Current Status of Biomarkers and Molecular Diagnostic Tools for Rejection in Liver Transplantation: Light at the End of the Tunnel?

Sabagh, Ahmed El; Mohamed, Islam B.; Aloor, Fuad Zain; Afifi, Ahmed; Hassan, Manal M.; Jalal, Prasun K.

doi:10.1016/j.jceh.2022.06.010

Cited by 3 publications

(6 citation statements)

References 73 publications

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“…On the other hand, these molecules could also have an essential function in cold ischemia-reperfusion injury, as previously reported [67,68]. Additionally, since their discovery, research on miRNA expression profiles has shown promise for predicting kidney graft status in a variety of clinical contexts, including acute or delayed graft function, rejection, liver and heart transplant, hematological transplantation, or bone fragility in chronic kidney disease [6,26,[69][70][71][72][73][74][75].…”

Section: Microrna Molecules and Their Role In Transplantationmentioning

confidence: 80%

“…On the other hand, the group of Coutance et al [73] also designed a prospective study (NCT02672683) including recipients from 11 centers between 08/2016 and 03/2018 [71]. The objective was to validate the association between three previously identified circulating microRNAs (10a, 92a, 155) and rejection.…”

Section: Microrna Molecules and Their Role In Transplantationmentioning

confidence: 99%

“…In this way, miR-150 plays a crucial role in immune regulatory processes such as B and T lymphocyte proliferation, activation, and apoptosis. It is also explicitly expressed in lymph nodes, the spleen, and mature B and T cells [71,76]. One of the most researched miRNAs, it is involved in innate and adaptive immune responses and is crucial for the pathogenesis of various malignancies [75,76].…”

Section: Microrna Molecules and Their Role In Transplantationmentioning

confidence: 99%

“…Numerous B lymphocyte subpopulations, including germline naive B lymphocytes, have had their expression of miRNAs examined, demonstrating that these molecules may be crucial for effector activities and regulatory networks governing cell growth [63,71]. In this manner, different miRNAs have been implicated in B cell function and antibody production.…”

Section: Microrna Molecules In B Cell Humoral Rejection and Dsa Produ...mentioning

confidence: 99%

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MicroRNAs as Potential Graft Rejection or Tolerance Biomarkers and Their Dilemma in Clinical Routines Behaving like Devilish, Angelic, or Frightening Elements

Legaz,

Jimenez-Coll,

González-López

et al. 2024

Biomedicines

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Allograft rejection is a widespread complication in allograft recipients with chronic kidney disease. Undertreatment of subclinical and clinical rejection and later post-transplant problems are caused by an imperfect understanding of the mechanisms at play and a lack of adequate diagnostic tools. Many different biomarkers have been analyzed and proposed to detect and monitor these crucial events in transplant outcomes. In this sense, microRNAs may help diagnose rejection or tolerance and indicate appropriate treatment, especially in patients with chronic allograft rejection. As key epigenetic regulators of physiological homeostasis, microRNAs have therapeutic potential and may indicate allograft tolerance or rejection. However, more evidence and clinical validation are indispensable before microRNAs are ready for clinical prime time.

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Section: Microrna Molecules and Their Role In Transplantationmentioning

confidence: 80%

Section: Microrna Molecules and Their Role In Transplantationmentioning

confidence: 99%

Section: Microrna Molecules and Their Role In Transplantationmentioning

confidence: 99%

Section: Microrna Molecules In B Cell Humoral Rejection and Dsa Produ...mentioning

confidence: 99%

See 2 more Smart Citations

MicroRNAs as Potential Graft Rejection or Tolerance Biomarkers and Their Dilemma in Clinical Routines Behaving like Devilish, Angelic, or Frightening Elements

Legaz,

Jimenez-Coll,

González-López

et al. 2024

Biomedicines

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“…Alternative therapies are beneficial to address the scarcity of donors, surplus demand for LTs, and high risks or after-effects involved. Even though there are recent advances in identifying biomarkers or molecular diagnostic tools for predicting organ rejection after LT, further studies are needed to obtain a conclusive picture [17]. Recent advances in the field of regenerative medicine, stem cells, and tissue engineering can serve as a potential alternative or supplement to the LT process.…”

Section: Liver Transplantation: Significance and Current Statusmentioning

confidence: 99%

Recent Advances in Liver Tissue Engineering as an Alternative and Complementary Approach for Liver Transplantation

Nair,

Weiskirchen

2023

CIMB

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Acute and chronic liver diseases cause significant morbidity and mortality worldwide, affecting millions of people. Liver transplantation is the primary intervention method, replacing a non-functional liver with a functional one. However, the field of liver transplantation faces challenges such as donor shortage, postoperative complications, immune rejection, and ethical problems. Consequently, there is an urgent need for alternative therapies that can complement traditional transplantation or serve as an alternative method. In this review, we explore the potential of liver tissue engineering as a supplementary approach to liver transplantation, offering benefits to patients with severe liver dysfunctions.

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Global research hotspots and trends of acute rejection after liver transplantation from 1988 to 2022: a bibliometric analysis

Xiong,

Yang,

Wang

et al. 2024

Front. Pharmacol.

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Background: Acute rejection (AR) is the predominant form of rejection observed in liver transplantation and plays a crucial role in transplant immunology. This study aims to utilize bibliometric analysis to understand the status quo, hotspots, and future trends of research on AR after liver transplantation.Methods: We searched the Web of Science Core Collection (WoSCC) for studies on AR after liver transplantation published from 1988 to 2022. The Bibliometric Online Analysis Platform, VOSviewer, and CiteSpace were used for analysis of all extracted publications.Results: This study included 2,398 articles published in 456 journals by 12,568 authors from 1,965 institutions in 55 countries/regions. The United States and its affiliated institution, the University of Pittsburgh, were the most productive contributors. Transplantation (n = 12,435) was the most frequently cited journal. Neuhaus P (n = 38) was the highest output author, and Demetris AJ (n = 670) was the most co-cited author. The research hotspots of AR after liver transplantation include pathogenesis, immunosuppressive therapy, and prognosis. Emerging research directions include regulatory T cells, immunosuppression minimization, intra-patient variability (IPV) of tacrolimus, and novel non-invasive diagnostic markers.Conclusion: Our study utilized bibliometric methods to analyze the study of AR after liver transplantation over the past 35 years. With the prolonged survival of liver transplant recipients, the most active areas currently focus on individualized treatment and improving patient prognosis. Minimizing adverse reactions to immunosuppressive therapy while simultaneously avoiding an increase in the risk of AR remains a future research focus.

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Current Status of Biomarkers and Molecular Diagnostic Tools for Rejection in Liver Transplantation: Light at the End of the Tunnel?

Cited by 3 publications

References 73 publications

MicroRNAs as Potential Graft Rejection or Tolerance Biomarkers and Their Dilemma in Clinical Routines Behaving like Devilish, Angelic, or Frightening Elements

MicroRNAs as Potential Graft Rejection or Tolerance Biomarkers and Their Dilemma in Clinical Routines Behaving like Devilish, Angelic, or Frightening Elements

Recent Advances in Liver Tissue Engineering as an Alternative and Complementary Approach for Liver Transplantation

Global research hotspots and trends of acute rejection after liver transplantation from 1988 to 2022: a bibliometric analysis

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