LncRNA AB073614 regulates proliferation and metastasis of colorectal cancer cells via the PI3K/AKT signaling pathway

Wang, Yanan; Kuang, Haoyu; Xue, Jinfang; Liao, Liya; Yin, Fei; Zhou, Xiaojun

doi:10.1016/j.biopha.2017.07.024

Cited by 62 publications

(42 citation statements)

References 27 publications

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“…Increasing studies demonstrated that a considerable number of LncRNAs involve in the essential regulation processes of multiple types of cancers . The findings revealed that a wide variety of LncRNAs are frequently dysregulated in tumors, which are closely implicated in tumorigenesis and metastasis .…”

Section: Discussionmentioning

confidence: 99%

LINC00511 interacts with miR‐765 and modulates tongue squamous cell carcinoma progression by targeting LAMC2

Ding

Yang

2018

J Oral Pathology Medicine

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Section: Discussionmentioning

confidence: 99%

LINC00511 interacts with miR‐765 and modulates tongue squamous cell carcinoma progression by targeting LAMC2

Ding

Yang

2018

J Oral Pathology Medicine

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“…For example, Liu et al showed that enhanced expression of lncRNA Sox2ot promoted cell proliferation and motility in colorectal cancer [20]. Wang et al revealed that lncRNA AB073614 regulated proliferation and metastasis of colorectal cancer cells via the PI3K/AKT signaling pathway [21]. Liu et al suggested that lncRNA SPRY4-IT1 promoted proliferation and invasion by acting as a ceRNA of miR-101-3p in colorectal cancer cells [22].…”

Section: Discussionmentioning

confidence: 99%

Long non-coding RNA ZFAS1 sponges miR-484 to promote cell proliferation and invasion in colorectal cancer

Xie

Wang

et al. 2018

Cell Cycle

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The incidence and mortality rate of colorectal cancer (CRC) have been significantly increasing. However, mechanisms involved in CRC progression are still unclear. LncRNA ZFAS1 has been verified as oncogenic molecular in a series of tumors, including CRC. However, the underlying mechanism of ZFAS1 in CRC carcinogenesis remains unclear. In the present study, our data showed that ZFAS1 expression was significantly upregulated in CRC tissues and cell lines. Correlation analysis showed that high ZFAS1 expression was significantly associated with Helicobacter pylori infection, lymph nodes metastasis, advanced TNM stage and poor overall survival of CRC patients. Loss-of-function experiments revealed that ZFAS1 inhibition could markedly suppress CRC cells proliferation and invasion both in vitro and in vivo. Bioinformatics analysis and luciferase reporter assay revealed that ZFAS1 directly interacted with miR-484. Rescue experiments showed that miR-484 inhibitor reversed the tumor suppressing roles of ZFAS1 knockdown on CRC cells. Therefore, our study suggested that ZFAS1 could act as an oncogene in CRC tumorigenesis, and discovered the functional regulatory pathway of ZFAS1 sponging miR-484.

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“…30 Previous study has indicated that 740 Y-P could abolish silencing of LncRNA AB073614 on the role of cell proliferation and apoptosis in colorectal cancer. 31 Similarly, Zhang H et al 32 has revealed that 740 Y-P also could elimate phellamurin on the effect of in OS. In our research, we discovered that overexpressed NCRNA00173 could inhibit the expression of p-PI3K and p-Akt, as well as 740 Y-P reversed the proteins level of VEGF, Cyclin D1, P70S6K and p-P70S6K and the proliferative, migrated and invasive capacity induced by NCRNA00173.…”

Section: Discussionmentioning

confidence: 94%

LncRNA NCRNA00173 is down-regulated in pediatric osteosarcoma and suppresses cell metastasis of osteosarcoma cells through regulating PI3k/Akt pathway

Zhao¹,

Chen²,

Xia³

2019

Preprint

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Background: Osteosarcoma (OS) is a primary malignant tumor with high mortality and disability rate in childhood and adolescent, whereas the influence of LncRNA00173 (NCRNA00173) on pediatric OS progression is not obvious yet. Therefore, this study aimed to investigate the expression of NCRNA00173 in pediatric OS and its effect on OS progression. Methods: In our study, qRT-PCR was adopted to test the NCRNA00173 expression in 40 pairs of pediatric OS tissues and OS cell lines. Kaplan-Meier method and Cox proportional hazard model were performed to analyze the prognosis of pediatric OS patients. The cell proliferation, apoptosis, migration and invasion of U2OS and HOS cells were test by MTT assay, flow cytometry, wound-healing, and transwell assay, respectively. The protein expression levels of PI3K/Akt pathway were measured by western blot. In addition, tumor growth in nude mice was also detected. Results: The expression of NCRNA00173 was down-regulated and relevant with poor prognosis in pediatric OS. Overexpression of NCRNA00713 inhibited cell proliferation, migration and invasion, as well as accelerated cell apoptosis in U2OS and HOS cells. Overexpression of NCRNA00713 suppressed tumor growth in nude mice. The protein expression of p-PI3K and p-Akt were remarkedly decreased in U2OS and HOS cells after transfection with NCRNA00173. In addition, 740 Y-P (PI3K/Akt pathway activator) eliminated the impact of NCRNA00173 in HOS. Conclusions: NCRNA00173 was down-regulated in pediatric OS and suppressed metastasis of OS cells by regulating PI3k/Akt pathway.

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LncRNA AB073614 regulates proliferation and metastasis of colorectal cancer cells via the PI3K/AKT signaling pathway

Cited by 62 publications

References 27 publications

LINC00511 interacts with miR‐765 and modulates tongue squamous cell carcinoma progression by targeting LAMC2

LINC00511 interacts with miR‐765 and modulates tongue squamous cell carcinoma progression by targeting LAMC2

Long non-coding RNA ZFAS1 sponges miR-484 to promote cell proliferation and invasion in colorectal cancer

LncRNA NCRNA00173 is down-regulated in pediatric osteosarcoma and suppresses cell metastasis of osteosarcoma cells through regulating PI3k/Akt pathway

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