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Newell, Helen; Buckton, Graham; Butler, David A.; Thielmann, Frank; Williams, Daryl R.

doi:10.1023/a:1011089511959

Cited by 126 publications

(22 citation statements)

References 5 publications

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“…[69]. These workers examined differences in

{normalγ}_{S}^{d}

due to processing induced disorder so as to understand the effects of disorder on lactose particle surfaces.…”

Section: Millingmentioning

confidence: 99%

Particle Engineering in Pharmaceutical Solids Processing: Surface Energy Considerations

Williams

2015

CPD

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During the past 10 years particle engineering in the pharmaceutical industry has become a topic of increasing importance. Engineers and pharmacists need to understand and control a range of key unit manufacturing operations such as milling, granulation, crystallisation, powder mixing and dry powder inhaled drugs which can be very challenging. It has now become very clear that in many of these particle processing operations, the surface energy of the starting, intermediate or final products is a key factor in understanding the processing operation and or the final product performance. This review will consider the surface energy and surface energy heterogeneity of crystalline solids, methods for the measurement of surface energy, effects of milling on powder surface energy, adhesion and cohesion on powder mixtures, crystal habits and surface energy, surface energy and powder granulation processes, performance of DPI systems and finally crystallisation conditions and surface energy. This review will conclude that the importance of surface energy as a significant factor in understanding the performance of many particulate pharmaceutical products and processes has now been clearly established. It is still nevertheless, work in progress both in terms of development of methods and establishing the limits for when surface energy is the key variable of relevance.

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“…[69]. These workers examined differences in

{normalγ}_{S}^{d}

due to processing induced disorder so as to understand the effects of disorder on lactose particle surfaces.…”

Section: Millingmentioning

confidence: 99%

Particle Engineering in Pharmaceutical Solids Processing: Surface Energy Considerations

Williams

2015

CPD

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“…IGC can be applied to study the solubility parameters of some solid surfaces as titanate modified silica gel [19] or to compare the surface energies of crystalline, amorphous, and ball milled lactose [20], to study the heterogeneous surfaces [21] and textile products and their physicochemical properties [22], and to determine surface energy and surface area of powdered materials [23,24].…”

Section: Introductionmentioning

confidence: 99%

Effect of the Tacticity of PMMA Adsorbed on Alumina and Silica on the Specific Entropy Change of Polymer by Inverse GC

2011

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Inverse gas chromatography (IGC) at infinite dilution is a powerful technique to characterize the superficial and interfacial properties of solid substrates as oxides, polymers or polymers adsorbed on oxides. It can also be used to determine the physicochemical properties and the transition phenomena of polymers. In this paper, IGC was used to determine the changes, as a function of temperature, of the specific free enthalpy DG a SP and deduce the specific entropy DS a SP of poly (methyl methacrylate) (PMMA) adsorbed on alumina or on silica for different tacticities of PMMA. The study of the surface properties of PMMA/SiO 2 and PMMA/Al 2 O 3 , revealed an important difference in the physicochemical behaviour of oxides covered by various concentrations of PMMA. This study also highlighted an important effect of the tacticity of the polymer on the specific entropy of PMMA adsorbed on oxides.

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“…Recently, utilization of IGC is growing rapidly and evaluation of pharmaceutical materials such as mannitol, lactose monohydrate, trehalose and albuterol has been reported. [16][17][18][19] Though it is said more research is required for the fundamental understanding of this technique, IGC is considered to be a powerful tool to characterize powder surface. 20) In this study, we evaluated mechanofusion-processed lactose as a carrier for DPI containing Compound A, and evaluated the surface property of the lactose by IGC.…”

mentioning

confidence: 99%

Novel Approach to DPI Carrier Lactose with Mechanofusion Process with Additives and Evaluation by IGC

et al. 2006

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Abstract: Milling had made the surface energy similar to that of the amorphous material in a manner that was very different to a physical mixture of the same amorphous content. The milled material will have similar interfacial interactions to the 100% amorphous material.

Cited by 126 publications

References 5 publications

Particle Engineering in Pharmaceutical Solids Processing: Surface Energy Considerations

Particle Engineering in Pharmaceutical Solids Processing: Surface Energy Considerations

Effect of the Tacticity of PMMA Adsorbed on Alumina and Silica on the Specific Entropy Change of Polymer by Inverse GC

Novel Approach to DPI Carrier Lactose with Mechanofusion Process with Additives and Evaluation by IGC

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