Liver Transplantation Biomarkers in the Metabolomics Era

Current Status of Biomarkers and Molecular Diagnostic Tools for Rejection in Liver Transplantation: Light at the End of the Tunnel?

“…Metabolic biomarkers depend on detecting multiple metabolic products or intermediary products to assess pathophysiologic processes during liver rejection. 45 One of the earliest reports described the use of Hi-nuclear magnetic resonance to evaluate the metabolic profile of grafted liver before and after LT. 37 Another report described the different metabolic patterns associated with graft dysfunction and development of rejection after transplantation. 38 Despite their promising prospective, no metabolic profiling technique has yet been transferred to clinical practice.…”

Metabonomic Profile of Macrosteatotic Allografts for Orthotopic Liver Transplantation in Patients With Initial Poor Function: Mechanistic Investigation and Prognostic Prediction

“…Metabolomics data provides systematic knowledge of metabolome which might be helpful for early detection of allograft quality and prediction of prognosis after liver transplantation. And these metabolomics data can be integrated to be explained for the mechanism of inferior survival caused by clinical risk covariates, and provide potent interventions for improvement of the allograft quality ( Bonneau et al, 2016 ; Cortes et al, 2017 ). Online toolkit (like MetaboAnalyst) provides concise but meaningful interpretations for the metabonomic data via pathway and enrichment analysis ( Xia et al, 2015 ).…”