Liver Preservation With Machine Perfusion and a Newly Developed Cell-Free Oxygen Carrier Solution Under Subnormothermic Conditions

Fontes, Paulo; López, Roberto; Plaats, Arjan van der; Vodovotz, Yoram; Minervini, Marta Ida; Scott, Victor L.; Soltys, Kyle; Shiva, Sruti; Paranjpe, Shirish; Sadowsky, David; Barclay, Derek; Zamora, Rubén; Stolz, Donna B.; Demetris, Anthony J.; Michalopoulos, Georgios; Marsh, J. Wallis

doi:10.1111/ajt.12991

Cited by 108 publications

(108 citation statements)

References 49 publications

Supporting

Mentioning

104

Contrasting

Order By: Relevance

“…Biliary complications were significantly lower in the HMP group compared to the CS group [46]. Fontes et al recently reported fully oxygenated perfusion of liver grafts under sub-normothermic perfusion of liver grafts conditions with a new hemoglobin-based oxygen carrier solution [48]. In an animal model, they proved that this perfusion modality was associated with a downregulation of inflammatory products in liver tissue: liver grafts cleared lactate, produced urea, sustained gluconeogenesis, and produced bile with improved graft function.…”

Section: Ex Vivo Machine Perfusion Of Liver Graftsmentioning

confidence: 97%

Liver Transplantation Using Grafts from Donation After Cardiac Death Donors

2015

View full text Add to dashboard Cite

Utilization of liver grafts from donation after cardiac death donors has been proposed as a potential solution to the organ shortage for patients suffering from end-stage liver disease. The number of donation after cardiac death donors is likely to increase as a consequence of changing demographics and improvements in neurologic care. This potential has not been realized to full effect due to reports of inferior outcomes of liver transplantation using these grafts. In order to continue to provide excellent transplant care, it is critical to have an understanding of the factors necessary for successful use of liver grafts from donation after cardiac death donors. In this review, we will appraise the current understanding of the challenges involved in using these grafts, the critical recipient and donor considerations, and future directions.

show abstract

Section: Ex Vivo Machine Perfusion Of Liver Graftsmentioning

confidence: 97%

Liver Transplantation Using Grafts from Donation After Cardiac Death Donors

2015

View full text Add to dashboard Cite

show abstract

“…Typically, perfusates based on concentrates of red blood cells, plasma, nutrients, cofactors and insulin, antibiotics, electrolytes and buffers are required, which makes normothermic machine perfusion a complex and expensive procedure [124]. To avoid the use of human blood products, the interest in extracellular oxygen carriers or oxygen-carrying plasma expanders has increased [131]. …”

Section: Classification Of Perfusion Techniques Based On Preservationmentioning

confidence: 99%

Organ Preservation into the 2020s: The Era of Dynamic Intervention

Petrenko

Carnevale

Somov

et al. 2019

Transfus Med Hemother

View full text Add to dashboard Cite

Organ preservation has been of major importance ever since transplantation developed into a global clinical activity. The relatively simple procedures were developed on a basic comprehension of low-temperature biology as related to organs outside the body. In the past decade, there has been a significant increase in knowledge of the sequelae of effects in preserved organs, and how dynamic intervention by perfusion can be used to mitigate injury and improve the quality of the donated organs. The present review focuses on (1) new information about the cell and molecular events impacting on ischemia/reperfusion injury during organ preservation, (2) strategies which use varied compositions and additives in organ preservation solutions to deal with these, (3) clear definitions of the developing protocols for dynamic organ perfusion preservation, (4) information on how the choice of perfusion solutions can impact on desired attributes of dynamic organ perfusion, and (5) summary and future horizons.

show abstract

“…34 However, as a result of ischemia during OLT, a sterile immune response is initiated, with elevated levels of proinflammatory cytokines (eg, interferon-γ and interleukins) and infiltration of inflammatory cells into the biliary epithelium, which can result in an upregulation of HLA class II antigens. 21,35,36 Ischemiareperfusion injury (IRI) of the biliary epithelium is also considered as one of the most important risk factors for NAS development. The effect of IRI is not limited to cholangiocytes only.…”

Section: T a B L E 4 Univariate And Multivariate Analyses Of Risk Facmentioning

confidence: 99%

Donor-specific anti-HLA antibodies are not associated with non-anastomotic biliary strictures, but both are independent risk factors for graft loss after liver transplantation

Dulk¹,

Shi²,

Verhoeven³

et al. 2018

Journal of Hepatology

View full text Add to dashboard Cite

Donor-specific alloantibodies (DSA) have been associated with rejection and shorter graft survival after orthotopic liver transplantation (OLT). We examined the role of DSA in nonanastomotic biliary strictures (NAS) after OLT. Patients receiving first OLT who developed NAS (n = 68) and a control group without NAS (n = 83), with pre-OLT and 12 months post-OLT serum samples, were included. DSA were specified using the Luminex single antigen test. Risk factors for NAS and graft survival were analyzed. The presence of preformed DSA was not significantly different between patients with NAS and controls (P = .89). After 12 months, 26.5% of NAS patients and 16.9% of controls had generated de novo DSA (P = .15). Neither de novo class I DSA nor de novo class II DSA were associated with NAS. De novo DSA generally developed after the diagnosis of NAS. Time-dependent regression analysis identified both NAS (aHR 8.05, CI 3.28 -19.77, P < .01) and de novo class II DSA (aHR 2.84, CI 1.38 -5.82, P < .01) as independent risk factors for graft loss. Preformed or de novo DSA were not associated with the development of NAS. However, NAS as well as de novo class II DSA were independent risk factors for graft loss after OLT. K E Y W O R D Sbiliary strictures, complications, donor-specific antibodies, HLA-antibody post-transplantation, liver transplantation, outcomeThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

show abstract

Liver Preservation With Machine Perfusion and a Newly Developed Cell-Free Oxygen Carrier Solution Under Subnormothermic Conditions

Cited by 108 publications

References 49 publications

Liver Transplantation Using Grafts from Donation After Cardiac Death Donors

Liver Transplantation Using Grafts from Donation After Cardiac Death Donors

Organ Preservation into the 2020s: The Era of Dynamic Intervention

Donor-specific anti-HLA antibodies are not associated with non-anastomotic biliary strictures, but both are independent risk factors for graft loss after liver transplantation

Contact Info

Product

Resources

About