Saniculoside N from <i>Sanicula europaea</i> L.

Arda, Nazlı; Gören, Nezhun; Kuru, Avni; Pengsuparp, Thitima; Pezzuto, John M.; Qiu, Shaofu; Cordell, Geoffrey A.

doi:10.1021/np9701790

Cited by 23 publications

(15 citation statements)

References 15 publications

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“…In terms of the bioactivities of constituents of C. parvifolius, rosmarinic acid has been reported to show antiviral Arda et al, 1997), antithyrotropic (Auf'mkolk et al, 1985), anti-inflammatory (Englberger et al, 1988), antibacterial (Kuhnt et al, 1995) and antioxidative activities (Lamaison et al, 1990). Luteolin, a flavonoid, was reported to exhibit a smooth muscle relaxant property (Sanchez et al, 1996), an immunomodulatory effect (Liang et al, 1997), and anti-inflammatory (Pieroni and Pachaly, 2000), antitumor (Makino et al, 1998) and antiviral activities (Fesen et al, 1994).…”

Section: Resultsmentioning

confidence: 99%

HIV‐1 integrase inhibitory substances from Coleus parvifolius

Tewtrakul¹,

Miyashiro²,

Nakamura³

et al. 2003

Phytotherapy Research

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For the purpose of discovering anti-HIV-1 agents from natural sources, water and EtOH extracts of 50 Thai plants were screened for their inhibitory activity against HIV-1 integrase (IN), an enzyme essential for viral replication. Of these plants, an EtOH extract of Coleus parvifolius Benth. (aerial parts) showed potent activity against HIV-1 IN with an IC50 value of 9.2 microg/mL. From this extract, 11 compounds were isolated and identified as luteolin 5-O-beta-d-glucopyranoside (1), luteolin (2), luteolin 7-methyl ether (3), luteolin 5-O-beta-d-glucuronide (4), 5-O-beta-d-glucopyranosyl-luteolin 7-methyl ether (5), rosmarinic acid (6), rosmarinic acid methyl ester (7), daucosterol (8), a mixture of alpha- and beta-amyrin (9, 10) and phytol (11). Of these compounds, rosmarinic acid methyl ester (7), rosmarinic acid (6), luteolin (2) and luteolin 7-methyl ether (3) exhibited inhibitory activities against HIV-1 IN with IC50 values of 3.1, 5.0, 11.0 and 11.0 microM, respectively. Among rosmarinic acid derivatives, the HIV-1 IN inhibitory activity increased in turn for a dimer (IC50 = 5.0 microM), a trimer (IC50 = 1.4 microM), and a tetramer (IC50 = 1.0 microM).

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Section: Resultsmentioning

confidence: 99%

HIV‐1 integrase inhibitory substances from Coleus parvifolius

Tewtrakul¹,

Miyashiro²,

Nakamura³

et al. 2003

Phytotherapy Research

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“…4 The occurrence of oleanane-type triterpenoid saponins, rosmarinic acid, caffeic acid and allantoin in S. europaea has been reported. [5][6][7] Investigations of biological activities have shown that S. europaea extracts posses antiviral, antimicrobial and antioxidant activities. [7][8][9] To the best of our knowledge, the essential oil of S. europaea has not been the subject of previous studies.…”

Section: Introductionmentioning

confidence: 99%

Essential oil composition ofSanicula europaea L.

et al. 2006

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The chemical composition of essential oils obtained by hydrodistillation from leaves of Sanicula europaea L. originating from two different localities in Serbia and Montenegro was analyzed using GC and GC-MS. The oils were characterized by a high content of sesquiterpene hydrocarbons (59.5-63.8%). The major compounds were found to be β β β β β-selinene (40.4-44.2%), caryophyllene oxide (17.9-19.2%) and α α α α α-selinene (3.7-4.0%).

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“…(þ )-(R)-Butyl ester of rosmarinic acid (1 )-(R)-1 (figure 1) isolated from Isodon oresbius in 1999 [1] was a derivative of rosmarinic acid which possesses various biological activities such as antioxidant [2], anti-HIV [3] and anti-inflammatory effects [4]. Two synthetic routes of the skeleton of rosmarinic acid have been reported [5,6].…”

Section: Introductionmentioning

confidence: 99%