Long Non-Coding RNA CD27-AS1-208 Facilitates Melanoma Progression by Activating STAT3 Pathway

Ma, Jingjing; Shi, Qiong; Guo, Sen; Xu, Peng; Yi, Xiuli; Yang, Yuqi; Zhang, Weigang; Liu, Yu; Liu, Lin; Qiao, Yi; Zhao, Tao; Gao, Tianwen; Guo, Weinan; Li, Chunying

doi:10.3389/fonc.2021.818178

Cited by 3 publications

(2 citation statements)

References 58 publications

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“…It is noteworthy that cd27-AS1 overexpression is also associated with a higher BR rate in these patients. This is in line with a previous report on cd27-AS1-208 found to be upregulated in melanoma and this marker is considered a valuable indicator of melanoma progression [45].…”

Section: Discussionsupporting

confidence: 93%

Critical Evaluation of Transcripts and Long Noncoding RNA Expression Levels in Prostate Cancer Following Radical Prostatectomy

et al. 2023

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Introduction: The clinical course of prostate cancer (PCa) is highly variable, ranging from indolent behavior to rapid metastatic progression. The Gleason score is widely accepted as the primary histologic assessment tool with significant prognostic value. However, additional biomarkers are required to better stratify patients, particularly those at intermediate risk. Methods: In this study, we analyzed the expression of 86 cancer hallmark genes in 171 patients with PCa who underwent radical prostatectomy and focused on the outcome of the 137 patients with postoperative R0-PSA0 status. Results: Low expression of the IGF1 and SRD52A, and high expression of TIMP2, PLAUR, S100A2, and CANX genes were associated with biochemical recurrence (BR), defined as an increase of prostate-specific antigen above 0.2 ng/mL. Furthermore, the analysis of the expression of 462 noncoding RNAs (ncRNA) in a sub-cohort of 39 patients with Gleason score 7 tumors revealed that high levels of expression of the ncRNAs LINC00624, LINC00593, LINC00482, and cd27-AS1 were significantly associated with BR. Our findings provide further evidence for tumor-promoting roles of ncRNAs in PCa patients at intermediate risk. The strong correlation between expression of LINC00624 and KRT8 gene, encoding a well-known cell surface protein present in PCa, further supports a potential contribution of this ncRNA to PCa progression. Conclusion: While larger and further studies are needed to define the role of these genes/ncRNA in PCa, our findings pave the way toward the identification of a subgroup of patients at intermediate risk who may benefit from adjuvant treatments and new therapeutic agents.

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Section: Discussionsupporting

confidence: 93%

Critical Evaluation of Transcripts and Long Noncoding RNA Expression Levels in Prostate Cancer Following Radical Prostatectomy

et al. 2023

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“…AC005261.3 is associated with colon cancer prognosis [25]. CD27-AS1 leads to acute malignant phenotype of myeloid leukemia [26] and malignant progression of melanoma [27]. DGUOK-AS1 promotes breast and cervical cancer progression through the miR-204-5p/IL-11 axis [28] and miR-499a-5p [28], respectively.…”

Section: Discussionmentioning

confidence: 99%

Prognostic characteristics and immune infiltration analysis of Kidney Renal Clear Cell Carcinoma based on m6A- associated lncRNA

Chen

Xiong

Yang

et al. 2023

Preprint

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Background: The m6A mutation may have a significant effect on non-coding RNA metabolism, ultimately contributing to tumor growth and metastasis. However, the mechanism of m6A-related lncRNAs in Kidney Renal Clear Cell Carcinoma (KIRC) has not yet been elucidated. Methods: Herein, we used transcriptional and clinical data from the TCGA to conduct the comprehensive analysis of m6A-related prognostic lncRNAs in KIRC. Twelve lncRNAs correlated with m6A were shown to be strongly associated with clinical prognosis. We utilized consensus clustering to classify these prognostic lncRNAs into two groups based on their expression levels in tumor tissue. The cluster B was significantly associated with higher expression levels of m6A-related prognostic lncRNAs and shorter patient survival. Subsequently, seven m6A-related lncRNAs were recognized to structure a predictive model, which were strongly correlated with tumor prognosis and could be employed as the independent prognostic factor. In the analysis of clinical correlation, it was shown that risk score was remarkably related with tumor metastasis. Finally, our analysis established correlation between infiltrating immune cells and m6A-related lncRNAs in KIRC patients. Results: As a result, we investigated m6A-related lncRNAs and the prognosis of KIRC to reveal the relationship between the 530 clinical samples and 611 transcriptome data showed that the prognostic model established by 12 high-risk lncRNAs can predict KIRC. The prognosis of patients, among which seven key m6A-related lncRNAs: AC005261.3, AC024060.2, AC079174.2, AL139123.1, AL355388.1, CD27-AS1, and DGUOK-AS1, were significantly associated with the overall survival and prognosis of KIRC. Conclusion: Overall, our results imply that m6A-related prognostic lncRNAs could be underlying biomarkers for immunotherapy in KIRC.

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SMG7-AS1 as a prognostic biomarker and predictor of immunotherapy responses for skin cutaneous melanoma

Xu¹,

Ju²,

Zhao³

et al. 2023

Genomics

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Long Non-Coding RNA CD27-AS1-208 Facilitates Melanoma Progression by Activating STAT3 Pathway

Cited by 3 publications

References 58 publications

Critical Evaluation of Transcripts and Long Noncoding RNA Expression Levels in Prostate Cancer Following Radical Prostatectomy

Critical Evaluation of Transcripts and Long Noncoding RNA Expression Levels in Prostate Cancer Following Radical Prostatectomy

Prognostic characteristics and immune infiltration analysis of Kidney Renal Clear Cell Carcinoma based on m6A- associated lncRNA

SMG7-AS1 as a prognostic biomarker and predictor of immunotherapy responses for skin cutaneous melanoma

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