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Li, Shihong; Liu, Qing; Wijn, Joost de; Wolke, Joop G.C.; Zhou, Benlian; Groot, K. de

doi:10.1023/a:1018546730925

Cited by 31 publications

(11 citation statements)

References 5 publications

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“…It has been observed by several investigators that functionalized polymers with surface bound phosphate group induces in vitro nucleation of calcium phosphate crystals on their surface under simulated physiological environment. 33–35 However, many of these surface functionalized polymers require pretreatments such as calcium hydroxide/calcium chloride pretreatment after functionalization for the in vitro mineralization of calcium phosphate. Moreover the popular surface phosphorylation techniques are done at higher temperature (<100°C), using organic solvents and catalysts, which may alter the basic polymer characteristics significantly.…”

Section: Discussionmentioning

confidence: 99%

Effect of surface functionalization on the physicomechanical properties of a novel biofunctional copolymer

Sailaja

Ramesh

Varma

2011

J of Applied Polymer Sci

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The physicomechanical properties of functionally active poly(hydroxyethyl methacrylate-co-methyl methacrylate) [poly(HEMA-co-MMA)] are evaluated. It has been reported that the surface phosphorylated poly(HEMAco-MMA) is capable of eliciting direct bone bonding when implanted in vivo. Hence, it is important to examine the physicomechanical property of the copolymer as a function of surface modification. The properties assessed are differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), equilibrium swelling, compressive strength, and dynamic mechanical analysis. According to the DSC data, the glass transition temperature, T g of poly(HEMA -co-MMA) is not significantly altered by surface phosphorylation. The TGA results demonstrated that unmodified and surface phosphorylated copolymers have similar degrada-tion profile. The differential thermal analysis further supports the data. The equilibrium swelling of functionalized poly(HEMA-co-MMA) in phosphate buffer saline ascertained that surface phosphorylation significantly increased the hydrophilicity of the copolymer. The study further illustrated that the percentage of equilibrium swelling appreciably increases with increase in HEMA content in the copolymer and reached a plateau after 100 h. Both compressive strength and compressive modulus of poly (HEMAco-MMA) decreased due to surface phosphorylation while dynamic storage modulus value was not altered.

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Section: Discussionmentioning

confidence: 99%

Effect of surface functionalization on the physicomechanical properties of a novel biofunctional copolymer

Sailaja

Ramesh

Varma

2011

J of Applied Polymer Sci

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“…Synthetic calcium phosphates generally induce the formation of an apatite layer in simulated plasma solutions. Some other synthetic biomaterials have also shown the capability of inducing the formation of an apatitic mineral, namely polymers containing phosphate functionalities,35–38 including phosphorylated cellulose derivatives 39–41. However, only low degrees of phosphorylation were used because of the lack of techniques that would allow highly phosphorylated products to be obtained.…”

Section: Introductionmentioning

confidence: 99%

Cellulose phosphates as biomaterials. I. Synthesis and characterization of highly phosphorylated cellulose gels

Granja

Pouységu²,

Pétraud³

et al. 2001

J of Applied Polymer Sci

140

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ABSTRACT:The present study concerns the investigation of a material expected to be biocompatible and able to promote bone regeneration. For this purpose, cellulose was chemically modified by phosphorylation. Once implanted, phosphorylated cellulose could promote the formation of calcium phosphates, thus having closer resemblance to bone functionality. In a previous investigation, the obtention and the preliminary characterization of cellulose phosphate gels were reported. In the present study, the synthesis by the H 3 PO 4 /P 2 O 5 /Et 3 PO 4 /hexanol method was optimized in terms of reaction parameters. The structure of materials was investigated by FTIR, Raman, and solid-state 31 P-and 13 C-NMR spectroscopic studies, and X-ray diffraction. Water swelling and stability to sterilization by gamma-radiation were also assessed. It was demonstrated that the present method allows highly phosphorylated cellulose derivatives to be obtained. Cellulose triphosphates gels are described here for the first time. Products obtained were poorly crystallized monoesters, apparently not significantly affected by gamma sterilization and showed a high water swelling capability. Chemical bonding was confirmed by FTIR, Raman, and both 31 P-and 13 C-NMR spectroscopies. It was also shown that the H 3 PO 4 / P 2 O 5 /Et 3 PO 4 /hexanol method provides a versatile and interesting alternative route to some of the more widely used techniques for the phosphorylation of cellulose.

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“…Among these, surface phosphorylation has been identified as an effective method for surface functionalization [117–119]. Varma et al demonstrated formation of calcium phosphate coating on chitosan by direct phosphorylation while PMMA required surface functionalization by coupling with ATP molecule elicit HAP coating [120].…”

Section: Biomimetic Mineralizationmentioning

confidence: 99%

“…Surface phosphorylated poly(vinyl alcohol), PVA exhibited enhanced cytocompatibility in vitro in addition to substantial apatite coating [121]. Instead of urea-phosphoric acid method, Li et al [117] employed sodium hydroxide-phosphoric acid for phosphorylating bamboo while Granja et al [122] phosphorylated regenerated cellulose with the aid of phosphoric acid and triethyl phosphate. In another study, the authors presented an alternative way for surface phosphorylation illustrated with poly (hydroxyl ethyl methacrylate-co methyl methacrylate) for biomimetic growth of calcium phosphate [119], and the functionalized material was demonstrated to direct bone bonding and elicited new bone formation [118].…”

Section: Biomimetic Mineralizationmentioning

confidence: 99%

Biomimetic approaches with smart interfaces for bone regeneration

et al. 2016

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A ‘smart tissue interface’ is a host tissue-biomaterial interface capable of triggering favourable biochemical events inspired by stimuli responsive mechanisms. In other words, biomaterial surface is instrumental in dictating the interface functionality. This review aims to investigate the fundamental and favourable requirements of a ‘smart tissue interface’ that can positively influence the degree of healing and promote bone tissue regeneration. A biomaterial surface when interacts synergistically with the dynamic extracellular matrix, the healing process become accelerated through development of a smart interface. The interface functionality relies equally on bound functional groups and conjugated molecules belonging to the biomaterial and the biological milieu it interacts with. The essential conditions for such a special biomimetic environment are discussed. We highlight the impending prospects of smart interfaces and trying to relate the design approaches as well as critical factors that determine species-specific functionality with special reference to bone tissue regeneration.

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Cited by 31 publications

References 5 publications

Effect of surface functionalization on the physicomechanical properties of a novel biofunctional copolymer

Effect of surface functionalization on the physicomechanical properties of a novel biofunctional copolymer

Cellulose phosphates as biomaterials. I. Synthesis and characterization of highly phosphorylated cellulose gels

Biomimetic approaches with smart interfaces for bone regeneration

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