LncRNA H19-elevated LIN28B promotes lung cancer progression through sequestering miR-196b

Ren, Jin; Fu, Jing; Ma, Tiangang; Yan, Bingdi; Gao, Rong; An, Zhe; Wang, Dan

doi:10.1080/15384101.2018.1482137

Cited by 43 publications

(32 citation statements)

References 46 publications

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“…By analyzing the public database, H19 was one of most overexpressed lncRNAs in primary tumor and metastatic tissues compared with adjacent normal tissues in CRC. Aberrant expression of H19 has been demonstrated in various kinds of malignancies including lung cancer, gastric cancer and pancreatic cancer [14][15][16]. Furthermore, Zhou et al reported that H19 lead to epithelial-to-mesenchymal transition (EMT), a pivotal step in cancer metastasis [17], by acting as miRNA sponges to inhibit the functions of related miRNA [18].…”

Section: Introductionmentioning

confidence: 99%

Long non-coding RNA H19 promotes colorectal cancer metastasis via binding to hnRNPA2B1

Zhang

Huang

Yuan

et al. 2020

J Exp Clin Cancer Res

103

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Background: Long non-coding RNA H19 was demonstrated to be significantly correlated with tumor metastasis. However, the specific functions of H19 in colorectal cancer (CRC) metastasis and the underlying mechanism are still largely unclear. Methods: Use public database to screen the potential lncRNA crucial for metastasis in colorectal cancer. The expression of H19 in clinical CRC specimens was detected by qRT-PCR. The effect of H19 on the metastasis of CRC cells was investigated by transwell, wound healing assays, CCK-8 assays and animal studies. The potential proteins binding to H19 were identified by LC-MS and verified by RNA immunoprecipitation (RIP). The expression of indicated RNA and proteins were measured by qRT-PCR or western blot. Results: We found the expression of lncRNA H19 was significantly upregulated in primary tumor and metastatic tissues, correlated with poor prognosis in CRC. Ectopic H19 expression promoted the metastasis of colorectal cancer cells in vitro and in vivo, and induced epithelial-to-mesenchymal transition (EMT). Mechanistically, H19 directly bound to hnRNPA2B1. Knockdown of hnRNPA2B1 attenuated the H19-induce migration and invasion in CRC cells. Furthermore, H19 stabilized and upregulated the expression of Raf-1 by facilitated the interaction between hnRNPA2B1 and Raf-1 mRNA, resulting in activation of Raf-ERK signaling. Conclusions: Our findings demonstrate the role of H19/hnRNPA2B1/EMT axis in regulation CRC metastasis, suggested H19 could be a potential biomarker to predict prognosis as well as a therapeutic strategy for CRC.

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Section: Introductionmentioning

confidence: 99%

Long non-coding RNA H19 promotes colorectal cancer metastasis via binding to hnRNPA2B1

Zhang

Huang

Yuan

et al. 2020

J Exp Clin Cancer Res

103

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“…It has been demonstrated that upregulation of H19 can induce cell proliferation, invasion, and EMT occurrence by acting as an miRNA sponge and regulating miRNA-203-mediated EMT [66]. Additionally, H19 can induce cell proliferation by promoting the expression of pro-oncogene lin-28 homolog B (LIN28B) via the inhibition of miR-196b expression in A549 and H1299 LC cell lines [71]. H19 can also compete with miR-107 to bind neurofibromin 1 (NF1), which stimulates the development of NSCLC [42,72].…”

Section: Lncrnas In Lung Cancer (Lc)mentioning

confidence: 99%

Long Non-Coding RNA in the Pathogenesis of Cancers

Chi

Wang

et al. 2019

Cells

629

452

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The incidence and mortality rate of cancer has been quickly increasing in the past decades. At present, cancer has become the leading cause of death worldwide. Most of the cancers cannot be effectively diagnosed at the early stage. Although there are multiple therapeutic treatments, including surgery, radiotherapy, chemotherapy, and targeted drugs, their effectiveness is still limited. The overall survival rate of malignant cancers is still low. It is necessary to further study the mechanisms for malignant cancers, and explore new biomarkers and targets that are more sensitive and effective for early diagnosis, treatment, and prognosis of cancers than traditional biomarkers and methods. Long non-coding RNAs (lncRNAs) are a class of RNA transcripts with a length greater than 200 nucleotides. Generally, lncRNAs are not capable of encoding proteins or peptides. LncRNAs exert diverse biological functions by regulating gene expressions and functions at transcriptional, translational, and post-translational levels. In the past decade, it has been demonstrated that the dysregulated lncRNA profile is widely involved in the pathogenesis of many diseases, including cancer, metabolic disorders, and cardiovascular diseases. In particular, lncRNAs have been revealed to play an important role in tumor growth and metastasis. Many lncRNAs have been shown to be potential biomarkers and targets for the diagnosis and treatment of cancers. This review aims to briefly discuss the latest findings regarding the roles and mechanisms of some important lncRNAs in the pathogenesis of certain malignant cancers, including lung, breast, liver, and colorectal cancers, as well as hematological malignancies and neuroblastoma.

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“…This is due to the sponging of miR-196b by H19, that normally supresses LIN28 mRNA translation. LIN28 expression allowed by H19 leads to the promotion of lung cancer cell proliferation [67]. Similarly, H19 has been found to sponge miR-3126-5p to allow the expression of ERβ receptor in papillary thyroid carcinoma, but also to sponge miR-193b in hepatocellular carcinoma, leading to the activation of MAPK1 and other oncogenes [57,68].…”

Section: H19 Contributes To the Enrichment And Maintenance Of Cscsmentioning

confidence: 90%

Propagation and Maintenance of Cancer Stem Cells: A Major Influence of the Long Non-Coding RNA H19

Lecerf

Peperstraete

Bourhis

et al. 2020

Cells

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Cancer stem cells (CSCs) represent a rare population of tumor cells that exhibit stem cell properties with the abilities of self-renewal and differentiation. These cells are now widely accepted to be responsible for tumor initiation, development, resistance to conventional therapies, and recurrence. Thus, a better understanding of the molecular mechanisms involved in the control of CSCs is essential to improve patient management in terms of diagnostics and therapies. CSCs are regulated by signals of the tumor microenvironment as well as intrinsic genetic and epigenetic modulators. H19, the first identified lncRNA is involved in the development and progression of many different cancer types. Recently, H19 has been demonstrated to be implicated in the regulation of CSCs in different types of cancers. The aim of this review is to provide an overview of the role and mechanisms of action of H19 in the regulation of CSCs. We summarize how H19 may regulate CSC division and cancer cell reprogramming, thus affecting metastasis and drug resistance. We also discuss the potential clinical implications of H19.

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LncRNA H19-elevated LIN28B promotes lung cancer progression through sequestering miR-196b

Cited by 43 publications

References 46 publications

Long non-coding RNA H19 promotes colorectal cancer metastasis via binding to hnRNPA2B1

Long non-coding RNA H19 promotes colorectal cancer metastasis via binding to hnRNPA2B1

Long Non-Coding RNA in the Pathogenesis of Cancers

Propagation and Maintenance of Cancer Stem Cells: A Major Influence of the Long Non-Coding RNA H19

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