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Bode, G.; Rothenbacher, Dietrich; Brenner, Hermann

doi:10.1023/a:1015618112695

Cited by 10 publications

(3 citation statements)

References 32 publications

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“…In support of this concept, a recent study demonstrated that another chronic infection (latent herpesvirus) conferred resistance to infection with two bacterial pathogens in a mouse model 150 . Several studies have suggested that H. pylori protects against diarrheal diseases 151, 152 , although this relationship has not been consistently observed 153 . Mechanisms for protection might include production of antibacterial peptides by H. pylori or the host 27, 107 , activating the immune system as an adjuvant 154 , competition for niche, or hypergastrinemia leading to maintainence of gastric acidity throughout childhood.…”

Section: Potential Benefits Of H Pylorimentioning

confidence: 98%

Helicobacter pylori in Health and Disease

2009

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Helicobacter pylori is highly adapted for colonization of the human stomach and is present in about half of the human population. When present, H. pylori is usually the numerically dominant gastric microorganism. H. pylori typically does not cause any adverse effects, but is associated with an increased risk of non-cardia gastric adenocarcinoma, gastric lymphoma and peptic ulcer. Disorders such as esophageal diseases and childhood-onset asthma have been recently reported to occur more frequently in individuals who lack H. pylori, compared with H. pylori-positive persons. In this review, we discuss biologic factors that allow H. pylori to colonize the human stomach, mechanisms by which H. pylori increases the risk for peptic ulcer disease and non-cardia gastric adenocarcinoma, and potential benefits that H. pylori might confer to humans.

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Section: Potential Benefits Of H Pylorimentioning

confidence: 98%

Helicobacter pylori in Health and Disease

2009

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“…H. pylori colonization has also been proposed to provide protection against various other infectious diseases. For example, H. pylori infection may protect against gastrointestinal infections and exogenous intestinal pathogens that cause diarrhea, but this relationship has not been consistently observed and may be due to recent changes in other factors ( 13 , 88 , 89 ). Specifically, as H. pylori prevalence has decreased with industrialization, other factors such as the introduction of clean water, improved sanitation, and less crowding also occurred and both therefore associate with the incidence of lethal diarrheal disease decreasing.…”

Section: Other Effects Of H Pylori Infectionmentioning

confidence: 99%

Helicobacter pylori infection causes both protective and deleterious effects in human health and disease

Miller

Williams

2021

Genes Immun

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Infection with Helicobacter pylori (H. pylori) is necessary but not sufficient for the development of gastric cancer, the third leading cause of cancer death globally. H. pylori infection affects over half of people globally; however, it does not affect populations uniformly. H. pylori infection rates are declining in Western industrialized countries but are plateauing in developing and newly industrialized countries where gastric cancer is most prevalent. Despite H. pylori infection being the primary causative agent for gastric cancer, H. pylori infection can also cause other effects, detrimental or beneficial, throughout an individual’s life, with the beneficial effects often being seen in childhood and the deleterious effects in adulthood. H. pylori is an ancient bacterium and its likelihood of affecting disease or health is dependent on both human and bacterial genetics that have co-evolved over millennia. In this review, we focus on the impact of infection and its genetic bases in different populations and diseases throughout an individual’s lifespan, highlighting the benefits of individualized treatment and argue that universal eradication of H. pylori in its host may cause more harm than good for those infected with H. pylori .

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“…[7] Further studies supported these observations with shigellosis [8] and typhoid fever. [9] On the other hand, other studies could not demonstrate such relation [10,11] and several studies from Germany [12,13] and the United States [14] showed inverse association between H pylori infection and diarrheal diseases. Given these controversies, we designed the current cross-sectional observational study to examine the impact of H pylori infection on the incidence of salmonella infections.…”

Section: Introductionmentioning

confidence: 99%

Helicobacter pylori infection and risk of salmonella infection

et al. 2019

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Helicobacter pylori ( H pylori ) infection is the most frequent infection worldwide and it has been postulated that it predisposes to multiple enteric pathogens and diarrheal diseases. Salmonella infection is common in tropical and under developed communities and is associated with wide range of diseases from gastroenteritis to typhoid fever. This study aimed at detecting the impact of H pylori infection on the incidence of salmonella infections. The study participants were sampled from cohorts of patients in four university hospitals in different Egyptian Governorates. Their age ranged from 20 to 59 years and followed up for a rising Widal test. Case patients ( n = 109) were subjects who visited the outpatient clinic because of diarrhea and typhoid like illness. They were either positive for H pylori stool antigen ( n = 53) or negative to it ( n = 56). All patients were subjected to thorough history taking, clinical examination, routine laboratory investigations, abdominal ultrasonography, H pylori stool antigen detection, and serial Widal test assay. The proportion of salmonella-infected subjects was lower among case patients with H pylori infection (22.6%) than among those negative for H pylori (33.9%) albeit not statistically significant (adjusted odds ratio [OR], 0.57; 95% confidence interval [CI], 0.24–1.33; P = .21). The association persisted nonsignificant after adjusting for sociodemographic variables (adjusted OR, 0.5; 95% CI, 0.18–1.39; P = .18). In a multivariate analysis that adjusted for sex, dietary habits, socioeconomic status, and educational level subjects who eat outdoors were associated with a significantly greater risk of salmonella typhi infection. Our findings suggest that there is no association between H pylori infection and salmonella infection in patients presented with typhoid fever or typhoid like illness.

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Untitled

Cited by 10 publications

References 32 publications

Helicobacter pylori in Health and Disease

Helicobacter pylori in Health and Disease

Helicobacter pylori infection causes both protective and deleterious effects in human health and disease

Helicobacter pylori infection and risk of salmonella infection

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