Living scaffolds: surgical repair using scaffolds seeded with human adipose-derived stem cells

Klinger, Aaron; Kawata, Michitaka; Villalobos, Miguel; Jones, Robert B.; Pike, Steven L.; Wu, Nan; Chang, Shaohua; Zhang, P.; DiMuzio, Paul; Vernengo, Jennifer; Benvenuto, Pasquale; Goldfarb, Roy D.; Hunter, K.; Liu, Y.; Carpenter, Jeffrey P.; Tulenko, Thomas N.

doi:10.1007/s10029-015-1415-0

Cited by 24 publications

(14 citation statements)

References 32 publications

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“…Permanent meshes seem essential for patients with medial hernias due to the more profound connective tissue alteration. Animal studies have assessed the effect of adding stem cells to meshes with somewhat promising results ( 103 , 104 ). Hopefully, stem cell-coated meshes could be a method to lower the recurrence rate after medial hernia repairs, and perhaps be considered for individuals with a family history of inguinal hernias due to the increased risk of earlier recurrences ( 82 ).…”

Section: Discussionmentioning

confidence: 99%

Etiology of Inguinal Hernias: A Comprehensive Review

2017

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BackgroundThe etiology of inguinal hernias remains uncertain even though the lifetime risk of developing an inguinal hernia is 27% for men and 3% for women. The aim was to summarize the evidence on hernia etiology, with focus on differences between lateral and medial hernias.ResultsLateral and medial hernias seem to have common as well as different etiologies. A patent processus vaginalis and increased cumulative mechanical exposure are risk factors for lateral hernias. Patients with medial hernias seem to have a more profoundly altered connective tissue architecture and homeostasis compared with patients with lateral hernias. However, connective tissue alteration may play a role in development of both subtypes. Inguinal hernias have a hereditary component with a complex inheritance pattern, and inguinal hernia susceptible genes have been identified that also are involved in connective tissue homeostasis.ConclusionThe etiology of lateral and medial hernias are at least partly different, but the final explanations are still lacking on certain areas. Further investigations of inguinal hernia genes may explain the altered connective tissue observed in patients with inguinal hernias. The precise mechanisms why processus vaginalis fails to obliterate in certain patients should also be clarified. Not all patients with a patent processus vaginalis develop a lateral hernia, but increased intraabdominal pressure appears to be a contributing factor.

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Section: Discussionmentioning

confidence: 99%

Etiology of Inguinal Hernias: A Comprehensive Review

2017

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“…The addition of autologous or allogeneic muscle progenitor cells, satellite cells, mesenchymal stem cells, or adipose‐derived stem cells to ECM has been explored for VML treatment . Cell‐seeded ECM scaffolds seek to combine the proregenerative features of cellular and matrix factors to enhance overall regenerative capacity.…”

Section: Promoting Muscle Regenerationmentioning

confidence: 99%

Extracellular matrix scaffolds for treatment of large volume muscle injuries: A review

et al. 2018

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“…First, there is a lack of uniformity regarding the use of animal models in preclinical trials (Vogels et al, 2017). Even the most recent studies that have investigated the use of stem cells on surgical meshes have been performed in vitro (Gao et al, 2014;Vozzi et al, 2017) or in small animal models, especially in mice (Darzi et al, 2018;Paul et al, 2019;Mukherjee et al, 2020), rats (Altman et al, 2010a;Altman et al, 2010b;Edwards et al, 2015;Iyyanki et al, 2015;Klinger et al, 2016;van Steenberghe et al, 2017;Hansen et al, 2020), and rabbits (Zhao et al, 2012;Cheng et al, 2017). Only a few preclinical studies have been performed in sheep (Gerullis et al, 2013;Gerullis et al, 2014).…”

Section: Discussionmentioning

confidence: 99%