Liver Resident Stem Cell

Takiya, Christina Maeda; Paredes, Bruno Diaz; Quintanilha, Luiz Fernando; Dias, Grazielle Suhett; Faccioli, Lanuza Alaby Pinheiro; Takami, Taro; Terai, Shuji; Sakaida, Isao; Goldenberg, Regina Coeli dos Santos

doi:10.1016/b978-0-12-416012-5.00010-4

Cited by 3 publications

(2 citation statements)

References 168 publications

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“…In human beings and rodents, both hepatic progenitor cells and cholangiocytes are known to express CKs 7 and 19. 6,18 Therefore, it was reasonable that cholangiocellular components in the present case were immunoreactive to all CK clones used, and scattered immunoreactivity to AE1/AE3 and MNF116 for oval-shaped cells may be indicative of CK19 expression in hepatic progenitor cells. In contrast, hepatocellular differentiation is characterized by the progressive loss of biliary CKs, showing negativity to CK19 and the weak expression of CK7.…”

Section: Research-article2014mentioning

confidence: 61%

“…12 Epithelial cell adhesion molecule is also a known marker of hepatic progenitor cells in human beings and rodents, 15,18,22 while α-1-fetoprotein is a marker for hepatoblasts, mouse oval cells, and hepatocytes. 4,9,14 In the present case, immunoreactivity to AFP, SALL4, and EpCAM was observed for all types of neoplastic cells, suggesting that these proteins could be markers of hepatobiliary progenitor cells in pigs.…”

Section: Research-article2014mentioning

confidence: 99%

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Immunohistochemical characterization of multicentric hepatocholangiocellular adenoma in a pig

et al. 2014

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Abstract. Three spherical opaque-white tumor nodules were found in close proximity to each other in the liver of a breeding sow, postslaughter, at a veterinary food inspection. The tumor nodules were circumscribed and histologically consisted of discrete hepatocellular and cholangiocellular nests, in association with polygonal-to-oval-shaped cells with slight cellular atypia. Immunohistochemically, all cellular components were negative for carcinoembryonic antigen, but positive for p53. Both cholangiocytes and oval-shaped cells were immunoreactive to anti-cytokeratin antibodies AE1/AE3 and MNF116. In addition, cholangiocytes were exclusively immunoreactive to anti-cytokeratin antibody CAM5.2, and hepatocytes were positive for MNF116 and hepatocyte paraffin 1. All neoplastic cells were positive for the hepatic progenitor cell markers, α-1-fetoprotein, sal-like protein 4, and epithelial cell adhesion molecule. From these results, the present case was diagnosed as hepatocholangiocellular adenoma, arising from epithelial cells of the canals of Hering.

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Section: Research-article2014mentioning

confidence: 61%

Section: Research-article2014mentioning

confidence: 99%

Immunohistochemical characterization of multicentric hepatocholangiocellular adenoma in a pig

et al. 2014

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Cell Therapy in Chronic Liver Disease

Alhomrani

Lim

Sievert

2016

Stem Cells in Clinical Applications

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Molecular and Morphological Changes Induced by Ivosidenib Correlate with Efficacy in Mutant- IDH1 Cholangiocarcinoma

et al. 2021

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Background: IDH1 mutations occur in approximately 13% of intrahepatic cholangiocarcinomas (IHCCs). The oral, targeted, mutant IDH1 (mIDH1) inhibitor ivosidenib (AG-120) suppresses production of the oncometabolite D-2-hydroxyglutarate, promoting disease stabilization and improved progression-free survival (PFS) in m IDH1 IHCC. Materials & methods: Harnessing matched baseline and on-treatment biopsies, we investigate the potential mechanisms underlying ivosidenib's efficacy. Results: mIDH1 inhibition leads to decreased cytoplasm and expression of hepatocyte lineage markers in patients with prolonged PFS. These findings are accompanied by downregulation of biliary fate, cell cycle progression and AKT pathway activity. Conclusion: Ivosidenib stimulates a hepatocyte differentiation program in m IDH1 IHCC, a phenotype associated with clinical benefit. mIDH1 inhibition could be a paradigm for differentiation-based therapy in solid tumors. Clinical trial registration: NCT02073994 ( ClinicalTrials.gov )

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Liver Resident Stem Cell

Cited by 3 publications

References 168 publications

Immunohistochemical characterization of multicentric hepatocholangiocellular adenoma in a pig

Immunohistochemical characterization of multicentric hepatocholangiocellular adenoma in a pig

Cell Therapy in Chronic Liver Disease

Molecular and Morphological Changes Induced by Ivosidenib Correlate with Efficacy in Mutant- IDH1 Cholangiocarcinoma

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