma cells and highly expressed with LINC00908 knockdown. Moreover, luciferase reporter assays and RNA immunoprecipitation (RIP) assay further proved that miR-671-5p is a direct target of LINC00908 in diffuse large B-cell lymphoma cells. Rescue experiments were also performed, and we confirmed that LINC00908 acts as an oncogene role in diffuse large B-cell lymphoma through miR-671-5p. Finally, the influence of LINC00908 silence significantly inhibited diffuse large B-cell lymphoma growth in vivo. Conclusion LINC00908 promotes malignancy of diffuse large B-cell lymphoma through regulating miR-671-5p.

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Section: Discussionmentioning

confidence: 99%

LINC00908 Promotes Diffuse Large B-Cell Lymphoma Development by Down-Regulating miR-671-5p

Zeng¹,

Wei²,

Wei³

et al. 2021

CMAR

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“…HCC is the fifth-most common cancer, with the second-highest mortality rate worldwide. 50 , 51 , 52 The incidences of liver cancer and mortality have been increasing in the past few years, particularly in Asia. Traditional surgery is no longer the preferred treatment for HCC, so new therapeutic directions need to be explored.…”

Section: Discussionmentioning

confidence: 99%

Construction of a Myc-associated ceRNA network reveals a prognostic signature in hepatocellular carcinoma

Zhang

Shi

Liu

et al. 2021

Molecular Therapy - Nucleic Acids

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Hepatocellular carcinoma (HCC) remains an extremely lethal disease worldwide. High-throughput methods have revealed global transcriptome dysregulation; however, a comprehensive investigation of the complexity and behavioral characteristics of the competing endogenous RNA (ceRNA) network in HCC is lacking. In this study, we extracted the transcriptome (RNA) sequencing data of 371 HCC patients from The Cancer Genome Atlas platform. With the comparison of the high Myc expression (Myc high ) tumor and low Myc expression (Myc low ) tumor groups in HCC, we identified 1,125 differentially expressed (DE) mRNAs, 589 long non-coding RNAs (lncRNAs), and 93 microRNAs (miRNAs). DE RNAs predicted the interactions necessary to construct an associated Myc ceRNA network, including 19 DE lncRNAs, 5 miRNAs, and 72 mRNAs. We identified a significant signature (long intergenic non-protein-coding [LINC] RNA 2691 [LINC02691] and LINC02499) that effectively predicted overall survival and had protective effects. The target genes of microRNA (miR)-212-3p predicted to intersect with DE mRNAs included SEC14-like protein 2 (SEC14L2) and solute carrier family 6 member 1 (SLC6A1), which were strongly correlated with survival and prognosis. With the use of the lncRNA-miRNA-mRNA axis, we constructed a ceRNA network containing four lncRNAs (LINC02691, LINC02499, LINC01354, and NAV2 antisense RNA 4), one miRNA (miR-212-3p), and two mRNAs (SEC14L2 and SLC6A1). Overall, we successfully constructed a mutually regulated ceRNA network and identified potential precision-targeted therapies and prognostic biomarkers.

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“…Factors including hypoxic conditions, ROS production, and secretion of growth factors and cytokines greatly contribute to the upregulation of VEGF. Not surprisingly, some lncRNAs such as UBE2CP3 and MYLK-AS1 have been shown to modulate the process of angiogenesis through activating the VEGF signaling pathway [ 37 , 38 ]. Furthermore, lncRNA MVIH, whose expression level predicts poor outcome in HCC patients, activates tumor-inducing angiogenesis by inhibiting the secretion of a glycolytic enzyme phosphoglycerate kinase (PGK1) [ 39 ].…”

Section: Roles Of Oncogenic and Tumor-suppressive Lncrnas In Hccmentioning

confidence: 99%

Decoding the Roles of Long Noncoding RNAs in Hepatocellular Carcinoma

Wong

2021

IJMS

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Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies worldwide. HCC is associated with several etiological factors, including HBV/HCV infections, cirrhosis, and fatty liver diseases. However, the molecular mechanism underlying HCC development remains largely elusive. The advent of high-throughput sequencing has unveiled an unprecedented discovery of a plethora of long noncoding RNAs (lncRNAs). Despite the lack of coding capacity, lncRNAs have key roles in gene regulation through interacting with various biomolecules. It is increasingly evident that the dysregulation of lncRNAs is inextricably linked to HCC cancer phenotypes, suggesting that lncRNAs are potential prognostic markers and therapeutic targets. In light of the emerging research in the study of the regulatory roles of lncRNAs in HCC, we discuss the association of lncRNAs with HCC. We link the biological processes influenced by lncRNAs to cancer hallmarks in HCC and describe the associated functional mechanisms. This review sheds light on future research directions, including the potential therapeutic applications of lncRNAs.

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LncRNA MYLK-AS1 facilitates tumor progression and angiogenesis by targeting miR-424-5p/E2F7 axis and activating VEGFR-2 signaling pathway in hepatocellular carcinoma

Cited by 91 publications

References 40 publications

LINC00908 Promotes Diffuse Large B-Cell Lymphoma Development by Down-Regulating miR-671-5p

LINC00908 Promotes Diffuse Large B-Cell Lymphoma Development by Down-Regulating miR-671-5p

Construction of a Myc-associated ceRNA network reveals a prognostic signature in hepatocellular carcinoma

Decoding the Roles of Long Noncoding RNAs in Hepatocellular Carcinoma

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