Liver Transplantation for Acetaminophen-Induced Acute Liver Failure: Role of Psychiatric Comorbidity in Listing Decisions and Outcomes

Simmons, Okeefe L.; Meinzer, Caitlyn; Rule, Jody; Lee, William M.

doi:10.1007/s10620-019-05901-2

Cited by 6 publications

(2 citation statements)

References 15 publications

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“…Acetaminophen (APAP) has proved to be the main cause of ALF [ 21 ]. The following people are highly likely to experience ALF stimulated by APAP: alcoholic people who use APAP; people who suffer from malnutrition; or people who take medications that are believed to induce CYP450 enzymes (e.g., phenytoin, carbamazepine, or rifampin).…”

Section: Pathophysiology Of Alfmentioning

confidence: 99%

Mesenchymal stromal cells (MSCs) and their exosome in acute liver failure (ALF): a comprehensive review

et al. 2022

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Recently, mesenchymal stromal cells (MSCs) and their derivative exosome have become a promising approach in the context of liver diseases therapy, in particular, acute liver failure (ALF). In addition to their differentiation into hepatocytes in vivo, which is partially involved in liver regeneration, MSCs support liver regeneration as a result of their appreciated competencies, such as antiapoptotic, immunomodulatory, antifibrotic, and also antioxidant attributes. Further, MSCs-secreted molecules inspire hepatocyte proliferation in vivo, facilitating damaged tissue recovery in ALF. Given these properties, various MSCs-based approaches have evolved and resulted in encouraging outcomes in ALF animal models and also displayed safety and also modest efficacy in human studies, providing a new avenue for ALF therapy. Irrespective of MSCs-derived exosome, MSCs-based strategies in ALF include administration of native MSCs, genetically modified MSCs, pretreated MSCs, MSCs delivery using biomaterials, and also MSCs in combination with and other therapeutic molecules or modalities. Herein, we will deliver an overview regarding the therapeutic effects of the MSCs and their exosomes in ALF. As well, we will discuss recent progress in preclinical and clinical studies and current challenges in MSCs-based therapies in ALF, with a special focus on in vivo reports.

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Section: Pathophysiology Of Alfmentioning

confidence: 99%

Mesenchymal stromal cells (MSCs) and their exosome in acute liver failure (ALF): a comprehensive review

et al. 2022

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“…This drug has been used as an analgesic agent after liver resection (LR). However, cases of severe liver dysfunction have been reported in association with the administration of acetaminophen, occasionally necessitating liver transplantation 4,5 . There have been no reports on the safety, toxicity, or drug pharmacology of acetaminophen following different types of LR with various degrees of fibrosis in Japanese patients.…”

Section: Introductionmentioning

confidence: 99%

The feasibility and safety in using acetaminophen with fentanyl for pain control after liver resection with regards to liver function: A prospective single‐center pilot study in Japan

Hidaka

Ohyama

Hara

et al. 2021

J Hepato Biliary Pancreat

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Introduction Acetaminophen has been widely used as an analgesic agent after various types of surgery. However, acetaminophen may sometimes induce severe liver dysfunction, which can occasionally lead to the need for liver transplantation. The aim of this study was to assess the feasibility and efficacy of administering acetaminophen to patients after liver resection (LR). Patients and methods The prospective study included 50 patients who underwent the following procedures: partial LR (n = 21) and more than one section LR (n = 29). Pain control was provided with continuous intravenous fentanyl and acetaminophen every 6 hours (within 2 days). We analyzed the liver function and blood concentration of acetaminophen at 1 and 3 days after LR using high performance liquid chromatography (HPLC), and investigated the results of partial and more than one section LR, and also examined the degree of liver fibrosis. Results The alanine transaminase level on postoperative days 1, 5, and 7 and total bilirubin on postoperative days 1 to 5 after LR in patients with more than one section LR was significantly higher than the levels in patients with partial resection. No patients developed liver failure. The blood concentration of acetaminophen by HPLC was significantly elevated in patients with resection of more than one section in comparison to the partial resection group. Conclusion The safety of acetaminophen was evaluated in Japanese patients who underwent different types of LR with different degrees of liver fibrosis.

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The Suicidal Patient in Organ Transplantation

Posada

Crone²

2022

Transplant Psychiatry

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Liver Transplantation for Acetaminophen-Induced Acute Liver Failure: Role of Psychiatric Comorbidity in Listing Decisions and Outcomes

Cited by 6 publications

References 15 publications

Mesenchymal stromal cells (MSCs) and their exosome in acute liver failure (ALF): a comprehensive review

Mesenchymal stromal cells (MSCs) and their exosome in acute liver failure (ALF): a comprehensive review

The feasibility and safety in using acetaminophen with fentanyl for pain control after liver resection with regards to liver function: A prospective single‐center pilot study in Japan

The Suicidal Patient in Organ Transplantation

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