Effect of Immunosuppressive Therapy on the Serum Fatty Acids of Phospholipids Fraction in Patients After Heart Transplantation

Wilusz, M.; Wasilewski, Grzegorz; Przybyłowski, Piotr; Janik, L.; Bugajska, Jolanta; Sztefko, Krystyna

doi:10.1016/j.transproceed.2014.09.043

Cited by 2 publications

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References 31 publications

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“…Some nutritionists suggest consumption of products which are rich with ω-3 and ω-6 fatty acids in order to avoid issues with the health (the terms ω-3 and ω-6 mean polyunsaturated fatty acids which have the first double bond CC at the third or sixth carbon atom from the end of the chain, respectively). It was also discovered that PUFAs are useful for the treatment of mental diseases and memory problems, − heart diseases and problems with a high blood pressure, − atherosclerosis, dyslipidemia, inflammation, cancer, − Parkinson, problems with the vision, diabetes, and fatty liver disease. , The significant positive effects of the consumption of PUFAs were discovered on children’s performance inlearning . At the same time some harmful effects of the consumption of PUFAs were discovered: pro-hemorrhagic effect, negative effects on immune functions, formation of oxidative products by ω-3 polyunsaturated fatty acids .…”

Section: Introductionmentioning

confidence: 99%

Extension of the Slipids Force Field to Polyunsaturated Lipids

Ermilova

Lyubartsev

2016

J. Phys. Chem. B

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The all-atomic force field Slipids (Stockholm Lipids) for lipid bilayers simulations has been extended to polyunsaturated lipids. Following the strategy adopted in the development of previous versions of the Slipids force field, the parametrization was essentially based on high-level ab initio calculations. Atomic charges and torsion angles related to polyunsaturated lipid tails were parametrized using structures of dienes molecules. The new parameters of the force field were validated in simulations of bilayers composed of seven polyunsaturated lipids. An overall good agreement was found with available experimental data on the areas per lipids, volumetric properties of bilayers, deuterium order parameters, and scattering form factors. Furthermore, simulations of bilayers consisting of highly polyunsaturated lipids and cholesterol molecules have been carried out. The majority of cholesterol molecules were found in a position parallel to bilayer normal with the hydroxyl group directed to the membrane surface, while a small fraction of cholesterol was found in the bilayer center parallel to the membrane plane. Furthermore, a tendency of cholesterol molecules to form chain-like clusters in polyunsaturated bilayers was qualitatively observed.

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