Liver Transplantation for Nonalcoholic Steatohepatitis

Agopian, Vatche G.; Kaldas, Fady M.; Hong, Johnny C.; Whittaker, Meredith; Holt, Curtis; Rana, Abbas; Zarrinpar, Ali; Petrowsky, Henrik; Farmer, Douglas G.; Yersiz, Hasan; Xia, Victor W.; Hiatt, Jonathan R.; Busuttil, Ronald W.

doi:10.1097/sla.0b013e31826b4b7e

Cited by 219 publications

(208 citation statements)

References 39 publications

Supporting

Mentioning

194

Contrasting

Unclassified

Order By: Relevance

“…The prevalence of NAFLD in children and adolescents is also increasing. The increasing prevalence has resulted in an increasing need for NASH-related liver transplantation in the last 10 years [12] . Therefore, early diagnosis and treatment is quite important.…”

Section: Introductionmentioning

confidence: 99%

Importance of imaging and recent developments in diagnosis of nonalcoholic fatty liver disease

Koplay

Sivri

Erdoğan

et al. 2015

WJH

View full text Add to dashboard Cite

Nonalcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease and is a major public health problem worldwide. It is a spectrum that includes simple steatosis, nonalcoholic steatohepatitis (NASH), fibrosis and cirrhosis. Recently, NAFLD prevalence in children and adolescents has increased too. The increasing prevalence has resulted in NASH-related chronic liver disease. Therefore, early diagnosis and treatment is quite important. Although liver biopsy is still the gold standard for diagnosis and staging of NAFLD, particularly for the diagnosis of NASH, imaging methods such as ultrasonography, computed tomography, magnetic resonance imaging with chemical shift imaging and especially magnetic resonance spectroscopy and elastography have been increasingly approved as noninvasive alternative methods. The aim of this review is to analyze the diagnostic accuracy and limitations of the imaging methods and recent developments in the diagnosis of NAFLD.

show abstract

Section: Introductionmentioning

confidence: 99%

Importance of imaging and recent developments in diagnosis of nonalcoholic fatty liver disease

Koplay

Sivri

Erdoğan

et al. 2015

WJH

View full text Add to dashboard Cite

show abstract

“…Some studies failed to show differences in survival between patients transplanted due to NASH or other causes. 21,22,26,31 Malik et al 31 found no difference in survival between patients who underwent transplantation due to NASH who relapsed compared to those who did not relapse.…”

Section: Survivalmentioning

confidence: 99%

“…10,19,21,31 NODAT was observed in 10% to 36% of the population and was related to obesity, positive family history, glucose intolerance prior to transplantation and hepatitis C as the etiology of transplantation, in addition to immunosuppressants, especially calcineurin inhibitors. 53,62 Numerous studies have demonstrated a higher incidence of dyslipidemia and hypertension in posttransplant patients.…”

Section: Patients N Follow-up (Months) Mets (%) Dm (%) Nodat (%) Dyslmentioning

confidence: 99%

Nonalcoholic steatohepatitis in posttransplantation liver: Review article

Andrade

Cotrim

Bittencourt

et al. 2018

Rev. Assoc. Med. Bras.

View full text Add to dashboard Cite

Introduction: Nonalcoholic steatohepatitis (NASH) associated or not with cirrhosis is the third leading indication for liver transplantation (LT) around the world. After transplants, NASH has a high prevalence and occurs as both recurrent and de novo manifestations. De novo NASH can also occur in allografts of patients transplanted for non-NASH liver disease. Objective: To evaluate recurrent or de novo NASH in post-LT patients. Method: A literature review was performed using search engines of indexed scientific material, including Medline (by PubMed), Scielo and Lilacs, to identify articles published in Portuguese and English until August 2016. Eligible studies included: place and year of publication, prevalence, clinical characteristics, risk factors and survival. Results: A total of 110 articles were identified and 63 were selected. Most of the studies evaluated recurrence and survival after LT. Survival reached 90-100% in 1 year and 52-100% in 5 years. Recurrence of NAFLD (steatosis) was described in 15-100% and NASH, in 4-71%. NAFLD and de novo NASH were observed in 18-67% and 3-17%, respectively. Metabolic syndrome, diabetes mellitus, dyslipidemia and hypertension were seen in 45-58%, 18-59%, 25-66% and 52-82%, respectively. Conclusion: After liver transplants, patients present a high prevalence of recurrent and de novo NASH. They also show a high frequence of metabolic disorders. Nevertheless, these alterations seem not to influence patient survival.

show abstract

“…cause of chronic liver disease in paediatrics, NAFLD is threatening to become the leading indication for liver transplantation (LT) in adults after 2020 (2). This would potentially overstretch already overburdened LT services by a condition which is potentially preventable.…”

Section: Review Articlementioning

confidence: 99%