Liver resection for intrahepatic stones in congenital bile duct dilatation

Clemente, Gennaro; Giuliante, Felice; Rose, Agostino Maria De; Ardito, Francesco; Giovannini, Ivo; Nuzzo, Gennaro

doi:10.1016/j.jviscsurg.2010.06.005

Cited by 14 publications

(9 citation statements)

References 16 publications

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“…Of these, the proliferation process of pancreatic tumors has been studied most precisely using 3D images obtained with a confocal microscopy and morphometric analysis . On the other hand, there are few studies involving 3D analysis of the morphogenesis and morphometrics of biliary diseases, including cholangiocarcinoma, primary sclerosing cholangitis, primary biliary cirrhosis, intrahepatic calculosis, and intrahepatic cholestasis of pregnancy . Thus, 3D structural analyses of biliary diseases that include clinical specimens comprise one of the most important subjects in future studies.…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, for clinical medicine and treatment of liver disease patients, in addition to direct observations of diseased tissues by endoscopic retrograde cholangiopancreatography, computed tomography (CT) and magnetic resonance imaging (MRI) are used as artificial 3D reconstruction techniques for indirect observations. A digitally reconstructed 3D model is used for anatomical findings and diagnosis and also for liver transplantation and resection in various liver diseases . However, because CT and MRI have low resolution (0.5‐2.0 mm), they are difficult to use for pathological diagnosis at the cell and tissue levels for lesion cells and microluminal structures.…”

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confidence: 99%

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Dynamic three‐dimensional morphogenesis of intrahepatic bile ducts in mouse liver development

et al. 2015

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During liver development, biliary epithelial cells differentiated from bipotential hepatic progenitor cells (hepatoblasts) form a cell layer, called the ductal plate surrounding portal veins (PVs), and develop into intrahepatic bile ducts (IBDs) following developmental programs. Because IBDs make duct structures in the liver, it is necessary to perform sequential and three-dimensional (3D) analyses from the early stages of liver development to address the process of morphogenesis in detail. However, to date, the development of IBDs has mainly been investigated using tissue sections in two-dimensional planes, and examinations of the 3D morphogenesis and quantitative analyses based on morphometrics have not been performed. Therefore, in this study, we simulated the solid structures of IBDs from mouse embryos to adults in silico, analyzed the subjects for the length and number of developing duct structures, number of predicted connections, and discrete distance from the PV, and examined the developmental process of the IBD in detail in a quantitative manner. Conclusions: Through quantitative analyses with spatiotemporal observations using a 3D structural reconstruction model and morphometrics, we succeeded in constructing a 3D dynamic model of bile duct formation. Because the 3D reconstruction technique used in this study is available for analyzing solid structures in tissues that are difficult to approach, it shows promise for wide use in the fields of biology and medicine. (HEPATOLOGY 2015;61:1003-1011

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Dynamic three‐dimensional morphogenesis of intrahepatic bile ducts in mouse liver development

et al. 2015

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“…In patients with concurrent or suspected intrahepatic bile duct cancer, hepatectomy is performed if the risks are acceptable. Intrahepatic bile duct cancer is a common complication of hepatolithiasis, with an incidence rate of 5.3-12.9% [196], and is the most important clinical prognosis predictor [197]. However, because preoperative diagnosis is not possible in many cases, and there are many advanced cases, concurrent bile duct cancer should always be considered when patients with hepatolithiasis are being treated.…”

Section: Commentarymentioning

confidence: 99%

“…Most patients in whom hepatectomy is indicated have biliary strictures and dilatation. As residual biliary stricture and dilatation are risk factors for recurrent stone formation and bile duct cancer, resection must encompass these structures [190][191][192][193][194][195][196][197][198][199][200][201][202][203][204]. Therefore, extrahepatic bile duct resection with biliary reconstruction is needed in patients with concurrent cancer of the portal area and extrahepatic bile duct, with concurrent pancreatic-bile duct junction abnormalities, and with strictures extending from the portal area to the extrahepatic bile duct.…”

Section: Commentarymentioning

confidence: 99%

Evidence-based clinical practice guidelines for cholelithiasis 2016

Tazuma

Unno²,

Igarashi³

et al. 2016

J Gastroenterol

209

178

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Cholelithiasis is one of the commonest diseases in gastroenterology. Remarkable improvements in therapeutic modalities for cholelithiasis and its complications are evident. The Japanese Society of Gastroenterology has revised the evidence-based clinical practice guidelines for cholelithiasis. Forty-three clinical questions, for four categories-epidemiology and pathogenesis, diagnosis, treatments, and prognosis and complications-were selected, and a literature search was performed for the clinical questions with use of the MEDLINE, Cochrane, and Igaku Chuo Zasshi databases for the period between 1983 and June 2012. The guidelines were developed with use of the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system. This article preferentially describes the clinical management of cholelithiasis and its complications. Following description of the diagnosis performed stepwise through imaging modalities, treatments of cholecystolithiasis, choledocholithiasis, and hepatolithiasis are introduced along with a flowchart. Since there have been remarkable improvements in endoscopic treatments and surgical techniques, the guidelines ensure flexibility in choices according to the actual clinical environment. The revised clinical practice guidelines are appropriate for use by clinicians in their daily practice.

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“…La alta frecuencia de estenosis postinflamatorias como consecuencia de episodios de colangitis aguda recurrente y la estasia biliar en pacientes con dilataciones quísticas congénitas de la vía biliar intrahepática, explica la frecuente asociación con hepatolitiasis, pero se debe tener en cuenta, que ambas condiciones, hepatolitiasis y dilataciones quísticas congénitas de la vía biliar intrahepática son entidades clínicas diferentes; rara vez la dilatación de la vía biliar intrahepática secundaria a estenosis postinflamatoria, será la manifestación de una enfermedad congénita no diagnosticada con anterioridad como la Enfermedad o el Síndrome de Caroli. La prevalencia de hepatolitiasis en pacientes con Enfermedad o el Síndrome de Caroli fluctúa entre un 55% y un 80% de los pacientes intervenidos quirúrgicamente [6][7][8] .…”

Section: Introductionunclassified

Definiciones y conceptos en hepatolitiasis

C²,

et al. 2013

Rev Chil Cir

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An update on hepatolithiasis Hepatolithiasis or intrahepatic lithiasis is defined as the presence of stones in the biliary ducts proximal to the biliary confluence. The pathogenesis can be primary or secondary, according to the anatomical site were stones are formed. The physiopathologies of primary and secondary hepatolithiasis differ. We have recently reported the results of hepatectomy for the treatment of hepatolithiasis. We have found a significant association between the history of cholecystectomy and the presence of stones in the posterior segments of the right liver lobe. We have also observed a weak association between hepatolithiasis and congenital cystic diseases of the intrahepatic bile ducts (Caroli disease). We herein review concepts and definitions of hepatolithiasis.

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Liver resection for intrahepatic stones in congenital bile duct dilatation

Cited by 14 publications

References 16 publications

Dynamic three‐dimensional morphogenesis of intrahepatic bile ducts in mouse liver development

Dynamic three‐dimensional morphogenesis of intrahepatic bile ducts in mouse liver development

Evidence-based clinical practice guidelines for cholelithiasis 2016

Definiciones y conceptos en hepatolitiasis

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