LncRNA MALAT1 aggravates the retinal angiogenesis via miR-320a/HIF-1α axis in diabetic retinopathy

Chen, Zhe; Yang, Jingying; Gao, Yang; Jiang, Shanshan; Li, Zuyou; Wang, Yao; Hu, Zhongyin; Han, Fang; Ni, Ninghua

doi:10.1016/j.exer.2022.108984

Cited by 10 publications

(8 citation statements)

References 34 publications

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“… [ 64 – 67 ] HOTTIP Increased in STZ-induced DR mice and rats Contribute to diabetes-induced visual function decline and retinal inflammation Activates p38/MAPK pathway, and promotes angiogenesis by interacting with WDR5 and MLL, which regulates ICAM-1 and VEGF transcription [ 70 , 139 – 141 ] IPW Upregulated in hypoxic ECs and the choroid of laser induced CNV in mice Promote choroidal sprouting angiogenesis and laser-induced CNV Represses miR-370 at the DLK1-DIO3 locus, which targets KDR and BMP-2 [ 82 ] lncEGFL7OS Enhances human angiogenesis Interacts with MAX protein via to regulate EGFL7/miR-126 expression, therefore promoting MAPK and AKT pathway [ 134 ] MALAT1 Upregulated in HG-treated hRECs, OIR mouse model and diabetic patients Promotes retinal vascularization, and contributes to DR vascular phenotypes Acts as ceRNA for miR203a-3p, miR-205-5p, miR-124-3p, and miR-320 that target VEGF, HIF1 and EGR1, and promotes inflammation by elevating IL-1β, IL-6 and TNF-α levels. [ 39 , 48 , 85 – 91 ] MIAT Upregulated by HG in cell lines, in diabetic rats and mice and in the plasma of DR patients Contributes to diabetic-induced vascular phenotypes Acts as ceRNA for mirR-150-5p that targets VEGF [ 93 – 96 ] NEAT1 Up- or down-regulated by HG-treated retinal cells, downregulated in STZ-treated mice but upregulated in the serum of DR patients Promotes laser-induced CNV Enhances angiogenesis by acting as ceRNA for miR-19-5p that targets TGB-βR2 and therefore enhancing VEGF-A expression; Inhibits resolving inflammation by inhibiting M2 macrophage polarization by acting ceRNA for miRNA-148a-3p that targets PTEN...…”

Section: Functional Study Of Lncrnas In Ocular Angiogenesismentioning

confidence: 99%

The role of long noncoding RNAs in ocular angiogenesis and vascular oculopathy

Gandhi,

Wang,

et al. 2024

Cell Biosci

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Background Long noncoding RNAs (lncRNAs) are RNA transcripts over 200 nucleotides in length that do not code for proteins. Initially considered a genomic mystery, an increasing number of lncRNAs have been shown to have vital roles in physiological and pathological conditions by regulating gene expression through diverse mechanisms depending on their subcellular localization. Dysregulated angiogenesis is responsible for various vascular oculopathies, including diabetic retinopathy, retinopathy of prematurity, age-related macular degeneration, and corneal neovascularization. While anti-VEGF treatment is available, it is not curative, and long-term outcomes are suboptimal, and some patients are unresponsive. Results and summary To better understand these diseases, researchers have investigated the role of lncRNAs in regulating angiogenesis and models of vascular oculopathies. This review summarizes recent research on lncRNAs in ocular angiogenesis, including the pro-angiogenic lncRNAs ANRIL, HOTAIR, HOTTIP, H19, IPW, MALAT1, MIAT, NEAT1, and TUG1, the anti-angiogenic lncRNAs MEG3 and PKNY, and the human/primate specific lncRNAs lncEGFL7OS, discussing their functions and mechanisms of action in vascular oculopathies.

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Section: Functional Study Of Lncrnas In Ocular Angiogenesismentioning

confidence: 99%

The role of long noncoding RNAs in ocular angiogenesis and vascular oculopathy

Gandhi,

Wang,

et al. 2024

Cell Biosci

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“…Another research group found that Yes‐associated protein 1 (YAP1) promotes the angiogenesis of hRMECs via the MALAT1‐mediated inhibition of miR‐200b‐3p that directly targeted vascular endothelial growth factor A (VEGF‐A) (Han et al 2020a). Also, it has been disclosed that MALAT1 can aggravate retinal angiogenesis by targeting the miR‐320a/HIF‐1α axis in DR (Chen et al 2022). In addition, MALAT1 may affect angiogenesis in oxygen‐induced retinopathy mouse models by sponging miR‐203a‐3p (Yu et al 2020).…”

Section: Exploring the Functional Roles Of Lncrna Malat1 In Ocular Di...mentioning

confidence: 99%

Potential roles of lncRNA MALAT1-miRNA interactions in ocular diseases

Nasrolahi,

Khojasteh Pour,

Mousavi Salehi

et al. 2023

J. Cell Commun. Signal.

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Long non-coding RNAs (lncRNAs) are non-protein coding transcripts that are longer than 200 nucleotides in length. LncRNAs are implicated in gene expression at the transcriptional, translational, and epigenetic levels, and thereby impact different cellular processes including cell proliferation, migration, apoptosis, angiogenesis, and immune response. In recent years, numerous studies have demonstrated the significant contribution of lncRNAs to the pathogenesis and progression of various diseases, such as stroke, heart disease, and cancer. Further investigations have shown that lncRNAs have altered expression patterns in ocular tissues and cell lines during pathological conditions. The pathogenesis of various ocular diseases, including glaucoma, cataract, corneal diseases, proliferative vitreoretinopathy, diabetic retinopathy, and retinoblastoma, is influenced by the involvement of specific lncRNAs which play a critical role in the development and progression of these diseases. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a well-researched lncRNA in the context of ocular diseases, which has been shown to exert its biological effects through several signaling pathways and downstream targets. The present review provides a comprehensive summary of the molecular mechanisms underlying the biological functions and roles of MALAT1 in ocular diseases.

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“…In line with this finding, Yu and colleagues [ 45 ] demonstrated that MALAT1 , Vegfa , and Hif-1α levels were increased in DR retinal tissues of an oxygen-induced retinopathy (OIR) mouse model, whereas the expression of miR-203a-3p was decreased [ 45 ]. Interestingly, both Müller cells and human retinal microvascular endothelial cells (HRMECs) cultured in high-glucose conditions, also display the overexpression of MALAT1 and HIF-1α paralleled to the reduced expression of miR-320a [ 54 ]. The overexpression of miR-320a downregulates Hif-1α and inhibits invasion, angiogenesis, and vascular permeability of mouse retinal microvascular endothelial cells (MRMECs), suggesting that MALAT1 could inhibit HIF-1α and angiogenesis by sponging miR-320a [ 54 ].…”

Section: Long Non Coding Rnas With Increased Expression In Diabetic R...mentioning

confidence: 99%

“…Interestingly, both Müller cells and human retinal microvascular endothelial cells (HRMECs) cultured in high-glucose conditions, also display the overexpression of MALAT1 and HIF-1α paralleled to the reduced expression of miR-320a [ 54 ]. The overexpression of miR-320a downregulates Hif-1α and inhibits invasion, angiogenesis, and vascular permeability of mouse retinal microvascular endothelial cells (MRMECs), suggesting that MALAT1 could inhibit HIF-1α and angiogenesis by sponging miR-320a [ 54 ]. Accordingly, also HG-stimulated HRMECs display high expression of MALAT1 and VEGF A, as well as a reduced expression of both miR-203a-3p and miR-205-5p [ 45 , 55 ].…”

Section: Long Non Coding Rnas With Increased Expression In Diabetic R...mentioning

confidence: 99%

Diabetic Retinopathy: Are lncRNAs New Molecular Players and Targets?

et al. 2022

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The growing incidence of diabetes mellitus worldwide implies the increasing prevalence of several related macro- (e.g., hypertension and atherosclerosis) and micro-vascular (e.g., nephropathy and retinopathy) complications. Notably, diabetic retinopathy (DR) is the leading cause of blindness in older diabetic patients and can occur with different degrees of severity. Chronic hyperglycemia is the main determinant of the functional damage of retinal cells. The oxidative stress, inflammatory factors and vascular endothelial growth factor signaling have been widely reported as contributors of DR onset and progression, and an emerging role has been described for different classes of non-coding RNA, including several long non-coding RNAs (lncRNAs). Here, we report the main results of all research articles (i.e., 150) listed on PubMed database from 2014 to 2022 regarding the putative role of lncRNAs in DR, including small nucleolar RNA host genes (SNHGs). Particularly, in this review we describe all lncRNAs and SNHGs with altered expression in DR and related contexts, discussing their association with DR outcomes, their mechanism of action related to DR, the molecular/functional effects, as well as the biological and experimental contexts. Thus, herein we provide an overview of the current state of knowledge regarding the putative involvement of 50 lncRNAs and SNHGs in the pathogenesis of DR, highlighting their potential as therapeutic targets or biomarkers for improving the clinical management of DR.

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LncRNA MALAT1 aggravates the retinal angiogenesis via miR-320a/HIF-1α axis in diabetic retinopathy

Cited by 10 publications

References 34 publications

The role of long noncoding RNAs in ocular angiogenesis and vascular oculopathy

The role of long noncoding RNAs in ocular angiogenesis and vascular oculopathy

Potential roles of lncRNA MALAT1-miRNA interactions in ocular diseases

Diabetic Retinopathy: Are lncRNAs New Molecular Players and Targets?

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