lncRNA GAS5 inhibits malignant progression by regulating macroautophagy and forms a negative feedback regulatory loop with the miR‑34a/mTOR/SIRT1 pathway in colorectal cancer

Zhang, Haogang; Wang, Fu‐Jing; Wang, Yao; Zhao, Zi‐Xing; Qiao, Pengfei

doi:10.3892/or.2020.7825

Cited by 21 publications

(13 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Overexpression of miR-34a forms a negative feedback regulation loop through the SIRT1/mTOR/GAS5 axis, which may explain why GAS5 - mediated autophagy in CRC is in a relatively balanced state. Thus, it plays an anti-apoptotic role in cancer progression and provides a new perspective on the molecular mechanism of CRC ( 33 ).…”

Section: The Tumor Suppressor Mechanism Of Gas5 In Various Types Of C...mentioning

confidence: 99%

Research Progress of Long Non-Coding RNA GAS5 in Malignant Tumors

Lin

Gao

et al. 2022

Front. Oncol.

View full text Add to dashboard Cite

With completing the whole genome sequencing project, awareness of lncRNA further deepened. The growth arrest-specific transcript 5 (GAS5) was initially identified in growth-inhibiting cells. GAS5 is a lncRNA (long non-coding RNA), and it plays a crucial role in various human cancers. There are small ORFs (open reading frames) in the exons of the GAS5 gene sequence, but they do not encode functional proteins. In addition, GAS5 is also the host gene of several small nucleolar RNAs (snoRNA). These snoRNAs are believed to play a suppressive role during tumor progression by methylating ribosomal RNA (rRNA). As a result, GAS5 expression levels in tumor tissues are significantly reduced, leading to increased malignancy, poor prognosis, and drug resistance. Recent studies have demonstrated that GAS5 can interact with miRNAs by base-pairing and other functional proteins to inhibit their biological functions, impacting signaling pathways and changing the level of intracellular autophagy, oxidative stress, and immune cell function in vivo. In addition, GAS5 participates in regulating proliferation, invasion, and apoptosis through the above molecular mechanisms. This article reviews the recent discoveries on GAS5, including its expression levels in different tumors, its biological behavior, and its molecular regulation mechanism in human cancers. The value of GAS5 as a molecular marker in the prevention and treatment of cancers is also discussed.

show abstract

Section: The Tumor Suppressor Mechanism Of Gas5 In Various Types Of C...mentioning

confidence: 99%

Research Progress of Long Non-Coding RNA GAS5 in Malignant Tumors

Lin

Gao

et al. 2022

Front. Oncol.

View full text Add to dashboard Cite

show abstract

“…indicated the importance of the circ_0020710/miR-370-3p/CXCL12 axis in melanoma ( 41 ). Regarding the regulated proteins, SIRT1 ( 101 – 103 ), CXCL12 ( 104 – 106 ), etc., served as important regulators in the mTOR signaling pathway.…”

Section: Roles Of Circrnas In Immune-related Diseasesmentioning

confidence: 99%

Past, Present and Future: The Relationship Between Circular RNA and Immunity

Huang

et al. 2022

Front. Immunol.

View full text Add to dashboard Cite

The immune system has evolved since the birth of humans. However, immune-related diseases have not yet been overcome due to the lack of expected indicators and targeting specificity of current medical technology, subjecting patients to very uncomfortable physical and mental experiences and high medical costs. Therefore, the requirements for treatments with higher specificity and indicative ability are raised. Fortunately, the discovery of and continuous research investigating circular RNAs (circRNAs) represent a promising method among numerous methods. Although circRNAs wear regarded as metabolic wastes when discovered, as a type of noncoding RNA (ncRNA) with a ring structure and wide distribution range in the human body, circRNAs shine brilliantly in medical research by virtue of their special nature and structure-determined functions, such as high stability, wide distribution, high detection sensitivity, acceptable reproducibility and individual differences. Based on research investigating the role of circRNAs in immunity, we systematically discuss the hotspots of the roles of circRNAs in immune-related diseases, including expression profile analyses, potential biomarker research, ncRNA axis/network construction, impacts on phenotypes, therapeutic target seeking, maintenance of nucleic acid stability and protein binding research. In addition, we summarize the current situation of and problems associated with circRNAs in immune research, highlight the applications and prospects of circRNAs in the treatment of immune-related diseases, and provide new insight into future directions and new strategies for laboratory research and clinical applications.

show abstract

“…Therefore, the use of mTOR inhibitors increases the expression of GAS5. For several cancers, the suppression of GAS5 and mTOR expression has been shown to be reciprocal [27,29]. It was suggested that these ORFs can "collect" ribosomes on themselves without protein synthesis, acting as a "sponge" for ribosomes [12].…”

Section: Protein Synthesismentioning

confidence: 99%

“…GAS5 increases the expression of PTEN in several ways [67,68] and increases the expression of FOXO1 [54]. Moreover, in breast cancer, as in other types of cancer [27,29], the suppression of mTOR and GAS5 may be mutual. Current knowledge thus implicates GAS5 as a promising therapeutic target in breast cancer.…”

Section: Ptenmentioning

confidence: 99%

Long Noncoding RNA GAS5 in Breast Cancer: Epigenetic Mechanisms and Biological Functions

Филиппова

Фридман

Burdennyy

et al. 2021

IJMS

View full text Add to dashboard Cite

Long noncoding RNAs (lncRNAs) have been identified as contributors to the development and progression of cancer through various functions and mechanisms. LncRNA GAS5 is downregulated in multiple cancers and acts as a tumor suppressor in breast cancer. GAS5 interacts with various proteins (e.g., E2F1, EZH2, and YAP), DNA (e.g., the insulin receptor promoter), and various microRNAs (miRNAs). In breast cancer, GAS5 binds with miR-21, miR-222, miR-221-3p, miR-196a-5p, and miR-378a-5p that indicates the presence of several elements for miRNA binding (MREs) in GAS5. Mediated by the listed miRNAs, GAS5 is involved in the upregulation of a number of mRNAs of suppressor proteins such as PTEN, PDCD4, DKK2, FOXO1, and SUFU. Furthermore, the aberrant promoter methylation is involved in the regulation of GAS5 gene expression in triple-negative breast cancer and some other carcinomas. GAS5 can stimulate apoptosis in breast cancer via diverse pathways, including cell death receptors and mitochondrial signaling pathways. GAS5 is also a key player in the regulation of some crucial signal pathways in breast cancer, such as PI3K/AKT/mTOR, Wnt/β-catenin, and NF-κB signaling. Through epigenetic and other mechanisms, GAS5 can increase sensitivity to multiple drugs and improve prognosis. GAS5 is thus a promising target in the treatment of breast cancer patients.

show abstract

lncRNA GAS5 inhibits malignant progression by regulating macroautophagy and forms a negative feedback regulatory loop with the miR‑34a/mTOR/SIRT1 pathway in colorectal cancer

Cited by 21 publications

References 38 publications

Research Progress of Long Non-Coding RNA GAS5 in Malignant Tumors

Research Progress of Long Non-Coding RNA GAS5 in Malignant Tumors

Past, Present and Future: The Relationship Between Circular RNA and Immunity

Long Noncoding RNA GAS5 in Breast Cancer: Epigenetic Mechanisms and Biological Functions

Contact Info

Product

Resources

About