Paediatric Non Alcoholic Fatty Liver Disease: An Emerging Threat

Fitzpatrick, Emer; Hadžić, Nedim

doi:10.5457/p2005-114.104

Cited by 7 publications

(9 citation statements)

References 64 publications

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“…In developed countries, liver steatosis and NASH are becoming one of the common causes of paediatric chronic liver disorders today. In adults, the pattern of inflammation is usually lobular, and of fibrosis perivenular (Type 1 NASH), whereas in children it is periportal (type 2 NASH) (10,11). The inflammation and degree of fibrosis are the key prognostic parameters for advanced liver disease, which later on, usually in adulthood, may progress to cirrhosis (12).…”

Section: Fatty Livermentioning

confidence: 99%

“…The inflammation and degree of fibrosis are the key prognostic parameters for advanced liver disease, which later on, usually in adulthood, may progress to cirrhosis (12). Besides NAFLD, fatty accumulation in the liver may be part of different conditions, such as: cystic fibrosis, parenteral nutrition associated liver disease, malnutrition, some metabolic liver diseases such as Wilson, or may be toxic, such as drug induced liver disease (10).…”

Section: Fatty Livermentioning

confidence: 99%

“…Sensitivity and specificity are additionally decreased in very obese children (17). As many other different clinical conditions may also present with fatty liver, differentiation between them should be made only by combining clinical, biochemical, imaging and, finally, histology work ups (10,11,15).…”

Section: Fatty Livermentioning

confidence: 99%

“…Ultrasonographically, fat accumulation in the liver is represented by increased parenchymal echogenicity (bright liver) and poor distinction of the blood vessel borders and diaphragm due to decreased acoustic penetration (10). Grading is usually evaluated as mild (grade 1), moderate (grade 2) or severe (grade 3).…”

Section: Fatty Livermentioning

confidence: 99%

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The role of conventional ultrasound in pediatric chronic liver diseases

Kekez¹

2016

Pedaiatr Today

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The aim of this article is to provide an overview of conventional ultrasound in imaging chronic liver diseases in children. The first part describes the normal ultrasound appearance of a child`s liver and the concepts of examination. The further sections present the usual ultrasound findings, the key sonographic points of the most common chronic paediatric liver conditions, and the role of ultrasound in providing diagnostic and prognostic information, detecting complications and supporting reassuring liver biopsy. The limitations of the method are also discussed. Taking all this into account, the interpretation of ultrasound is better in the context of the clinical picture and, in inconclusive cases, followed up with additional imaging and laboratory work up. Conclusion -In conclusion, regardless of the progress made in diagnostic methodology, ultrasound still remains the first, but mostly not the last imaging modality for presumed chronic liver diseases, in daily clinical practice.

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Section: Fatty Livermentioning

confidence: 99%

Section: Fatty Livermentioning

confidence: 99%

Section: Fatty Livermentioning

confidence: 99%

Section: Fatty Livermentioning

confidence: 99%

See 2 more Smart Citations

The role of conventional ultrasound in pediatric chronic liver diseases

Kekez¹

2016

Pedaiatr Today

View full text Add to dashboard Cite

show abstract

“…In a recent issue of Pediatrics Today, Fitzpatrick and Hadzic provide a concise and comprehensive overview on actual knowledge on NAFLD in pediatric setting (1). In the recent years many advances have been made in the pathogenesis/risk factors and therapeutic approach in children with NAFLD/NASH.…”

mentioning

confidence: 99%