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Yd, Sanzgiri; Cd, Blanton; Gallo, Jean‐Marc

doi:10.1023/a:1015887910184

Cited by 18 publications

(9 citation statements)

References 5 publications

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“…Orally administered as well as implantable delivery systems containing chitosan as a drug carrier have been prepared to effect sustained release of the drug 12, 13. Modulation of drug release has been achieved by drug–chitosan complexation involving ionic14–16 or covalent interactions 17, 18. While the focus for ionic interactions of chitosan involves the amino groups of its glucosamine residues, covalent interactions often involve other sites as well (e.g., the CH 2 OH moieties).…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of chitosan‐polycaprolactone blended with organoclay for control release of doxycycline

Sahoo¹,

Sasmal²,

Nayak³

2010

J of Applied Polymer Sci

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In the present research program, chitosan has been mixed with polycaprolactone (PCL) (80 : 20) for using them for control delivery of doxycycline. Organoclay, Cloisite 30B of different concentrations 1, 2.5, and 5% has been blended with the composite. Chitosan is a natural biodegradable polymer where as polycaprolactone is a synthetic biopolymer. The blending of the two polymers has been carried out varying the proportion of nanoclay so that the composite can be a better drug carrier. The blends were characterized by Fourier Transmission Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), Xray Diffraction (XRD) analysis. From the FTIR spectra, the various groups present in chitosan and PCL blend were monitored. The homogeneity, morphology, and crystallinity of the blends were ascertained from SEM and XRD data, respectively. The swelling studies have been carried out at different drug loading. Swelling study is an important parameter to predict the diffusion of the drugs from the matrix. The kinetics of the drug delivery system has been systematically studied. Drug release kinetics was analyzed by plotting the cumulative release data versus time by fitting to an exponential equation which indicated the non-Fickian type of kinetics. The drug release was investigated at different pH medium, and it was found that the drug release depends upon the pH medium as well as the nature of matrix.

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Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of chitosan‐polycaprolactone blended with organoclay for control release of doxycycline

Sahoo¹,

Sasmal²,

Nayak³

2010

J of Applied Polymer Sci

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“…[1][2][3][4][5] Generally, chitosan dissolves aqueous acidic medium below pH 6.5, it precipitates above this pH by the addition of alkali solution. The application of chitosan was limited for using as a drug carrier owing to the insolubility at neutral or high pH region.…”

Section: Introductionmentioning

confidence: 99%

Preparation of <i>N</i>-Succinyl-chitosan and Their Physical-Chemical Properties as a Novel Excipient

Yan

Chen

et al. 2006

YAKUGAKU ZASSHI

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The aim of this work is to prepare N-succinyl-chitosan (Suc-Chi) and measure physical-chemical properties for Suc-Chi as excipients. Suc-Chi were prepared via ring-opening reactions with succinic anhydride in Dimethyl Sulfoxide system. The physical-chemical properties of Suc-Chi, such as the degree of substitution (DS), solubility, isoelectric point (pI), glass transition temperature (Tg), partition coe‹cient (P app ) and zata potential were detected respectively in order to evaluate their possibility as drug carriers. We obtained Suc-Chi DAC-90 (DS＝0.33) and the data of physicalchemical properties for the product. The knowledges of physical-chemical properties for Suc-Chi are valuable for basic or applied purposes in biomedical and pharmaceutical sciences stabilization.

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“…Once bacterial cells adhere to the surface of the implants, bacteria can form a biofilm, which acts as a barrier to host defense mechanisms and resists to antimicrobial agents 40, 41 . CH and its derivatives have received significant scientific interests in surface modification for antibacterial, medical and pharmaceutical applications 30, 42–44 . Due to the presence of CH in CH-Ti and CH-MTX-Ti substrates, these substrates show significant resistance to the adhesion of S. aureus (Fig.…”

Section: Discussionmentioning

confidence: 99%

Chemical functionalization of bone implants with nanoparticle-stabilized chitosan and methotrexate for inhibiting both osteoclastoma formation and bacterial infection

et al. 2014

J. Mater. Chem. B

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A great challenge in orthopedic tumor operation faced by orthopedic implants is the high recurrence and metastasis of bone tumor as well as the bacterial infection associated with the implants. Thus ideal titanium (Ti)-based bone implants should be able to not only inhibit cancer cell adhesion and proliferation, promote cancer cell apoptosis, but also resist bacterial infections. Towards this end, we developed a new approach to modify the surface of Ti-based bone implants so that they can restrain functions of osteoclastoma (Giant cell tumor of bone) cancer cells (GCTs) and inhibit the adhesion of bacteria. First, the surface of pristine Ti substrates was functionalized with dopamine (DA) to form DA-Ti substrates. Then nanoparticles electrostatically assembled from poly-lysine (PLL) and heparin (Hep) were chemically immobilized onto the DA-Ti substrates to form PLL/Hep-Ti substrates. Chitosan (CH) and methotrexate (MTX) were then electrostatically immobilized onto the PLL/Hep-Ti substrates to generate CH-MTX-Ti substrates. The successful functionalization of the Ti substrates was confirmed by X-ray photoelectron spectroscopy. GCTs cultured on differently functionalized Ti substrates were investigated in terms of cell adhesion, cytoskeleton, proliferation, cytotoxicity and apoptosis. The growth of Staphylococcus aureus bacteria in the presence of different substrates was also assayed. Our results showed that CH-MTX-Ti substrates not only significantly inhibited the adhesion, proliferation and viability of GCTs, promoted the apoptosis of GCTs, but also prevented the adhesion of the bacteria and the subsequent formation of bacterial biofilms, when compared to other Ti substrates. Thus CH-MTX-Ti substrates are expected to be used as orthopedic prostheses in bone tumor surgery that can inhibit both osteoclastoma formation and bacterial infections.

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Cited by 18 publications

References 5 publications

Synthesis and characterization of chitosan‐polycaprolactone blended with organoclay for control release of doxycycline

Synthesis and characterization of chitosan‐polycaprolactone blended with organoclay for control release of doxycycline

Preparation of <i>N</i>-Succinyl-chitosan and Their Physical-Chemical Properties as a Novel Excipient

Chemical functionalization of bone implants with nanoparticle-stabilized chitosan and methotrexate for inhibiting both osteoclastoma formation and bacterial infection

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