Liver-protecting effects of omega-3 fish oil lipid emulsion in liver transplantation

Abstract

Post-transplant parenteral nutritional support combined with omega-3 fatty acids can significantly improve the liver injury, reduce the infectious morbidities, and shorten the post-transplant hospital stay.

Effect of Immunosuppressive Therapy on the Serum Fatty Acids of Phospholipids Fraction in Patients After Heart Transplantation

“…It may also decrease the incidence of rejection, but the mechanisms involved remain unknown [27,28]. Supplementation of omega-3 FA may also reduce occurrence of new-onset diabetes mellitus [29], reduce infectious morbidities, and shorten post-transplantation hospital stays [21,30].…”

“…Omega-3 fatty acids, such as EPA and DHA, reduce the release of AA-derived proinflammatory eicosanoids and generate a group of lipid mediators called resolvins and protectins with potent antiinflammatory and inflammation resolution properties [7,8,21]. Lipoxin A4 is generated during host responses to transplant rejection, and together with resolvin, prostaglandin E1 can decrease innate immune responses that give rise to allograft rejection [22].…”

Liver regeneration

“…Zhu and colleagues demonstrated improved serologic studies , decreased post-transplant hospital stay, and reduced infection related morbidity in patients receiving omega-3 fatty acid supplementation compared to patients receiving parenteral nutrition alone 100 . Further evidence supporting the protective effect of fatty acid supplementation following partial hepatectomy is provided by Yan et.al 101 .…”

Protective Effects of Omega Supplement on Induced Hepatic Mal-Function by Thioacetamide in Male Rats

“…Also, Siegel on cerebral-cardiovascular diseases [8]. Likewise, fish oil omega-3 emulsion significantly reduces hepatic damage following liver transplantation [9], and has protective effects against liver fibrosis and injuries as well as oxidative stress induced by carbon tetrachloride [10]. Administration of omega-3 fatty acids may reduce infection rate and improve liver function recovery in HBV-associated hepatocellular carcinoma patient after hepatoctomy.…”