LncRNA CD27-AS1 promotes acute myeloid leukemia progression through the miR-224-5p/PBX3 signaling circuit

Tao, Yanling; Zhang, Jingjing; Chen, Lulu; Liu, Xin; Yao, Mingkang; Zhang, Hao

doi:10.1038/s41419-021-03767-9

Cited by 20 publications

(8 citation statements)

References 60 publications

(62 reference statements)

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“…The biological function of CD27-AS1-208 has not been characterized until the present study. It is one of the transcripts of CD27-AS1, which is reported to be an unfavorable prognostic factor as its up-regulation has been documented to be significantly correlated with poorer survival of patients with colon adenocarcinoma or acute myeloid leukemia (AML) ( 52 , 53 ). Therefore, both our data and previous reports have illustrated the great potential of CD27-AS1 as a valuable therapeutic target.…”

Section: Discussionmentioning

confidence: 99%

Long Non-Coding RNA CD27-AS1-208 Facilitates Melanoma Progression by Activating STAT3 Pathway

Shi

Guo

et al. 2022

Front. Oncol.

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Melanoma is the most lethal skin cancer that originates from epidermal melanocytes. Recently, long non-coding RNAs (lncRNAs) are emerging as critical regulators of cancer pathogenesis and potential therapeutic targets. However, the expression profile of lncRNAs and their role in melanoma progression have not been thoroughly investigated. Herein, we firstly obtained the expression profile of lncRNAs in primary melanomas using microarray analysis and unveiled the differentially-expressed lncRNAs compared with nevus. Subsequently, a series of bioinformatics analysis showed the great involvement of dysregulated lncRNAs in melanoma biology and immune response. Further, we identified lncRNA CD27-AS1-208 as a novel nuclear-localized factor with prominent facilitative role in melanoma cell proliferation, invasion and migration. Mechanistically, CD27-AS1-208 could directly interact with STAT3 and contribute to melanoma progression in a STAT3-dependent manner. Ultimately, the role of CD27-AS1-208 in melanoma progression in vivo was also investigated. Collectively, the present study offers us a new horizon to better understand the role of lncRNAs in melanoma pathogenesis and demonstrates that CD27-AS1-208 up-regulation contributes to melanoma progression by activating STAT3 pathway. Targeting CD27-AS1-208 in melanoma cells can be exploited as a potential therapeutic approach that needs forward validation in clinical trials in the future.

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Section: Discussionmentioning

confidence: 99%

Long Non-Coding RNA CD27-AS1-208 Facilitates Melanoma Progression by Activating STAT3 Pathway

Shi

Guo

et al. 2022

Front. Oncol.

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“…To explore the effects of SNVs in lncRNAs, we performed DELncRNAs between mutated group and non-mutated group, and identified 20 SNV-associated lncRNAs including 7 lncRNAs and 13 mutations. One example is LncRNA CD27 antisense RNA 1( CD27-AS1 ), which is related to acute myeloid leukemia progression ( 68 ). In our study, we found that one mutation (chr11:65269611: -: TTTCC, Supplementary Table S12 ) in CD27-AS1 might up-regulate the expression of mutation tumor samples in SARC.…”

Section: Web Contents and Analysis Resultsmentioning

confidence: 99%

lncRNAfunc: a knowledgebase of lncRNA function in human cancer

Yang

Lü

et al. 2021

Nucleic Acids Research

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The long non-coding RNAs associating with other molecules can coordinate several physiological processes and their dysfunction can impact diverse human diseases. To date, systematic and intensive annotations on diverse interaction regulations of lncRNAs in human cancer were not available. Here, we built lncRNAfunc, a knowledgebase of lncRNA function in human cancer at https://ccsm.uth.edu/lncRNAfunc, aiming to provide a resource and reference for providing therapeutically targetable lncRNAs and intensive interaction regulations. To do this, we collected 15 900 lncRNAs across 33 cancer types from TCGA. For individual lncRNAs, we performed multiple interaction analyses of different biomolecules including DNA, RNA, and protein levels. Our intensive studies of lncRNAs provide diverse potential mechanisms of lncRNAs that regulate gene expression through binding enhancers and 3′-UTRs of genes, competing for miRNA binding sites with mRNAs, recruiting the transcription factors to gene promoters. Furthermore, we investigated lncRNAs that potentially affect the alternative splicing events through interacting with RNA binding Proteins. We also performed multiple functional annotations including cancer stage-associated lncRNAs, RNA A-to-I editing event-associated lncRNAs, and lncRNA expression quantitative trait loci. lncRNAfunc is a unique resource for cancer research communities to help better understand potential lncRNA regulations and therapeutic lncRNA targets.

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“…For instance, it was reported that lncRNA ANRIL could be used to regulate the development of AML by regulating the AdipoR1/AMPK/SIRT1's glucose metabolism pathway [ 29 ]. Tao and his group showed that downregulating CD27-AS1 could inhibit proliferation and induce apoptosis of AML cells through the miR-224-5p/PBX3 [ 30 ]. In recent years, several prognostic models based on lncRNAs were developed in different types of tumors [ 31 , 32 ].…”

Section: Discussionmentioning

confidence: 99%

Identification of the 7-lncRNA Signature as a Prognostic Biomarker for Acute Myeloid Leukemia

Liu

Guo

et al. 2021

Disease Markers

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A lot of evidence has emphasized the function of long noncoding RNAs (lncRNAs) in tumors’ development and progression. Nevertheless, there is still a lack of lncRNA biomarkers that can predict the prognosis of acute myeloid leukemia (AML). Our goal was to develop a lncRNA marker with prognostic value for the survival of AML. AML patients’ RNA sequencing data as well as clinical characteristics were obtained from the public TARGET database. Then, differentially expressed lncRNAs were identified in female and male AML samples. By adopting univariate and multivariate Cox regression analyses, AML patients’ survival was predicted by a seven-lncRNA signature. It was found that 95 abnormal expressed lncRNAs existed in AML. Then, the analysis of multivariate Cox regression showed that, among them, 7 (LINC00461, RP11-309M23.1, AC016735.2, RP11-61I13.3, KIAA0087, RORB-AS1, and AC012354.6) had an obvious prognostic value, and according to their cumulative risk scores, these 7 lncRNA signatures could independently predict the AML patients’ overall survival. Overall, the prognosis of AML patients could be predicted by a reliable tool, that is, seven-lncRNA prognostic signature.

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LncRNA CD27-AS1 promotes acute myeloid leukemia progression through the miR-224-5p/PBX3 signaling circuit

Cited by 20 publications

References 60 publications

Long Non-Coding RNA CD27-AS1-208 Facilitates Melanoma Progression by Activating STAT3 Pathway

Long Non-Coding RNA CD27-AS1-208 Facilitates Melanoma Progression by Activating STAT3 Pathway

lncRNAfunc: a knowledgebase of lncRNA function in human cancer

Identification of the 7-lncRNA Signature as a Prognostic Biomarker for Acute Myeloid Leukemia

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