Living-donor lobar lung transplantation for bronchiolitis obliterans after Stevens-Johnson syndrome

Date, Hiroshi; Sano, Yoshifumi; Aoe, Motoi; Goto, Keiji; Tedoriya, Takeo; Sano, Shunji; Andou, Akio; Shimizu, Nobuyoshi

doi:10.1067/mtc.2002.119331

Cited by 30 publications

(30 citation statements)

References 4 publications

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“…Six cases of severe respiratory failure, similar to that of the present patient, resulted in fatalities from 2 months to one and a half years after the onset of SJS/TEN (11,12,15,20,21,23). One patient developed progressive respiratory failure due to obliterative bronchiolitis, and underwent a living-donor lung transplantation 6 months after the onset of SJS (22). The other patients were discharged, but they all had prolonged respiratory complaints (13,14,(16)(17)(18)(19).…”

Section: Discussionsupporting

confidence: 63%

“…Fourteen cases of obliterative bronchitis or bronchiolitis following SJS/TEN have been reported (11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23). Two cases were thought to result from SJS brought on by mycoplasma infections (11,12), and 11 cases were thought to have been related to SJS / TEN caused by drugs (13)(14)(15)(16)(17)(18)(19)(21)(22)(23). Six cases of severe respiratory failure, similar to that of the present patient, resulted in fatalities from 2 months to one and a half years after the onset of SJS/TEN (11,12,15,20,21,23).…”

Section: Discussionmentioning

confidence: 99%

“…Lung transplantation is thought to be the only curative therapy for such a case (22). However, patients using mechanical ventilation for a long time, who have other complications and who cannot achieve total rehabilitation, are not candidates for lung transplantation.…”

Section: Discussionmentioning

confidence: 99%

“…However, there are only a few reports concerning chronic pulmonary complications in patients with SJS/TEN (11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23). We herein report a patient with SJS who had been diagnosed with severe obliterative bronchitis and died due to respiratory failure.…”

Section: Introductionmentioning

confidence: 93%

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Severe Obliterative Bronchitis Associated with Stevens-Johnson Syndrome

et al. 2011

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We report a case of Stevens-Johnson syndrome (SJS) in which the patient had been diagnosed with severe obliterative bronchitis. A 29-year-old woman was admitted with a high fever and a widespread vesicular rash. She was diagnosed with SJS and betamethasone administration was started. After one month, her vesicular skin rash improved; however, she developed respiratory failure and was assisted with mechanical ventilation.Computed tomography of the chest demonstrated a hyperlucent lung with narrowing of the peripheral vessels. Bronchoscopy revealed an occlusion of the bronchus when the patient exhaled. The flow-volume curve revealed a severe obstructive pattern. The patient was diagnosed with obliterative bronchitis following SJS. She was treated with a bronchodilator and steroids, but could not breathe adequately without the ventilator. During the following year, her PaCO2 increased to 100 torr and her heart function also continued to worsen. Despite intensive treatment, she died one year and seven months after the onset of SJS. In SJS and toxic epidermal necrolysis (TEN) patients, chronic pulmonary complications are rare, but there is no effective therapy for obliterative bronchitis following SJS/TEN. Therefore, early awareness of this condition is needed and lung transplantation must be considered at an early stage of this disease.

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Section: Discussionsupporting

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 93%

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Severe Obliterative Bronchitis Associated with Stevens-Johnson Syndrome

et al. 2011

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“…The principal indication is CF [53]. However, patients with other conditions such as primary pulmonary hypertension, pulmonary fibrosis, and obliterative bronchiolitis have also undergone successful bilateral lobar transplantation [54][55][56].…”

Section: Living Lobar Transplantationmentioning

confidence: 99%

Strategies to increase limited donor resources

Perrot¹,

Weder²,

Patterson³

et al. 2004

Eur Respir J

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A number of strategies have been advocated to increase the number of lung donors including: 1) improvement in donor resuscitation; 2) better methods of lung preservation; 3) extension of the lung donor selection criteria; 4) development of a living-related lung donor programme; and 5) utilisation of nonheart beating donors.Other strategies such as the split-lung technique and techniques of lung reduction to accommodate large lungs into a small-size recipient have also been used successfully. In this article, each of these strategies have been reviewed and some recommendations are suggested based on the authors9 own experience and that of the literature.

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An atypical presentation of pulmonary air‐leak syndrome and multisystem toxic epidermal necrolysis

Ellenburg

Josey

2014

Pediatric Pulmonology

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Toxic epidermal necrolysis (TEN) is a rare and potentially fatal mucocutaneous condition that may affect both children and adults. TEN mortality rates vary greatly between both patient populations, but multisystem involvement is common. Management presents many challenges as there is no specific therapy for TEN, and patients often require the expertise of burn units. We report a child who survived TEN with multisystem involvement including the rare but life threatening occurrence of a pulmonary air-leak syndrome while also reviewing controversies surrounding TEN's pathophysiology, sequelae, and multidisciplinary approach to management.

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Living-donor lobar lung transplantation for bronchiolitis obliterans after Stevens-Johnson syndrome

Cited by 30 publications

References 4 publications

Severe Obliterative Bronchitis Associated with Stevens-Johnson Syndrome

Severe Obliterative Bronchitis Associated with Stevens-Johnson Syndrome

Strategies to increase limited donor resources

An atypical presentation of pulmonary air‐leak syndrome and multisystem toxic epidermal necrolysis

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