Liver Transplantation-associated Hypercalcemia Followed by Acute Renal Dysfunction

Shirasawa, Yuichi; Nomura, Tomoyuki; Yoshida, Atsuhiro; Hashimoto, Takashi; Kimura, Genjiro; Itô, Makoto

doi:10.2169/internalmedicine.43.802

Cited by 8 publications

(9 citation statements)

References 26 publications

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“…Renal function and size are normal in GSD‐III (43), and there are no reported cases of renal transplantation for this metabolic disease. Hypercalcemia‐induced acute renal failure was reported in a 34‐yr‐old female after OLT for GSD‐III‐associated cirrhosis, however, the pathogenesis was not determined (40). Intravenous pamidronate successfully suppressed the hypercalcemia in this patient and adequate renal function was reestablished.…”

Section: Renal or Combined Renal/liver Transplantation In Gsd‐iiimentioning

confidence: 99%

“…Liver transplantation has rarely been performed in GSD‐III for indications including cirrhotic liver disease and risk of hepatic malignancy. Five cases of OLT performed in GSD‐III patients have been reported and only one of these cases involved a child (26, 38–41). A three‐yr‐old female underwent OLT for cirrhosis and liver dysfunction and was reported alive and well two yr after the transplantation (Table 3).…”

Section: Liver Transplantation In Gsd‐iiimentioning

confidence: 99%

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Liver transplantation in children with glycogen storage disease: Controversies and evaluation of the risk/benefit of this procedure

Davis

Weinstein

2007

Pediatric Transplantation

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GSD-I, III, and IV are congenital disorders of glycogen metabolism that are commonly associated with severe liver disease. Liver transplantation has been proposed as a therapy for these disorders. While liver transplantation corrects the primary hepatic enzyme defect, the extrahepatic manifestations of GSD often complicate post-transplantation management. Upon review of the English-language literature, 42 children <19 yr of age were discovered to have undergone liver transplantation for complications associated with GSD (18 patients with GSD-Ia, six with GSD-Ib, one with GSD-III, 17 with GSD-IV). An additional two children followed at our institution have undergone liver transplantation for GSD complications (one with GSD-Ia and one with GSD-III) and are included in this review. The risks and benefits of liver transplantation should be considered prior to performing liver transplantation in these metabolic disorders, particularly in GSD-Ia. As liver pathology is not the major source of morbidity in GSD-Ib and GSD-IIIa, liver transplantation should only be performed when there is high risk for HCC or evidence of substantial cirrhosis or liver dysfunction. Liver transplantation remains the best option for treatment of GSD-IV.

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Section: Renal or Combined Renal/liver Transplantation In Gsd‐iiimentioning

confidence: 99%

Section: Liver Transplantation In Gsd‐iiimentioning

confidence: 99%

Liver transplantation in children with glycogen storage disease: Controversies and evaluation of the risk/benefit of this procedure

Davis

Weinstein

2007

Pediatric Transplantation

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“…In the United States, more than 80% of patients with GSDIII have both liver and muscle involvement (78). Renal function is often normal, but cases of acute renal failure (79) are reported even if the pathogenesis is not clear. Full guidelines on the GSDI diagnosis and management have been published by the American (80).…”

Section: Glycogen Storage Diseasementioning

confidence: 99%

Liver Transplantation for Monogenic Metabolic Diseases Involving the Kidney

Salvadori

Tsalouchos

2017

jrenhep

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Several metabolic monogenic diseases may be cured by liver transplantation alone (LTA) or by combined liver–kidney transplantation (CLKT) when the metabolic disease has caused end-stage renal disease. Liver transplantation may be regarded as a substitute for an injured liver or as supplying a tissue that may replace a mutant protein. Two groups of diseases should be distinguished. In the first group, the kidney tissue may be severely damaged while the liver tissue is almost normal. In this group, renal transplantation is recommended according to the degree of renal damage and liver transplantation is essential as a genetic therapy for correcting the metabolic disorder. In the second group, the liver parenchymal damage is severe. In this group, liver transplantation is essential to avoid liver failure. LTA may also avoid the progression of the renal disease; otherwise a CLKT is needed. In this review, we describe monogenic metabolic diseases involving the kidney that may have beneficial effects from LTA or CLKT. We also highlight the limitations of such procedures and the choice of alternative medical conservative treatments.

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“…К настоящему мо-менту описаны 6 случаев проведения ортотопиче-ской трансплантации печени, и только в двух слу-чаях пересадка печени проводилась ребенку [20,30,35,45,49]. В первый раз реципиентом являлась де-вочка трех лет, и в течение двух лет наблюдения по-сле трансплантации печени функция трансплантата оставалась удовлетворительной [30].…”

Section: гликогеноз III типаunclassified

“…Острая по-чечная недостаточность на фоне гиперкальциемии была описана у 34-летней пациентки после транс-плантации печени [45]. На фоне внутривенного введения памидроната отмечалась положительная динамика и нормализация функции почек.…”

Section: гликогеноз III типаunclassified

Liver Transplantation in Children With Glycogen Storage Diseases: Risk Assessment and Necessity of This Procedure

Готье¹,

Цирульникова²,

Мнацаканян³

et al. 2014

Russian Journal of Transplantology and Artificial Organs

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1 ФГБУ «Федеральный научный центр трансплантологии и искусственных органов им. академика В.И. Шумакова» Минздрава России, г. Москва 2 ГБОУ ВПО «Первый МГМУ имени И.М. Сеченова», кафедра трансплантологии и искусственных органов, г. Москва Болезни накопления гликогена I, III, IV типа являются врожденными заболеваниями, которые обычно ведут к тяжелому поражению печени. Трансплантация печени является терапией выбора при данных патологиях. В то время как пересадка печени нивелирует первичный дефект фермента в печени, внепе-ченочные проявления гликогенозов порой осложняют посттрансплантационный период. В статье опи-саны данные англоязычной литературы, согласно которой 42 детям до 18 лет по поводу осложнений гликогенозов были проведены трансплантации печени (18 пациентам -в связи с гликогенозом Ia типа, шестерым -Ib, одному ребенку -III типа, 17 пациентам -по поводу гликогеноза IV типа). В работе представлено описание трансплантации печени ребенку по поводу гликогеноза Ia типа, проведен анализ посттрансплантационного периода жизни реципиента. Glycogen storage diseases I, III and IV types are congenital disorders, which are commonly associated with severe liver diseases. Liver transplantation has been proposed as a treatment of choise for these disorders. While liver transplantation corrects the primary hepatic enzyme defect, the extrahepatic manifestations of glycogenoses often complicate the posttransplant management. Upon review of the English-language literature, 42 children under 18 years old were discovered to have undergone liver transplantation for complications associated with glycogenoses (18 patients with Ia type, 6 -with Ib type, one patient -with III type, 17 -with IV type). This article represents the pediatric liver transplantation for complications associated with glycogenosis Ia type, analyzed posttransplant period in this recipient.

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Liver Transplantation-associated Hypercalcemia Followed by Acute Renal Dysfunction

Cited by 8 publications

References 26 publications

Liver transplantation in children with glycogen storage disease: Controversies and evaluation of the risk/benefit of this procedure

Liver transplantation in children with glycogen storage disease: Controversies and evaluation of the risk/benefit of this procedure

Liver Transplantation for Monogenic Metabolic Diseases Involving the Kidney

Liver Transplantation in Children With Glycogen Storage Diseases: Risk Assessment and Necessity of This Procedure

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