ln Vitro Virucidal Effect of Sanicula europaea L. Extract

Saniculoside N from Sanicula europaea L.

“…Sanicula europaea L. (Apiaceae) has been used as a traditional medicinal plant in the treatment of wounds, dermatological, gastrointestinal, upper airway, and urinary system diseases, and chronic chest pains , and in vitro virucidal effects in the phage−bacteria system, and antiinfluenza activity against influenza A. It was established that saponins are responsible for antimicrobial, hemolytic, and antioxidant activities, whereas hydroxycinnamic derivatives, especially rosmarinic acid, were responsible for antioxidant activity. , It was also reported that the presence of allantoin raised the value of the folk medicinal use of the plant …”

“…9,10 It was also reported that the presence of allantoin raised the value of the folk medicinal use of the plant. 11 Bioassay-directed fractionation of the aerial parts of S. europaea L., grown in Northeast Turkey, led to the isolation of rosmarinic acid (2) as the most active constituent against HIV-1. In addition, a new saponin, saniculoside N (1), and caffeic acid (3) were isolated as major components, and the aglycon of the new saponin, saniculagenin N (1a) was obtained as a product of acidic hydrolysis of 1 (Chart 1).…”