Biomimetic approaches with smart interfaces for bone regeneration

Abstract

A ‘smart tissue interface’ is a host tissue-biomaterial interface capable of triggering favourable biochemical events inspired by stimuli responsive mechanisms. In other words, biomaterial surface is instrumental in dictating the interface functionality. This review aims to investigate the fundamental and favourable requirements of a ‘smart tissue interface’ that can positively influence the degree of healing and promote bone tissue regeneration. A biomaterial surface when interacts synergistically with the dynamic extracellular matrix, the healing process become accelerated through development of a smart interface. The interface functionality relies equally on bound functional groups and conjugated molecules belonging to the biomaterial and the biological milieu it interacts with. The essential conditions for such a special biomimetic environment are discussed. We highlight the impending prospects of smart interfaces and trying to relate the design approaches as well as critical factors that determine species-specific functionality with special reference to bone tissue regeneration.

Osseointegration of layer-by-layer polyelectrolyte multilayers loaded with IGF1 and coated on titanium implant under osteoporotic condition

“…24,29 The final stage of osteogenic differentiation is the mineralization of ECM, and the mineralized nodule is an important functional marker of mature bone cells. 30 Our study here suggests that the functionalized structure could promote all of these processes.…”

Blueprints for the Next Generation of Bioinspired and Biomimetic Mineralised Composites for Bone Regeneration

“…In bone tissue engineering, various biomimetic approaches [76,77] have been taken to explore solutions for repairing a critical bone defect. The principal objective in bone repair is to design a scaffold that, in most instances, will support mechanical load, facilitate vascularisation and stimulate osteoblast cell mineralisation, without invoking a chronic inflammatory response.…”

“…However, they are an excellent candidate as an additive to composite materials used in bone repair. Recent advances in the field have started to place more emphasis on the importance of “ smart interfaces ”, whereby the biomaterial interface triggers a favourable cellular response [77]. Topography, particularly nano-sized surface topography, is considered to have a positive effect on cellular response [85,86].…”

Тканеинженерные Конструкции Для Регенеративной Медицины На Основе Мезенхимальных Клеток Пульпы Молочного Зуба И Полимерных Матриксов Нового Поколения

“…В общем виде они направлены на активацию регенеративного потенциала пациента и создания в области дефекта оптимальных условий для восстановления. Основным инструментом регенеративной медицины являются методы тканевой инженерии, как правило, подразумевающие имплантацию в зону повреждения мультипотентных клеток, иммобили-зованных на клеточном носителе, или матриксе, выполняющем функции трехмерного каркаса [12]. К матриксу предъявляется ряд критически важных требований, таких как возможность обеспечения адгезии достаточного количества клеток и их последующей пролиферации и дифференцировки, а также миграции прогениторных клеток со стороны организма реципиента.…”